Clinical Chemistry and Laboratory Medicine

Does patient-based data monitoring allow us to reconsider the relationship between IQC and EQA?Tony Badrickon September 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 24. doi: 10.1515/cclm-2025-1133. Online ahead of print. ABSTRACT Currently, there is no accepted standard practice for determining the frequency of EQA challenge. The challenge frequency has evolved based on history and local requirements. However, EQA frequency should be based on identifying patient risks caused by poorly performing laboratories, methods, … Read more

Comparative analysis of ISO 15189:2022 with earlier versions with reference to ethicsSudip K Dattaon September 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 24. doi: 10.1515/cclm-2025-0884. Online ahead of print. ABSTRACT OBJECTIVES: The International Organisation for Standardisation (ISO) 15189 standard provides the requirements for quality and competence in medical laboratories. It aims to ensure that laboratories deliver accurate and reliable results for patient care. The first version of the same was published … Read more

EQALM recommendations for the analytical performance specifications for blood smear interpretation in haematology: a need for standardizationStéphanie Albarèdeon September 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 24. doi: 10.1515/cclm-2025-1011. Online ahead of print. ABSTRACT OBJECTIVES: The European Organization for External Quality Assurance Providers in Laboratory Medicine (EQALM) Haematology Working Group (WG) has previously provided two guidelines to support the standardization of haematology blood smear external quality assessment (EQA) (Vives CJL, Albarède S, Flandrin G, Heller … Read more

Influence of remnant cholesterol on direct LDL and HDL cholesterol measurement accuracySoon Sung Kwonon September 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 22. doi: 10.1515/cclm-2025-0593. Online ahead of print. ABSTRACT OBJECTIVES: Identifying the potential sources of bias in the direct measurement of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) is important. In this study, we aimed to investigate the effect of remnant cholesterol on LDL-C and HDL-C levels measured … Read more

Comparative analysis of monocyte distribution width alterations in Escherichia coli sepsis: insights from in vivo and ex vivo modelsDaniela Ligion September 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 18. doi: 10.1515/cclm-2025-0487. Online ahead of print. ABSTRACT OBJECTIVES: Monocyte distribution width (MDW) is an early sepsis indicator measuring monocyte heterogeneity during massive infection. We compared MDW changes in Escherichia coli sepsis patients with the effects of living E. coli and lipopolysaccharide in an ex vivo sepsis model. We … Read more

CA-125 glycovariant assays enhance diagnostic sensitivity in the detection of epithelial ovarian cancerStefanos Moukason September 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 18. doi: 10.1515/cclm-2025-0561. Online ahead of print. ABSTRACT OBJECTIVES: Ovarian cancer is the deadliest gynaecologic malignancy. Due to the lack of reliable biomarkers for the detection of the early disease, most patients are diagnosed at an advanced stage resulting in poor survival. We therefore aimed at establishing novel CA-125 … Read more

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