Clinical Chemistry and Laboratory Medicine

ADORE: the performance characteristics of five automated platforms in the analysis of urinary dysmorphic erythrocytes and pathological castsJolien J Luimstraon October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0938. Online ahead of print. ABSTRACT OBJECTIVES: Automated urine particle analyzers are increasingly employed in clinical laboratories to standardize urinalysis. These systems can reduce workload, turnaround time and the inter-observer variation. This study aimed to assess the performance of five automated urine particle analyzers in detecting and … Read more

Automated reticulocyte counting: advances, standardization challenges, and clinical accessibilityHongyin Zhouon October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1032. Online ahead of print. ABSTRACT With the advent of flow cytometry and dedicated fluorescent dyes in the 1980s, automated reticulocyte enumeration has effectively superseded conventional manual microscopy, dramatically boosting throughput and precision while, through metrics including the immature reticulocyte fraction (IRF) and reticulocyte production index (RPI), … Read more

The role of AI in pre-analytical phase – use casesHikmet Can Çubukçuon October 15, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 16. doi: 10.1515/cclm-2025-1220. Online ahead of print. ABSTRACT The pre-analytical phase of laboratory testing, encompassing processes from test ordering to sample analysis, represents the most error-prone component of laboratory medicine, accounting for 68-98 % of laboratory mistakes. These errors compromise patient safety, increase healthcare costs, and disrupt operational efficiency. … Read more

Towards a global framework of entrustable professional activities for undergraduate clinical laboratory interns: a competency-based approachXiaohui Zhangon October 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 14. doi: 10.1515/cclm-2025-1178. Online ahead of print. ABSTRACT OBJECTIVES: The aim of this study is to develop a core competency-based EPAs framework for undergraduate interns in the clinical laboratory. METHODS: The EPAs framework was developed in three stages: formation of a research team, drafting of an initial EPAs framework, … Read more

Performance of GFAP and UCH-L1 compared to S100B in detecting intracranial injury: influence of age, hemolysis, neurodegenerative diseases, and extracranial fractures in a prospective cohort of over 1,000 patientsAntoine Puraveton October 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 9. doi: 10.1515/cclm-2025-1129. Online ahead of print. ABSTRACT OBJECTIVES: To compare the diagnostic performances of GFAP and UCH-L1 with S100B in detecting intracranial injury, while investigating the impact of confounding factors. METHODS: In a large prospective cohort of 1,010 patients with mild traumatic brain injury, we first evaluated the … Read more

Towards harmonization of autoantibody detection in relation to paraneoplastic neurological syndromes (PNS): a European Survey on laboratory practicesMatthijs Oyaerton October 6, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 7. doi: 10.1515/cclm-2025-1030. Online ahead of print. ABSTRACT OBJECTIVES: Detection of paraneoplastic anti-neuronal antibodies (PNS autoantibodies) aids in diagnosing the particular syndrome and guides the search for an underlying tumor. To identify opportunities for harmonization that could enhance diagnostic value, we assessed variability in autoimmune serological testing for PNS … Read more

Estimated waste generation from 1 million basic metabolic panels: a multisite U.S. studySeema Khattri Bhandarion October 6, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 7. doi: 10.1515/cclm-2025-1162. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratory operations consume large amounts of electricity and water and generate considerable quantities of solid waste. In this study, we quantified and compared the estimated solid waste produced from performing one million basic metabolic panels (BMPs) across five major … Read more

Serum neuron-specific enolase – reference interval in Danish children and the impact of preanalytical factorsJacob Rudjord Therkildsenon October 2, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 3. doi: 10.1515/cclm-2025-0582. Online ahead of print. ABSTRACT OBJECTIVES: Neuron-specific enolase (NSE) is a clinically relevant biomarker used in the assessment of neuronal damage and in the diagnosis and monitoring of certain cancers. Despite its diagnostic importance, paediatric-specific reference intervals (RIs) for NSE are currently lacking. This study aimed … Read more

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