Clinical Chemistry and Laboratory Medicine

Methodological evaluation and clinical interpretation of hs-cTnI and hs-cTnT variations: a reappraisalAldo Clericoon October 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 28. doi: 10.1515/cclm-2025-1318. Online ahead of print. ABSTRACT Recent debates have focused on the impact of analytical imprecision in high-sensitivity cardiac troponin (hs-cTnI and hs-cTnT) assays on the diagnosis of non-ST-elevation myocardial infarction (NSTEMI), based on the absolute delta thresholds for the rapid rule-in/rule-out algorithms in emergency department (ED) … Read more

Hemolysis index. Can we uncritically trust manufacturer declarations?Alen Vrtaricon October 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-1302. Online ahead of print. ABSTRACT OBJECTIVES: Hemolysis is a common preanalytical interference in clinical biochemistry, affecting up to 3.3 % of routine samples and contributing to approximately 60 % of rejected specimens. It results from the release of intracellular constituents, such as hemoglobin and potassium, into … Read more

ReferenceRangeR: a novel tool designed to facilitate reference interval estimation and verificationGunnar Brandhorston October 22, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-0637. Online ahead of print. ABSTRACT OBJECTIVES: Reference intervals (RIs) are essential for interpreting laboratory test results. It is recommended that each medical laboratory establishes and reviews its own RIs. The use of direct methods is often unfeasible for most laboratories, while indirect methods are a more … Read more

Use of indirect methods and machine learning algorithms for the estimation of reference intervals, taking cortisol measurements as an exampleFatma Demet Arslanon October 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-0984. Online ahead of print. ABSTRACT OBJECTIVES: This study aims to determine reliable reference intervals (RIs) for total cortisol (TC) in adults considering the effects of both age and blood collection time, using indirect methods and machine learning approaches. METHODS: Serum TC results from blood samples collected … Read more

Dental amalgams and blood mercury concentrations in American adultsDavid A Geieron October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0909. Online ahead of print. ABSTRACT OBJECTIVES: Dental amalgam (50 % mercury (Hg) by weight) is a commonly used material to restore a tooth damaged by decay. In recent years, amalgam safety has become a matter of ongoing controversy. This hypothesis-testing epidemiological study evaluated the relationship between … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human urineMyriam Otton October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0522. Online ahead of print. ABSTRACT OBJECTIVES: Precise and accurate determination of urinary cortisol is important for diagnosis and monitoring of cortisol excess and deficiency. To achieve this, a selective and specific, isotope-dilution two-dimensional heart-cut liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method was developed. METHODS: A novel, two-dimensional … Read more

Optimization and comparison of genomic DNA extraction from whole blood collected in PAXgene blood RNA tube using automated platformsJianlan Youon October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1079. Online ahead of print. ABSTRACT OBJECTIVES: With the development of genomic technologies, the isolation of genomic DNA (gDNA) from clinical samples has become more important for both clinical diagnostics and research studies. Blood samples collected in PAXgene Blood RNA Tubes, which are typically used for RNA … Read more

An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid in human serum and plasmaTobias Schierscheron October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2024-0860. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid (MPA). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was utilized … Read more

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