Clinical Chemistry and Laboratory Medicine

Impact of renal and hepatic function on dihydropyrimidine dehydrogenase phenotype assessed by enzyme activity in peripheral blood mononuclear cells and uracilemiaSara Contuon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 10. doi: 10.1515/cclm-2025-0949. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the relationship between uracilemia (U) and dihydropyrimidine dehydrogenase (DPD) activity in peripheral blood mononuclear cells (PBMC) and whether they are influenced by renal or hepatic impairment. METHODS: This retrospective study included 176 cancer patients with pre-treatment U (UPLC-MSMS … Read more

Value is equal to outcome/costs: how to apply to laboratory medicineRossella Tomaiuoloon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 10. doi: 10.1515/cclm-2025-0691. Online ahead of print. ABSTRACT The concept of value, defined as health outcomes achieved per monetary unit spent, has profoundly reshaped modern healthcare delivery. While Value-Based Healthcare models have permeated many clinical disciplines, laboratory medicine has been slow to integrate this paradigm shift. In this opinion … Read more

Comparison of seven different enzymatic methods for serum glycated albumin in pregnant women: a multicenter studyDandan Sunon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 10. doi: 10.1515/cclm-2025-0530. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the consistency of seven enzymatic glycated albumin (GA) assays in pregnant women based on a multicenter study. METHODS: Samples were collected from pregnant women at three different gestational stages: 4-13 weeks (n=150), 24-28 weeks (n=300, including 150 GDM … Read more

Proadrenomedullin for prediction of early and mid-term mortality in patients hospitalized for community-acquired pneumoniaAmaia Artarazon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0481. Online ahead of print. ABSTRACT OBJECTIVES: Our study sought to determine the usefulness of biomarkers of systemic inflammation (C-reactive protein (CRP), procalcitonin (PCT) and proadrenomedullin (proADM)) on hospital admission, as compared to the CURB65 score, for predicting 30- and 90-day mortality in patients hospitalized for community … Read more

Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassaysUdit Shethon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0610. Online ahead of print. ABSTRACT OBJECTIVES: Neurofilament light (NfL) is an established biofluid marker of neuroaxonal injury for neurological diseases. Several high-throughput and sensitive immunoassays have been developed to quantify NfL in blood and cerebrospinal fluid (CSF), facilitating the use of NfL as a biomarker in … Read more

Analysis of total cholesterol results measured in the initial period of the Croatian screening program for familial hypercholesterolemia: a pilot studyGordana Juričićon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0536. Online ahead of print. ABSTRACT OBJECTIVES: In 2023, Croatia implemented a screening program for familial hypercholesterolemia (FH) targeting children entering the first grade of primary school. The program is based on total cholesterol (TC) concentration measurements. This pilot study aimed to assess and compare TC results … Read more

Performance evaluation of quantitative hemoglobin A2 and fetal hemoglobin testing using commercially lyophilized vs. in-house whole blood controls in Chinese clinical laboratories: a 12-year analysis of National External Quality Assessment DataYating Maon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0683. Online ahead of print. ABSTRACT OBJECTIVES: To analyze the performance of laboratories in the China National External Quality Assessment Scheme (China NEQAS) for HbA2 and HbF testing, and to propose strategies for quality improvement. METHODS: Data were obtained from China NEQAS from 2013 to 2024 using … Read more

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