Clinical Chemistry and Laboratory Medicine

Improving the efficiency of quality control in clinical laboratory with an integrated PBRTQC system based on patient riskXincen Duanon April 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 4. doi: 10.1515/cclm-2025-0163. Online ahead of print. ABSTRACT OBJECTIVES: Recent advances in information technology have renewed interest in patient-based real-time quality control (PBRTQC) as an alternative to internal quality control (IQC). However, since regulations mandate IQC, PBRTQC can only be implemented as a separate system. The additional labor required … Read more

Consensus instability equations for routine coagulation testsRubén Gómez Riojaon March 29, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 31. doi: 10.1515/cclm-2025-0117. Online ahead of print. ABSTRACT OBJECTIVES: The stability of plasma samples for basic coagulation tests, prothrombin time (PT) and activated partial thromboplastin time (aPTT), has been widely studied. Recently, the Clinical and Laboratory Standards Institute (CLSI) updated its recommendations, extending the acceptable time frame for aPTT. … Read more

Novel Mindray high sensitivity cardiac troponin I assay for single sample and 0/2-hour rule out of myocardial infarction: MERITnI studyKevin G Budaon March 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 25. doi: 10.1515/cclm-2024-1387. Online ahead of print. ABSTRACT OBJECTIVES: We determined the efficacy of a high sensitivity cardiac troponin I (hs-cTnI) assay for newly derived 0 h and 0/2-h rule-out concentrations for myocardial infarction and determined the safety of incremental changes at low concentrations. METHODS: Consecutive, emergency department patients … Read more

Targeted proteomics of serum IGF-I, -II, IGFBP-2, -3, -4, -5, -6 and ALSJakob Albrethsenon March 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 24. doi: 10.1515/cclm-2024-1428. Online ahead of print. ABSTRACT OBJECTIVES: The insulin-like growth factors (IGFs) regulate growth in humans. IGF-I and IGF binding protein (IGFBP)-3 are biomarkers in children with growth disorders. We investigate a targeted proteomics method for absolute quantitation of eight IGF protein family members in human serum, … Read more

Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?Claudia Grossion March 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 21. doi: 10.1515/cclm-2025-0032. Online ahead of print. ABSTRACT OBJECTIVES: The Certified Reference Material (CRM) ERM®-DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated CRM’s ability to represent the heterogeneity of APS patient anti-β2GPI antibodies and … Read more

Reliable detection of sex chromosome abnormalities by quantitative fluorescence polymerase chain reactionCamilla Mains Balleon March 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1400. Online ahead of print. ABSTRACT OBJECTIVES: Many patients with sex chromosome abnormalities (SCAs) are diagnosed late in life or remain undiagnosed, leading to delayed or inadequate medical intervention and care. This study aimed to develop a reliable, rapid and cost-effective test for identifying SCAs using a … Read more

Use of the BIOGROUP® French laboratories database to conduct CKD observational studies: a pilot EPI-CKD1 studyClaire Visseauxon March 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1399. Online ahead of print. ABSTRACT OBJECTIVES: Medical biology is essential for diagnosing and monitoring cardio-reno-metabolic diseases. The EPI-CKD1 study utilizes data from Biogroup® French laboratories to examine the burden of chronic kidney disease (CKD) and the effect of heart failure, and diabetes in an outpatient setting … Read more

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