Clinical Chemistry and Laboratory Medicine

A robust ddPCR assay for the absolute quantification of miR-192-5p in hepatocellular carcinoma liquid biopsiesXinmiao Liuon October 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 31. doi: 10.1515/cclm-2025-0824. Online ahead of print. ABSTRACT OBJECTIVES: MicroRNA-192-5p, a liver-enriched miRNA downregulated in hepatocellular carcinoma (HCC), is a promising biomarker, but its clinical use is limited by technical challenges in detecting low-abundance plasma miRNAs. This study innovatively uses droplet digital PCR (ddPCR) with locked nucleic acid (LNA)-modified … Read more

Short- and medium-term pre-analytical stability of human serum insulin-like growth factor-1Jaco C Louwon October 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 31. doi: 10.1515/cclm-2025-0868. Online ahead of print. ABSTRACT OBJECTIVES: Insulin-like growth factor-1 (IGF-1) is a peptide hormone currently lacking data surrounding its pre-analytical stability. This study aimed to investigate the impact of delaying centrifugation and analysis at different storage temperatures on the in vitro stability of IGF-1. METHODS: The … Read more

Hierarchy of reference interval models: advancing laboratory data interpretationThomas Streicherton October 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 29. doi: 10.1515/cclm-2025-1234. Online ahead of print. ABSTRACT Accurate interpretation of laboratory data is a critical step in clinical decision-making. This requires the availability of reliable reference data for comparison. Reference data can be derived from various sources, including hospital or laboratory databases, groups of reference individuals, or an … Read more

Small-scale external quality assessment of methylated SHOX2 and RASSF1A detection in China: findings from 2023-2024Chengxiang Chuon October 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 29. doi: 10.1515/cclm-2025-0846. Online ahead of print. ABSTRACT OBJECTIVES: DNA methylation in short homeobox gene 2 (SHOX2) and RAS association domain family protein 1 (RASSF1A) shows significant auxiliary diagnostic value for early-stage lung cancer. However, the detection accuracy is frequently compromised because of the complexity of the analytical procedures. … Read more

Development and validation of a machine learning model for accurate detection of wrong blood in tube errors in hospitalized patientsJordi Tortosa-Carrereson October 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 29. doi: 10.1515/cclm-2025-0564. Online ahead of print. ABSTRACT OBJECTIVES: To develop and validate a machine-learning model based on routinely available biochemical and hematological parameters for detecting wrong blood in tube (WBIT) errors in hospitalized patients. METHODS: A retrospective multicenter study including one internal cohort (IC) and two external validation … Read more

Saliva sampling matters for salivary diagnostics of viral infectionsChuixi Kongon October 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 29. doi: 10.1515/cclm-2025-0607. Online ahead of print. ABSTRACT Saliva, a non-invasive biofluid with a variety of biomolecules, has been increasingly recognized as a reliable specimen in the diagnostics of viral infections. Compared to the standard specimens represented by blood and nasopharyngeal swab, saliva is advantageous in non-invasive, simple collection, … Read more

Point of care testing of biochemical markers for monitoring astronauts during long duration missions in deep spaceSimona Ferraroon October 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 28. doi: 10.1515/cclm-2025-0526. Online ahead of print. ABSTRACT BACKGROUND: Investigations into human performance and health status during long-duration spaceflights are ongoing aboard the International Space Station (ISS) and are critical for planning missions beyond Low Earth Orbit (LEO). This review evaluates the current evidence on point-of-care-testing (POCT) in space, … Read more

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