Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0909. Online ahead of print. ABSTRACT OBJECTIVES: Dental amalgam (50 % mercury (Hg) by weight) is a commonly used material to restore a tooth damaged by decay. In recent years, amalgam safety has become a matter of ongoing controversy. This hypothesis-testing epidemiological study evaluated the relationship between … Read more
Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1340. Online ahead of print. NO ABSTRACT PMID:41109962 | DOI:10.1515/cclm-2025-1340
Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0522. Online ahead of print. ABSTRACT OBJECTIVES: Precise and accurate determination of urinary cortisol is important for diagnosis and monitoring of cortisol excess and deficiency. To achieve this, a selective and specific, isotope-dilution two-dimensional heart-cut liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method was developed. METHODS: A novel, two-dimensional … Read more
Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1079. Online ahead of print. ABSTRACT OBJECTIVES: With the development of genomic technologies, the isolation of genomic DNA (gDNA) from clinical samples has become more important for both clinical diagnostics and research studies. Blood samples collected in PAXgene Blood RNA Tubes, which are typically used for RNA … Read more
Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2024-0860. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid (MPA). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was utilized … Read more
Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0938. Online ahead of print. ABSTRACT OBJECTIVES: Automated urine particle analyzers are increasingly employed in clinical laboratories to standardize urinalysis. These systems can reduce workload, turnaround time and the inter-observer variation. This study aimed to assess the performance of five automated urine particle analyzers in detecting and … Read more
Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1032. Online ahead of print. ABSTRACT With the advent of flow cytometry and dedicated fluorescent dyes in the 1980s, automated reticulocyte enumeration has effectively superseded conventional manual microscopy, dramatically boosting throughput and precision while, through metrics including the immature reticulocyte fraction (IRF) and reticulocyte production index (RPI), … Read more
Clin Chem Lab Med. 2025 Oct 16. doi: 10.1515/cclm-2025-1220. Online ahead of print. ABSTRACT The pre-analytical phase of laboratory testing, encompassing processes from test ordering to sample analysis, represents the most error-prone component of laboratory medicine, accounting for 68-98 % of laboratory mistakes. These errors compromise patient safety, increase healthcare costs, and disrupt operational efficiency. … Read more
Clin Chem Lab Med. 2025 Oct 16. doi: 10.1515/cclm-2025-1227. Online ahead of print. NO ABSTRACT PMID:41090558 | DOI:10.1515/cclm-2025-1227
Clin Chem Lab Med. 2025 Oct 14. doi: 10.1515/cclm-2025-1178. Online ahead of print. ABSTRACT OBJECTIVES: The aim of this study is to develop a core competency-based EPAs framework for undergraduate interns in the clinical laboratory. METHODS: The EPAs framework was developed in three stages: formation of a research team, drafting of an initial EPAs framework, … Read more
