Clinical Chemistry and Laboratory Medicine

Impact of delayed centrifugation on the stability of 32 biochemical analytes in blood samples collected in serum gel tubes and stored at room temperatureMaría Sanz-Felision March 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 14. doi: 10.1515/cclm-2025-0109. Online ahead of print. ABSTRACT OBJECTIVES: Evaluate the stability of 32 biochemical analytes in venous blood samples stored at 18-25 °C under different time delays prior to centrifugation. METHODS: A prospective study was conducted involving 33 healthy volunteers. Four venous blood samples were collected from each … Read more

Isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedures for the quantification of 24(R),25-dihydroxyvitamin D2 and 24(R),25-dihydroxyvitamin D3 in human serum and plasmaKerstin Kandleron March 5, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Mar 6. doi: 10.1515/cclm-2024-1139. Online ahead of print. ABSTRACT OBJECTIVES: Isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC MS/MS)-based candidate reference measurement procedures (RMPs) for the quantification of 24,25(OH)2D2 and 24,25(OH)2D3 in human serum and plasma are presented. METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopic methodology was utilized to assign absolute content … Read more

A survey on measurement and reporting of total testosterone, sex hormone-binding globulin and free testosterone in clinical laboratories in EuropeNick Narinxon March 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 12. doi: 10.1515/cclm-2024-1237. Online ahead of print. ABSTRACT OBJECTIVES: To compare clinical laboratory workflows for the assessment of androgens in men, focusing on total testosterone (T), sex hormone-binding globulin (SHBG) and free T, in clinical laboratories throughout Europe. METHODS: An internet-based survey that included questions related to pre-analytical, analytical … Read more

Concordance between the updated Elecsys cerebrospinal fluid immunoassays and amyloid positron emission tomography for Alzheimer’s disease assessment: findings from the Apollo studyHenrik Schinkeon March 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 13. doi: 10.1515/cclm-2024-1476. Online ahead of print. ABSTRACT OBJECTIVES: The Apollo study was designed to support the clinical performance verification of the adjusted cutoffs of the Elecsys® β-Amyloid(1-42) (Aβ42) cerebrospinal fluid (CSF) II, β-Amyloid(1-40) (Aβ40) CSF, Phospho-Tau (181P) (pTau) CSF and Total-Tau (tTau) CSF immunoassays (Roche Diagnostics International Ltd) … Read more

Flow-cytometric MRD detection in pediatric T-ALL: a multicenter AIEOP-BFM consensus-based guided standardized approachMichaela Reiterováon March 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 13. doi: 10.1515/cclm-2024-1503. Online ahead of print. ABSTRACT OBJECTIVES: Risk-based stratification approaches using measurable residual disease (MRD) successfully help to identify T-acute lymphoblastic leukemia (T-ALL) patients at risk of relapse, whose treatment outcomes are very poor. Because of T-ALL heterogeneity and rarity, a reliable and standardized approach for flow … Read more

Unveiling the power of R: a comprehensive perspective for laboratory medicine data analysisChaochao Maon March 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 11. doi: 10.1515/cclm-2024-1193. Online ahead of print. ABSTRACT R language has gained traction in laboratory medicine for its statistical power and dynamic tools like RMarkdown and RShiny. However, there is limited literature summarizing R packages and functions tailored for laboratory medicine, making it difficult for clinical laboratory workers to … Read more

Establishing sex- and age-related reference intervals of serum glial fibrillary acid protein measured by the fully automated lumipulse systemLuisa Agnelloon March 9, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 11. doi: 10.1515/cclm-2025-0093. Online ahead of print. ABSTRACT OBJECTIVES: To establish the reference intervals (RIs) of serum glial fibrillary acid protein (GFAP) measured by the fully automated Lumipulse system. METHODS: The study population consisted of 340 healthy individuals, including 251 blood donors and 89 outpatients, with a median age … Read more

Quality indicators in laboratory medicine: a 2020-2023 experience in a Chinese provinceLichao Zhangon March 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Mar 10. doi: 10.1515/cclm-2024-1457. Online ahead of print. ABSTRACT OBJECTIVES: The identification of reliable quality indicators (QIs) in the total testing process (TTP) is a pivotal step in quantifying laboratory service quality. This study comprehensively evaluated the performance quality and explored the factors affecting laboratory quality in Guangdong Province, China, … Read more

Flow-cytometric lymphocyte subsets enumeration: comparison of single/dual-platform method in clinical laboratory with dual-platform extended PanLeucogating method in reference laboratoryGaofeng Huon March 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Mar 10. doi: 10.1515/cclm-2024-1246. Online ahead of print. ABSTRACT OBJECTIVES: To improve the accuracy of lymphocyte subsets counts, a traceable dual-platform extended PanLeucogating method (DPP) of absolute cell counts of lymphocyte subsets was introduced, and consistency was evaluated by comparing conventional single/dual-platform method with DPP. METHODS: The DPP for absolute … Read more

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