Clinical Chemistry and Laboratory Medicine

Novel protocol for metabolomics data normalization and biomarker discovery in human tearsJoan Serrano-Marínon March 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 19. doi: 10.1515/cclm-2024-1360. Online ahead of print. ABSTRACT OBJECTIVES: Human tear analysis holds promise for biomarker discovery, but its clinical utility is hindered by the lack of standardized reference values, limiting interindividual comparisons. This study aimed at developing a protocol for normalizing metabolomic data from human tears, enhancing its … Read more

Artificial base mismatches-mediated PCR (ABM-PCR) for detecting clinically relevant single-base mutationsCia-Hin Lauon March 15, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 17. doi: 10.1515/cclm-2024-0962. Online ahead of print. ABSTRACT OBJECTIVES: Detecting point mutations with high sensitivity and specificity can be technically very challenging, but it is crucial for early diagnosis and effective drug treatment of cancers. To enable ultrasensitive and ultraspecific detection of single-base mutations in simple and economical ways, … Read more

Impact of biological and genetic features of leukemic cells on the occurrence of “shark fins” in the WPC channel scattergrams of the Sysmex XN hematology analyzers in patients with chronic lymphocytic leukemiaMargot Eggeron March 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 17. doi: 10.1515/cclm-2025-0115. Online ahead of print. ABSTRACT OBJECTIVES: In patients with chronic lymphocytic leukemia (CLL), the white progenitor cell (WPC) channel of the Sysmex XN hematology analyzers typically shows a varying proportion of cells in the upper left field of the scattergram, resembling the shape of shark fins. … Read more

Impact of delayed centrifugation on the stability of 32 biochemical analytes in blood samples collected in serum gel tubes and stored at room temperatureMaría Sanz-Felision March 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 14. doi: 10.1515/cclm-2025-0109. Online ahead of print. ABSTRACT OBJECTIVES: Evaluate the stability of 32 biochemical analytes in venous blood samples stored at 18-25 °C under different time delays prior to centrifugation. METHODS: A prospective study was conducted involving 33 healthy volunteers. Four venous blood samples were collected from each … Read more

Isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedures for the quantification of 24(R),25-dihydroxyvitamin D2 and 24(R),25-dihydroxyvitamin D3 in human serum and plasmaKerstin Kandleron March 5, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Mar 6. doi: 10.1515/cclm-2024-1139. Online ahead of print. ABSTRACT OBJECTIVES: Isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC MS/MS)-based candidate reference measurement procedures (RMPs) for the quantification of 24,25(OH)2D2 and 24,25(OH)2D3 in human serum and plasma are presented. METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopic methodology was utilized to assign absolute content … Read more

A survey on measurement and reporting of total testosterone, sex hormone-binding globulin and free testosterone in clinical laboratories in EuropeNick Narinxon March 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 12. doi: 10.1515/cclm-2024-1237. Online ahead of print. ABSTRACT OBJECTIVES: To compare clinical laboratory workflows for the assessment of androgens in men, focusing on total testosterone (T), sex hormone-binding globulin (SHBG) and free T, in clinical laboratories throughout Europe. METHODS: An internet-based survey that included questions related to pre-analytical, analytical … Read more

Concordance between the updated Elecsys cerebrospinal fluid immunoassays and amyloid positron emission tomography for Alzheimer’s disease assessment: findings from the Apollo studyHenrik Schinkeon March 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 13. doi: 10.1515/cclm-2024-1476. Online ahead of print. ABSTRACT OBJECTIVES: The Apollo study was designed to support the clinical performance verification of the adjusted cutoffs of the Elecsys® β-Amyloid(1-42) (Aβ42) cerebrospinal fluid (CSF) II, β-Amyloid(1-40) (Aβ40) CSF, Phospho-Tau (181P) (pTau) CSF and Total-Tau (tTau) CSF immunoassays (Roche Diagnostics International Ltd) … Read more

Flow-cytometric MRD detection in pediatric T-ALL: a multicenter AIEOP-BFM consensus-based guided standardized approachMichaela Reiterováon March 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 13. doi: 10.1515/cclm-2024-1503. Online ahead of print. ABSTRACT OBJECTIVES: Risk-based stratification approaches using measurable residual disease (MRD) successfully help to identify T-acute lymphoblastic leukemia (T-ALL) patients at risk of relapse, whose treatment outcomes are very poor. Because of T-ALL heterogeneity and rarity, a reliable and standardized approach for flow … Read more

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