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Renal elimination and eGFR prediction of proenkephalin​Johann Sigurjonsson Ulf Nyman Henrik Bjursten David Grubb a Department of Cardiothoracic Anaesthesia and Intensive Care, Skåne University Hospital, Lund University, Lund, Swedenb Department of Translational Medicine, Division of Medical Radiology, Skåne University Hospital, Lund University, Lund, Swedenc Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Swedenon June 10, 2025 at 5:20 am

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Volume 85, Issue 4, JULY 2025, Page 281-286.

A novel modification approach for the one sample Kolmogorov-Smirnov test in large sample size​Ugurcan Sayili Mehmet Guven Gunver a Department of Public Health, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiyeb Department of Biostatistics, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Türkiyec Department of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiyeon June 5, 2025 at 4:35 am

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Volume 85, Issue 4, JULY 2025, Page 287-298.

Comparison of total calprotectin levels with S100A8 and S100A9 subunit levels in critically ill patients​Kristina Sejersen Aleksandra Mandic Havelka Miklos Lipcsey Anders Larsson a Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Swedenb Section of Clinical Chemistry, Unilabs Laboratory Medicine Stockholm, Solna, Swedenc Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Swedend Gentian Diagnostics AB, Stockholm, Swedene Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Swedenf Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Swedenon June 2, 2025 at 5:22 am

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Volume 85, Issue 4, JULY 2025, Page 299-304.

Comparison of serum antinuclear antibodies in Guillain–Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy: a retrospective case–control study​Yu Tu Xuan Gong Jiewei Peng Peipei Zhu Wenyan Zhuo Xueying Yu a Department of Neurology, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, Chinab Department of Endocrinology, Zhuhai People’s Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, Chinac Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, Chinaon May 5, 2025 at 5:19 am

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Volume 85, Issue 4, JULY 2025, Page 242-247.

Impact of preanalytical factors on the stability of acetylcholine receptor antibodies in serum​David Lyse Overgaard Tina Parkner Josefine Jul Jarbæk Nielsen Henning Andersen Cindy Soendersoe Knudsen a Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmarkb Department of Clinical Medicine, Aarhus University, Aarhus, Denmarkc Department of Neurology, Aarhus University Hospital, Aarhus, Denmarkon May 8, 2025 at 6:31 am

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Volume 85, Issue 4, JULY 2025, Page 308-312.

Allele-Specific Digital PCR Enhances Precision and Sensitivity in the Detection and Quantification of Copy Number Alterations in Heterogeneous DNA Samples

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Clin Chem. 2025 Jun 19:hvaf054. doi: 10.1093/clinchem/hvaf054. Online ahead of print. ABSTRACT BACKGROUND: While genetic analyses are vital in cancer diagnostics, measuring copy number (CN) alterations remains challenging, especially in heterogenous samples such as (liquid) biopsies. Using digital PCR, CN alterations are classically studied by comparing the abundances of the target of interest to a … Read more

eGFR Inaccuracy in the Assessment of Living Kidney Transplant Donor Eligibility

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Clin Chem. 2025 Jun 18:hvaf071. doi: 10.1093/clinchem/hvaf071. Online ahead of print. ABSTRACT BACKGROUND: Accurate glomerular filtration rate (GFR) estimation is crucial for evaluating living kidney donors, especially when measured GFR (mGFR) is unavailable. This study compares the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), full age spectrum (FAS), and European Kidney Function Consortium (EKFC) creatinine- and/or … Read more

Comprehensive evaluation of antiphospholipid antibody testing methodologies in APS diagnosis: performance comparisons across assay systems and clinical subtypesYun Wangon June 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 27. doi: 10.1515/cclm-2025-0499. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric complications associated with antiphospholipid antibodies (aPLs). This study aimed to compare the diagnostic performance of six commercial assay systems for detecting aCL and aβ2GPI antibodies. METHODS: Sixty-three APS … Read more

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