ccinfoadmin

Interdisciplinary Collaboration to Develop a Custom Genomic Analysis Pipeline for the Clinical Laboratory: Hepatitis B Virus and Cytomegalovirus Antiviral Resistance Genotyping

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Clin Chem. 2025 Aug 21:hvaf093. doi: 10.1093/clinchem/hvaf093. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing for hepatitis B virus (HBV) and cytomegalovirus (CMV) antiviral drug resistance (AVDR) testing improves the sensitivity of variant detection, but availability of bioinformatics and analytical pipelines are key barriers to implementation. METHODS: Plasma was extracted on MagNA Pure 24 (Roche … Read more

From assessment to action: experience from a quality improvement initiative integrating indicator evaluation and adverse event analysis in a clinical laboratoryPeirong Chenon August 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 21. doi: 10.1515/cclm-2025-0656. Online ahead of print. ABSTRACT OBJECTIVES: ISO 15189:2022 recommends the use of quality indicators (QIs) to monitor laboratory performance and focuses on risk management and continual improvement. This study aims to compare hospital laboratory data with national and international quality specifications and to share experiences in … Read more

Evaluation of measurement uncertainty of 11 serum proteins measured by immunoturbidimetric methods according to ISO/TS 20914: a 1-year laboratory data analysisEmine Feyza Yurton August 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 21. doi: 10.1515/cclm-2025-0654. Online ahead of print. ABSTRACT OBJECTIVES: Measurement uncertainty (MU) plays an important role in the interpretation of laboratory results, but data on serum proteins analyzed by immunoturbidimetry according to ISO/TS 20914 are limited. METHODS: MU of 11 serum proteins, including CRP, RF, ASO, IgG, IgA, IgM, … Read more

Verification of the T50 Calciprotein Crystallization test: bias estimation and interferencesJoyce Y Xuon August 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 20. doi: 10.1515/cclm-2025-0600. Online ahead of print. ABSTRACT OBJECTIVES: The T50 Calciprotein Crystallization test (T50 test) is a novel blood-based in vitro diagnostic assay that determines the calciprotein crystallization time in patients. It is based on the one-half maximum transition time of calciprotein particle 1 (CPP1) to calciprotein particle … Read more

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