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Thiopurine S-methyltransferase (TPMT) activity cutoffs in the Thai population​Pimonpan Jinda, Pimpun Kitpoka, Wimol Thienphopirak, Suwat Chiawchan, Santirhat Prommas, Rattanaporn Sukprasong, Jiratha Rachanakul, Supaporn Wiwattanakul, Orapa Suteerojntrakool, Chansuda Bongsebandhu-phubhakdi, Therdpong Tempark, Sittiphong Hunthai, Apichaya Puangpetch1Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, 26687Mahidol University, Bangkok, Thailand2Division of Blood bank, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, 26687Mahidol University, Bangkok, Thailand3Department of Pathology, Faculty of Medicine, 37693Srinakharinwirot University, Nakornnayok, Thailand4Division of Ambulatory Pediatrics, Department of Pediatrics, Faculty of Medicine, 65103Chulalongkorn University, Bangkok, Thailand5Center of Excellence in Pediatric Nutrition, Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand6Department of Biotechnology, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, Thailandon September 8, 2025 at 12:50 pm

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThiopurine S-methyltransferase (TPMT) is crucial for metabolizing thiopurine drugs. This study aimed to establish the cutoff values for TPMT activity in a cohort of healthy individuals. We defined normal TPMT activity ranges and identified …

Diagnostic accuracy and rapid testing of a novel acute heart failure biomarker: A laboratory evaluation and comparison with natriuretic peptides​Kevin Rouet, Philippe Rouet, François Koukoui, Michel Galinier1Association pour le Développement de la Recherche en Cardiologie Moléculaire et Clinique, Clermont le Fort, France2Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania3Department of Surgical Oncology, Regional Institute of Oncology (IRO), Iasi, Romania455461Service de Réadaptation Cardiaque Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France5Department of Cardiology, 665182Toulouse University Hospital, Toulouse, Franceon August 29, 2025 at 1:31 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundDiagnosing acute heart failure in patients presenting with acute dyspnea remains challenging. Current methods, including natriuretic peptide measurement and echocardiography, are time-consuming and not always immediately accessible. A novel …

Procalcitonin assay variation in an Australasian external quality assurance program​Alexander Richardson, Kristie Chapman, Peter Graham, Tony Badrick1Royal College of Pathologists of Australasia Quality Assurance Programs, NSW, Australia2Department of Clinical Immunology, 2205Royal Prince Alfred Hospital, NSW, Australiaon August 14, 2025 at 12:54 pm

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Annals of Clinical Biochemistry, Ahead of Print. Sepsis accounts for approximately 20% of global deaths, and early diagnosis is a critical factor in intervention. In 2017, the FDA approved procalcitonin (PCT) to guide antibiotic use for patients with suspected sepsis, and there are recognized intervals …

Quantitative effects of bilirubin photoisomers on the measurement of direct bilirubin by the enzymatic bilirubin oxidase method​Nana Kawaguchi, Kosuke Koyano, Hirosuke Morita, Dk Nur Rosyiidah Apryll Czarina Pengiran Mohamad Fadly, Yuta Shinabe, Yuta Noguchi, Makoto Arioka, Yasuhiro Nakao, Miyo Ozaki, Shinji Nakamura, Sonoko Kondo, Yukihiko Konishi, Toru Kuboi, Hitoshi Okada, Saneyuki Yasuda, Susumu Itoh, Koji Murao, Takashi Kusaka1Division of Neonatology, 36983NHO Shikoku Medical Center for Children and Adults, Kagawa, Japan2Department of Pediatrics, Faculty of Medicine, 12850Kagawa University, Kagawa, Japan3Faculty of Biomedical Science, 483064Universiti Brunei Darussalam, Brunei Darussalam4Department of Clinical Laboratory, Faculty of Medicine, 12850Kagawa University, Kagawa, Japan5Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, Japanon July 29, 2025 at 3:36 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundBilirubin photoisomers, generated during phototherapy or incidental light exposure, may interfere with direct bilirubin (DB) measurement using the bilirubin oxidase method. This interference is particularly relevant in neonates, who …

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