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Metamizole (dipyrone) as an interferent in biochemical assays​David Ceacero-Marín, Lídia Martínez-Zamorano, Adrían Gisbert-Alonso, Isabel Cachón-Suárez, Karla Gabriela Mendoza-Javier, María José Castro-CastroBiochemistry Core of the Clinical Laboratory, 16383Bellvitge University Hospital, Barcelona, Spainon March 5, 2025 at 2:46 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundMetamizole (MMZ), commonly used as an analgesic/antipyretic in countries like Spain, faces restrictions elsewhere due to side effects. Despite this, its frequent use underscores the critical importance of studying its impact on the accuracy of …

Carbamylated Albumin, Heart Failure, and Mortality in Patients Undergoing Coronary Angiography

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Clin Chem. 2025 Mar 19:hvaf021. doi: 10.1093/clinchem/hvaf021. Online ahead of print. ABSTRACT BACKGROUND: Urea is elevated in chronic kidney disease (CKD) and end-stage renal disease (ESRD), and promotes the carbamylation of proteins, including human albumin, on multiple lysine side chains. Higher proportions of carbamylated albumin (C-Alb) have been associated with increased mortality risk in patients … Read more

Pediatric Vaccine-Induced Antibody Thresholds: Rethinking Pre-Immunosuppression Serologic Testing and Revaccination Implications

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Clin Chem. 2025 Mar 19:hvaf020. doi: 10.1093/clinchem/hvaf020. Online ahead of print. ABSTRACT BACKGROUND: Immune response to vaccination is assessed when adequate vaccine protection is in question or immunosuppression is imminent through measurement of antibody levels, which wane as time from vaccination increases. The serologic cutoff value for adequate response is based on thresholds derived from … Read more

Reliable detection of sex chromosome abnormalities by quantitative fluorescence polymerase chain reactionCamilla Mains Balleon March 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1400. Online ahead of print. ABSTRACT OBJECTIVES: Many patients with sex chromosome abnormalities (SCAs) are diagnosed late in life or remain undiagnosed, leading to delayed or inadequate medical intervention and care. This study aimed to develop a reliable, rapid and cost-effective test for identifying SCAs using a … Read more

Use of the BIOGROUP® French laboratories database to conduct CKD observational studies: a pilot EPI-CKD1 studyClaire Visseauxon March 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1399. Online ahead of print. ABSTRACT OBJECTIVES: Medical biology is essential for diagnosing and monitoring cardio-reno-metabolic diseases. The EPI-CKD1 study utilizes data from Biogroup® French laboratories to examine the burden of chronic kidney disease (CKD) and the effect of heart failure, and diabetes in an outpatient setting … Read more

Novel protocol for metabolomics data normalization and biomarker discovery in human tearsJoan Serrano-Marínon March 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 19. doi: 10.1515/cclm-2024-1360. Online ahead of print. ABSTRACT OBJECTIVES: Human tear analysis holds promise for biomarker discovery, but its clinical utility is hindered by the lack of standardized reference values, limiting interindividual comparisons. This study aimed at developing a protocol for normalizing metabolomic data from human tears, enhancing its … Read more

Exploratory study on reference intervals of calprotectin and pentraxin 3​Igor Alfirevic, Andrea Saracevic, Helena Cicak, Hrvoje Galic, Vanja Radisic Biljak, Ana-Maria Simundic1University Department of Surgery, University Hospital Sveti Duh, Zagreb, Croatia2Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia3University North, Varazdin, Croatia4Department of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia5Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia6Department of Global Medical and Clinical Affairs, 31310Greiner Bio-One, Kremsmünster, Austria7Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatiaon December 9, 2024 at 10:32 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionThe aim of our study was to determine reference intervals for serum pentraxin 3 and calprotectin, as well as for urine calprotectin according to the CLSI EP28-A3C guidelines for defining, establishing, and verifying reference intervals in the …

The diagnostic and prognostic value of serum angiopoietin-like 4 level in neonatal respiratory distress syndrome​Xiuyun SongDepartment of Neonatology, 159406Children’s Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, Chinaon January 13, 2025 at 2:36 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesNeonatal respiratory distress syndrome (NRDS) is the most common respiratory disease in preterm infants (PIs). The implication of Angiopoietin-like 4 (ANGPTL4) was reported in lung diseases. We delved into the role of serum ANGPTL4 in NRDS …

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