ccinfoadmin

Novel Mindray high sensitivity cardiac troponin I assay for single sample and 0/2-hour rule out of myocardial infarction: MERITnI studyKevin G Budaon March 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 25. doi: 10.1515/cclm-2024-1387. Online ahead of print. ABSTRACT OBJECTIVES: We determined the efficacy of a high sensitivity cardiac troponin I (hs-cTnI) assay for newly derived 0 h and 0/2-h rule-out concentrations for myocardial infarction and determined the safety of incremental changes at low concentrations. METHODS: Consecutive, emergency department patients … Read more

Targeted proteomics of serum IGF-I, -II, IGFBP-2, -3, -4, -5, -6 and ALSJakob Albrethsenon March 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 24. doi: 10.1515/cclm-2024-1428. Online ahead of print. ABSTRACT OBJECTIVES: The insulin-like growth factors (IGFs) regulate growth in humans. IGF-I and IGF binding protein (IGFBP)-3 are biomarkers in children with growth disorders. We investigate a targeted proteomics method for absolute quantitation of eight IGF protein family members in human serum, … Read more

Decrease in the internal quality control intermediate reproducibility imprecision of Cystatin C results in China in the years from 2014 to 2023​Zhixin Zhang, Jie Zeng, Wei Wang, Yuxuan Du, Shuai Yuan, Na Dong, Chuanbao Zhang, Zhiguo WangNational Center for Clinical Laboratories/Beijing Engineering Research Center of Laboratory Medicine, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, Chinaon March 14, 2025 at 4:39 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesWe evaluated the intermediate reproducibility imprecision of cystatin C results based on internal quality control (IQC) data.MethodsIQC data for cystatin C analyte were collected each year from 2014 to 2023. We used the coefficient of variation (…

Preβ1-high-density lipoprotein binds to TG-rich lipoproteins and its release is impaired in the postprandial state among patients with poorly controlled type 2 diabetes​Yuna Horiuchi, Satoshi Hirayama, Atsushi Hori, Yuri Ichikawa, Satoshi Soda, Utako Seino, Kazumasa Sekihara, Tsuyoshi Ueno, Yoshifumi Fukushima, Katsuo Kubono, Takashi Miida1Department of Clinical Laboratory Technology, 12847Juntendo University Faculty of Medical Science, Urayasu, Japan2Department of Clinical Laboratory Medicine, 12847Juntendo University Graduate School of Medicine, Tokyo, Japan3Health Service Center, Tokyo Gakugei University, Tokyo, Japan4Department of Endocrinology and Metabolism, 26834Niigata City General Hospital, Niigata, Japan5Division of Clinical Laboratory, 679868Misono Hospital, Niigata, Japan6Department of Pharmacology, Faculty of Medicine, 12952University of Miyazaki, Miyazaki, Japanon March 5, 2025 at 2:53 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundAlthough preβ1-high-density lipoprotein (preβ1-HDL) promotes cholesterol efflux, high fasting preβ1-high-density lipoprotein levels after breakfast are reduced in patients with poorly controlled type 2 diabetes.ObjectiveThis study investigated …

Determinants of Cardiac Myosin Binding Protein C in the General Population

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Clin Chem. 2025 Mar 20:hvaf013. doi: 10.1093/clinchem/hvaf013. Online ahead of print. ABSTRACT BACKGROUND: Cardiac myosin binding protein C (cMyC) is a novel, cardiac-specific biomarker with an early release profile after acute ischemic myocardial injury. Whether cMyC reflects chronic myocardial injury and left ventricular remodelling in the general population is unknown. The aims of the study … Read more

Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?Claudia Grossion March 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 21. doi: 10.1515/cclm-2025-0032. Online ahead of print. ABSTRACT OBJECTIVES: The Certified Reference Material (CRM) ERM®-DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated CRM’s ability to represent the heterogeneity of APS patient anti-β2GPI antibodies and … Read more

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