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Impact of renal function impairment on kappa free light chain indexMartin Schmidaueron April 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0007. Online ahead of print. ABSTRACT OBJECTIVES: To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. METHODS: Patients with non-inflammatory neurological diseases were eligible. κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin quotient. Structural equation modeling (SEM) was used to evaluate the direct influence … Read more

The accuracy of presepsin in diagnosing neonatal late-onset sepsis in critically ill neonates: a prospective studyCinzia Aurition April 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0128. Online ahead of print. ABSTRACT OBJECTIVES: The diagnostic accuracy of presepsin (P-SEP) in the newborn is still under evaluation. METHODS: In a multicenter study, we studied the accuracy of P-SEP as a diagnostic marker of late-onset sepsis (LOS) in critical newborns with underlying disorders, to define … Read more

Evaluation of error detection and treatment recommendations in nucleic acid test reports using ChatGPT modelsWenzheng Hanon April 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0089. Online ahead of print. ABSTRACT OBJECTIVES: Accurate medical laboratory reports are essential for delivering high-quality healthcare. Recently, advanced artificial intelligence models, such as those in the ChatGPT series, have shown considerable promise in this domain. This study assessed the performance of specific GPT models-namely, 4o, o1, … Read more

A Comprehensive Review of Estradiol, Progesterone, Luteinizing Hormone, and Follicle-Stimulating Hormone in the Context of Laboratory Medicine to Support Women’s Health

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Clin Chem. 2025 Apr 18:hvaf039. doi: 10.1093/clinchem/hvaf039. Online ahead of print. ABSTRACT BACKGROUND: There have been conflicting messages about the influence of female sex hormones on women’s health, with historical messaging indicating that use of estrogen and/or progesterone in peri- or postmenopause poses a significant clinical risk to cisgender women. More recent guidance indicates that … Read more

Direct screening and quantification of monoclonal immunoglobulins in serum using MALDI-TOF mass spectrometry without antibody enrichmentHou-Long Luoon April 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 18. doi: 10.1515/cclm-2025-0203. Online ahead of print. ABSTRACT OBJECTIVES: Monoclonal gammopathies (MGs) are characterized by the presence of monoclonal immunoglobulins (M-proteins). Currently, recommendations for screening of MGs primarily rely on nephelometry, turbidimetry and electrophoresis, which have inherent limitations in sensitivity and throughput. This study aimed to evaluate a novel … Read more

A simpler and more sensitive modified catalytic (bleomycin detectable) iron assay​Mohan M Rajapurkar, Banibrata Mukhopadhyay, Suhas S Lele, Sudhir V Shah129025Muljibhai Patel Urological Hospital, Nadiad, India212215University of Arkansas for Medical Sciences, Little Rock, AR, USAon March 14, 2025 at 4:48 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundIron is ubiquitously distributed in biology, only a miniscule amount exists as free is capable of catalysing production of highly toxic reactive hydroxyl radicle. This free iron also called; labile iron, non-transferrin bound iron or catalytic …

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