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Detection of Advanced Liver Fibrosis Using Blood Noninvasive Tests: A Laboratory Medicine Perspective

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Clin Chem. 2026 Feb 3:hvaf193. doi: 10.1093/clinchem/hvaf193. Online ahead of print. ABSTRACT BACKGROUND: Despite its growing impact, advanced liver fibrosis (ALF) remains substantially underdiagnosed in both primary and specialized care settings. Since liver cirrhosis is typically preceded by a prolonged phase of asymptomatic fibrosis, early detection of ALF, particularly in high-risk individuals, represents a public … Read more

Antiphosphatidylserine/prothrombin antibodies define a high-risk antiphospholipid syndrome profile associated with organ damageAriela Hoxhaon February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1565. Online ahead of print. ABSTRACT OBJECTIVES: Antiphosphatidylserine/prothrombin (aPS/PT) antibodies are promising non-criteria aPLs associated with antiphospholipid syndrome (APS) manifestations. Their influence on long-term outcomes and damage remains uncertain. To assess aPS/PT antibodies association with accrual damage and severe APS disease phenotypes, focusing on their potential for … Read more

Blood biomarkers in neurodegenerative diseases: pre-analytical, analytical, and post-analytical challengesConstance Delabyon February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1731. Online ahead of print. ABSTRACT Recent advances in blood-based biomarkers for neurodegenerative diseases present promising opportunities for earlier diagnosis and more effective disease monitoring. However, challenges in standardizing sample collection, processing protocols, and data reporting continue to hinder reproducibility, limit cross-study comparability, and delay clinical adoption. … Read more

Green laboratory through test ordering appropriateness and innovationSveva Stangalinion February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1606. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratories play a vital role in healthcare but are also among the most resource-intensive hospital units. High energy and water consumption, extensive use of single-use plastics, and the generation of non-recyclable biomedical waste present major environmental challenges. This study … Read more

Implementation of AI systems in the clinical laboratory: insights from an expert survey and recommendations for best practiceHe S Yangon February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1322. Online ahead of print. ABSTRACT OBJECTIVES: Despite growing interest in artificial intelligence (AI) and machine learning (ML), many laboratory professionals lack experience with developing in-house AI systems or implementing those supplied by external providers. The IFCC Committee on AI in Laboratory Medicine (C-AILM) conducted a survey … Read more

Discovery of an Artificial Intelligence Label Feedback Loop: How the Success of a Clinically Implemented Artificial Intelligence Algorithm Has Created an Unforeseen Challenge to Algorithm Retraining

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Clin Chem. 2026 Feb 2:hvag001. doi: 10.1093/clinchem/hvag001. Online ahead of print. ABSTRACT BACKGROUND: Artificial intelligence (AI) augmented laboratory tests can improve quality, efficiency, cost-effectiveness, and staff satisfaction. However, the clinical success of these tests can introduce unforeseen challenges for model retraining. This study describes the discovery of an “AI label feedback loop” in a clinically … Read more

Bioequivalence of C-reactive protein in fingerprick blood and serum measured using the point-of-care LumiraDx test for tuberculosis diagnosis in exposed contacts​on February 2, 2026 at 2:00 pm

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Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Arthur M. Chiwaya, Shima M. Abdulgader, Patricia Manjate, James Sserubiri, Bayanda Mdoda, Loide N.N. Shipingana, Dinis Nguenha, Derrick Semugenze, Marc Bañuls, Vinzeigh N. Leukes, Adam Penn-Nicholson, Achilles Katamba, Moses Joloba, Willy Ssengooba, Alberto L. García-Basteiro, Frank Cobelens, Grant Theron  

Laboratory solution to diagnose and monitor atypical IgG4-mediated anti-GBM diseaseJoannes F M Jacobson February 1, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 2. doi: 10.1515/cclm-2025-1499. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing atypical IgG4-mediated anti-glomerular basement membrane (anti-GBM) disease is challenging because conventional serological assays poorly detect IgG4 antibodies. Here we study which commercial assays are affected and we describe proof-of-concept of improved IgG4 anti-GBM detection. METHODS: To investigate the scope … Read more

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