Adv Lab Med. 2025 Jul 17;6(4):442-449. doi: 10.1515/almed-2025-0023. eCollection 2025 Dec. ABSTRACT OBJECTIVES: Prostate-specific antigen (PSA) circulates bound to extracelular vesicles (EVs). Levels of this PSA form (ev-PSA) are higher in prostate cancer (PCa) compared to benign pathologies and healthy controls, being the PSA extracellular vesicles/serum (ev/srm) ratio potentially useful as PCa diagnostic biomarker. We … Read more
Adv Lab Med. 2025 Jul 18;6(4):458-466. doi: 10.1515/almed-2024-0210. eCollection 2025 Dec. ABSTRACT OBJECTIVES: Emergency department (ED) crowding is a quality of care and financial problem. Among its causes are long length of stay in the ED (ED LoS). One of identified causes is prolonged Turnaround Time (TAT) for complementary tests, including laboratory tests. The main … Read more
Adv Lab Med. 2025 Jun 4;6(4):411-418. doi: 10.1515/almed-2025-0008. eCollection 2025 Dec. ABSTRACT OBJECTIVES: Various analyzers are available for measuring first-trimester combined screening for trisomy 21 (T21) serum biomarkers (free-beta subunit of the human chorionic gonadotropin (β-hCG) and the pregnancy-associated plasma protein A (PAPP-A)). Our aim is to compare the analytical performance of four different analyzers … Read more
Adv Lab Med. 2025 May 1;6(3):345-350. doi: 10.1515/almed-2024-0068. eCollection 2025 Sep. ABSTRACT OBJECTIVES: The determination of urinary albumin, crucial for chronic kidney disease (CKD) diagnosis and monitoring, typically employs quantitative techniques as the gold standard. However, semi-quantitative methods such as urine reagent strips show promise as cost-effective and rapid screening tools. This study aims to … Read more
Adv Lab Med. 2025 May 5;6(3):358-364. doi: 10.1515/almed-2024-0202. eCollection 2025 Sep. ABSTRACT OBJECTIVES: Disease monitoring in acute leukemia management is crucial for risk stratification and chemotherapy response assessment. Minimal residual disease (MRD) testing is the most reliable tool, measuring antigenic expression differences between leukemic cells, hematogones, and mature benign B-cells. Modulation of antigen expression during … Read more
Adv Lab Med. 2025 Apr 21;6(2):199-205. doi: 10.1515/almed-2025-0067. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Quality indicators (QIs) are a valuable tool for monitoring and improving extra-analytical phase performance in the clinical laboratory (CL). For that reason, the Spanish Society of Laboratory Medicine (SEQCML) launched its Pre-analytical Phase EQA Program in 2001. METHODS: In 2023, a survey … Read more
Adv Lab Med. 2025 Mar 20;6(2):166-172. doi: 10.1515/almed-2024-0206. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Lipemia poses a significant preanalytical problem for complete blood count (CBC) measurement due to limited and non-standardized methods for recognition and removal. We aimed to verify the optical hemoglobin (Hb-O) measurements on the Sysmex XN-1000 hematology analyzer (HA) as a possible reliable … Read more
Adv Lab Med. 2025 Jan 23;6(2):213-216. doi: 10.1515/almed-2024-0175. eCollection 2025 Jun. ABSTRACT OBJECTIVES: Hemoglobinopathies are disorders affecting the structure, function and/or production of hemoglobin. These conditions are caused by mutations in the genes encoding globin synthesis. The highly variable clinical manifestations of hemoglobin disorders range from asymptomatic forms to severe anemia. Laboratory tests are crucial … Read more
Adv Lab Med. 2025 Apr 1;6(2):154-159. doi: 10.1515/almed-2025-0042. eCollection 2025 Jun. ABSTRACT INTRODUCTION: Data science is an umbrella term encompassing a set of tools and processes that make it possible to extract new information from structured or unstructured databases. This scientific discipline is gaining relevance in healthcare. In the clinical laboratory, the multiple applications of … Read more
Adv Lab Med. 2025 Mar 10;6(1):28-36. doi: 10.1515/almed-2025-0031. eCollection 2025 Mar. ABSTRACT OBJECTIVES: To evaluate seven bioinformatics platforms for automated AI-based genomic variant prioritization and classification. METHODS: An evaluation was performed of 24 genetic variants that explained the phenotype of 20 patients. FASTQ files were simultaneously uploaded on the following bioinformatics platforms: Emedgene, eVai, Varsome … Read more
Adv Lab Med. 2025 Feb 4;6(1):98-102. doi: 10.1515/almed-2025-0003. eCollection 2025 Mar. ABSTRACT OBJECTIVES: Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by peripheral blood cytopenias, cellular dysplasia and risk for progression into acute leukemia. Recent studies reveal that some research parameters available on Sysmex XN-1000® hematology analyzers, including immature platelet fraction (IPF), Neutrophil Granularity Index … Read more
Adv Lab Med. 2025 Mar 7;6(1):46-51. doi: 10.1515/almed-2025-0011. eCollection 2025 Mar. ABSTRACT OBJECTIVES: To prospectively examine the ability of some glycemic variability metrics from continuous glucose monitoring (CGM) to predict the development of diabetes in a non-diabetic population. METHODS: A total of 497 non-diabetic patients from the AEGIS study were included. Participants used a CGM … Read more
Adv Lab Med. 2024 Nov 21;6(1):108-112. doi: 10.1515/almed-2024-0170. eCollection 2025 Mar. ABSTRACT OBJECTIVES: Centrifugation is a key process that should be controlled to ensure an adequate sample quality. To achieve rapid, standardized, and consistent sample centrifugation, we aimed to evaluate an alternative centrifugation protocol and its impact on the results of 20 biochemical determinations in … Read more
Adv Lab Med. 2025 Jan 3;6(1):59-68. doi: 10.1515/almed-2024-0080. eCollection 2025 Mar. ABSTRACT OBJECTIVES: Reference intervals (RI) are an essential tool to support clinical decisions. These may have intra- and inter-individual variations associated with genetic differences and environmental factors. Given that Chile is a multiethnic territory, studying these variables is even more relevant. The purpose of … Read more
Adv Lab Med. 2024 Aug 22;5(4):356-365. doi: 10.1515/almed-2024-0109. eCollection 2024 Dec. ABSTRACT INTRODUCTION: Retrograde ejaculation (RE) consists of the reflux backwards, towards the bladder, of the ejaculate, during the emission phase of ejaculation, causing a total or partial absence of sperm emission, with the consequent diversion of semen into the bladder during the emission phase … Read more
Adv Lab Med. 2024 Jul 12;5(4):386-393. doi: 10.1515/almed-2024-0041. eCollection 2024 Dec. ABSTRACT OBJECTIVES: The presence of macro-B12 is a cause of factual hypervitaminemia B12. Precipitation with polyethylene glycol (PEG) is a simple method of removing high-molecular-weight biomolecules. However, “free” molecule may co-precipitate. This fact requires the establishment of reference intervals for the post-precipitation result. The … Read more
Adv Lab Med. 2024 Nov 7;5(4):425-431. doi: 10.1515/almed-2024-0146. eCollection 2024 Dec. ABSTRACT OBJECTIVES: Genetic variants with associated pharmacokinetic and pharmacodynamic effects have an impact on the development of adverse drug reactions and survival of patients with colorectal cancer. METHODS: A selection of genetic variants was performed according to the established chemotherapy and the pharmacogenetic databases. … Read more
Adv Lab Med. 2024 Aug 26;5(4):402-406. doi: 10.1515/almed-2024-0089. eCollection 2024 Dec. ABSTRACT OBJECTIVES: Semen analysis investigates different parameters of human semen with a high relevance in fertility workup, confirmation of sterility by post vasectomy, in pathologies follow-up such as varicocele and in all cases where sperm preservation is required. Manually seminal fluid examination is characterized … Read more
Adv Lab Med. 2024 Nov 26;5(4):381-385. doi: 10.1515/almed-2024-0181. eCollection 2024 Dec. ABSTRACT OBJETIVOS: El análisis de orina es ampliamente utilizado y frecuentemente solicitado desde los servicios de urgencias para evaluar la presencia de hipovolemia, infecciones del tracto urinario, diabetes, cetoacidosis y hematuria. Nuestro objetivo era evaluar el impacto de informar el sedimento urinario en muestras … Read more
Adv Lab Med. 2024 Dec 10;5(4):443-446. doi: 10.1515/almed-2024-0184. eCollection 2024 Dec. ABSTRACT OBJETIVOS: Las pruebas de laboratorio resultan cruciales en el diagnóstico de las gammapatías monoclonales. La última actualización de la guía del Grupo Internacional de Trabajo sobre el Mieloma (IMWG) para el diagnóstico de gammapatías monoclonales ha suscitado cierto debate sobre la pertinencia de … Read more
Adv Lab Med. 2024 Nov 8;5(4):451-454. doi: 10.1515/almed-2024-0143. eCollection 2024 Dec. ABSTRACT OBJETIVOS: Describir la variante de hemoglobina que interfiere en el análisis de HbA1c mediante HPLC de intercambio catiónico. CASO CLÍNICO: Paciente de 78 años que acude a consulta de Medicina Interna para una revisión rutinaria, donde se incluye la determinación de HbA1c para … Read more
Adv Lab Med. 2024 Jul 12;5(4):377-380. doi: 10.1515/almed-2024-0035. eCollection 2024 Dec. ABSTRACT OBJECTIVES: Urinalysis is widely used and is also frequently requested in emergency situations for screening hypovolemia, urinary tract infections, diabetes, ketoacidosis and hematuria. Our aim was to evaluate the impact of reporting urinary sediment in emergency department specimens with the Sysmex UN system. … Read more
Adv Lab Med. 2024 Nov 27;5(4):418-424. doi: 10.1515/almed-2024-0172. eCollection 2024 Dec. ABSTRACT OBJETIVOS: Las mutaciones dominio quinasa BCR-ABL1 son una de las principales causas de resistencia a los inhibidores de la tirosina quinasa (ITK) en la leucemia mieloide crónica (LMC), siendo la mutación T315I la más resistente a tratamiento. El objetivo del presente estudio es … Read more
