Journal

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practiceLuisa Agnelloon September 2, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1113. Online ahead of print. ABSTRACT Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, therapeutic decision-making, and longitudinal disease monitoring. To effectively support clinical decision-making, … Read more

Lipoprotein(a) measurement: challenges and opportunitiesJohn H Contoison September 2, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1262. Online ahead of print. ABSTRACT Lipoprotein(a) [Lp(a)] is a causal, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. New guidelines recommend testing everyone at least once in a lifetime, and with new drugs specifically targeting Lp(a) on the horizon, accurate measurement remains … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of piperacillin in human serum and plasmaSandra Fleischeron September 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0427. Online ahead of print. ABSTRACT OBJECTIVES: Piperacillin is a broad-spectrum antibiotic used to treat critically ill patients with severe infections, requiring therapeutic drug monitoring (TDM). We report the development of an isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure (RMP) to quantify piperacillin in human … Read more

Optimal Positive Control Assays for Methylation-Specific PCR

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Clin Chem. 2026 Sep 1:hvag097. doi: 10.1093/clinchem/hvag097. Online ahead of print. ABSTRACT BACKGROUND: Methylation-specific PCR (MSP) is widely used in cancer diagnostics and requires positive controls to confirm DNA integrity and bisulfite conversion. Positive control assays include conversion-specific PCR (CSP) and cytosine-free fragment (CFF) assays. Despite their ubiquity and critical need in MSP assays, positive … Read more

Correlated seasonal dyskalaemia in a primary care population: winter hyperkalaemia and summer hypokalaemiaAmro Maaroufon August 31, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0333. Online ahead of print. ABSTRACT OBJECTIVES: In vitro serum potassium is affected by ambient temperature with peaks in the winter and troughs in the summer. We investigated whether primary care phlebotomy locations with higher winter hyperkalaemia rates exhibited higher summer hypokalaemia and evaluated a simple screening … Read more

A diagnostic strategy for primary aldosteronism diagnosis based on urinary aldosterone assayZhangwei Gaoon August 31, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0865. Online ahead of print. ABSTRACT OBJECTIVES: To compare 24-h urinary excretion of aldosterone (24-h UEA) measured by competitive chemiluminescent immunoassay (cCLIA) and sandwich chemiluminescent immunoassay (sCLIA) with liquid chromatography-tandem mass spectrometry (LC-MS/MS), and to evaluate a direct renin concentration (DRC)-stratified interpretive strategy for primary aldosteronism (PA). … Read more

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