Journal

Automation of sample preparation workflow for trace elements testing by ICP-MS/MSDifei Sunon July 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 13. doi: 10.1515/cclm-2026-0647. Online ahead of print. ABSTRACT OBJECTIVES: Inductively coupled plasma-mass spectrometry (ICP-MS) is a gold standard for testing trace elements. Despite its wide adoption in clinical laboratories, sample preparation workflows are typically manual and prone to environmental contamination. The objective of this study was to develop an … Read more

Serum Biomarkers for the Non-Invasive Assessment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An Update

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Clin Chem. 2026 Jul 10:hvag077. doi: 10.1093/clinchem/hvag077. Online ahead of print. ABSTRACT BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, represents the leading cause of chronic liver disease globally. The increasing prevalence of the metabolic syndrome has driven a parallel rise in MASLD-related morbidity and mortality. Accurate assessment of … Read more

Looking back to look forward: can analytical performance be successfully linked to health outcomes in laboratory medicine?Katy J L Bellon July 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0643. Online ahead of print. ABSTRACT The 2015 Milan consensus proposed three models for analytical performance (APS) specifications for laboratory tests. Model 1 recommends defining analytical performance specifications based on impact on clinical outcomes. We undertook a targeted literature review to identify and evaluate studies using indirect … Read more

Clinical validation of an automated extraction protocol and liquid chromatography single quadrupole mass spectrometry (LC-MS) method for plasma vitamins A and E analysisRowan Hellieron July 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0108. Online ahead of print. ABSTRACT OBJECTIVES: Quantitation of plasma vitamins A and E is essential for assessing nutritional status. Traditional methods typically involve liquid-liquid extraction followed by high-performance liquid chromatography with UV detection (HPLC-UV). In this study, we evaluated an automated sample extraction-method paired with liquid … Read more

Impact of a computerized intervention to optimize laboratory tests ordering: one-year follow-up in a geriatric unitEdith Rengueton July 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0938. Online ahead of print. ABSTRACT OBJECTIVES: Approximately 30 % of laboratory tests are ordered inappropriately, substantially impacting patient care, costs, and carbon footprint of laboratories. Predefined laboratory test panels are a pragmatic and routinely used tool in laboratories, where tests are bundled for efficiency to diagnose … Read more

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