Journal

Serum protein electrophoresis pattern associated with elevated polyclonal IgG4 concentrations: a monoclonal-mimicking profile with potentially significant clinical implicationsLaura Michettion March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0183. Online ahead of print. ABSTRACT OBJECTIVES: To estimate the frequency and characterize the distinctive features of the serum electrophoretic pattern associated with polyclonal elevations of IgG4, and to evaluate its clinical relevance. METHODS: A total of 127,827 serum protein electrophoresis (SPEP) analyses performed in our laboratory … Read more

Representation and performance of CE-marked and in-house in vitro diagnostic tests for routine laboratory parameters in external quality assessment programmesChristoph Buchtaon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 17. doi: 10.1515/cclm-2026-0288. Online ahead of print. ABSTRACT OBJECTIVES: European legislation requires detailed performance evaluation of in vitro diagnostic medical devices (IVD-MD) by both commercial manufacturers (through the Conformité Européenne (CE) mark) and in-house (IH) IVDs. Little information is currently available on how CE- and IH-IVDs are mapped in … Read more

Current practices and harmonization challenges in Alzheimer’s disease biomarkers: an EFLM Committee: Harmonization SurveyLuisa Agnelloon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0168. Online ahead of print. ABSTRACT OBJECTIVES: Fluid biomarkers are central to the biological definition and diagnosis of Alzheimer’s disease (AD). Despite international recommendations, substantial variability persists in laboratory practices. This survey, promoted by the Committee: Harmonisation (C:H) of the European Federation of Clinical Chemistry and Laboratory … Read more

Serum as an alternative to plasma for determining the ApoE4 phenotype using Pan-ApoE and ApoE4 chemiluminescent enzyme immunoassaysEric Kortmannon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0032. Online ahead of print. ABSTRACT OBJECTIVES: Since apolipoprotein E4 (ApoE4) is associated with therapy-related adverse effects of anti-amyloid-β monoclonal antibodies in Alzheimer’s disease, such as amyloid-related imaging abnormalities, methods for determining the ApoE4 status are needed. The Lumipulse® ApoE4 and Pan-ApoE assays provide a practical approach, … Read more

Recommendations for establishing metrological traceability for in vitro diagnostic measurement procedures intended to be used for whole blood samples​on March 17, 2026 at 6:39 pm

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Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Jesper V. Johansen, Cas Weykamp, Elizabeth Barczak, Kevin Horan, Sverre Sandberg, Liesbet Deprez, Vincent Delatour, Mauro Panteghini, Neil Greenberg, Jeffrey Budd, Finlay MacKenzie, W. Greg Miller, for the IFCC Working Group on Commutability in Metrological Traceability  

Extracellular vesicles in cardiovascular disease: Biomarkers, therapeutic applications, and drug delivery strategies​on March 17, 2026 at 6:39 pm

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Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Qamar Abuhassan, Amirali Salajegheh, Faris Anad Muhammad, Ali Fawzi Al-Hussainy, Tushar B. Gajjar, Malathi Hanumanthayya, Sandeep Kumar Shukla, Rajashree Panigrahi, Neeraj Bainsal, Djamila Polatova, Hayder Naji Sameer, Rasim M. Salih, Mohaned Adil  

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