Journal

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of progesterone in human serum and plasmaSara Cheikh Ibrahimon December 1, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 1. doi: 10.1515/cclm-2025-0514. Online ahead of print. ABSTRACT OBJECTIVES: Progesterone regulates reproductive processes and is used clinically to monitor ovarian function in people experiencing fertility problems. Measuring serum progesterone is challenging as it is highly protein-bound and exists at very low physiological levels. An isotope dilution-liquid chromatography-tandem mass spectrometry-based … Read more

Evaluation of the commutability of lombardy region EQA control materials for enzymes, calcium, and creatinine​on November 29, 2025 at 12:40 pm

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Publication date: 30 January 2026 Source: Clinica Chimica Acta, Volume 580 Author(s): Anna Carobene, Matteo Vidali, Ferruccio Ceriotti, Antonella Alberghini, Adele Arcangeli, Walter Bellandi, Paola Cappelletti, Lorenzo Cerutti, Alice Cotellessa, Alberto Dolci, Sara Ena, Stefano Ferrero Bogetto, Cristina Freddi, Antonio Fortunato, Angelo Grassini, Eneida Hoxha, Cristina Kullmann, Massimo Locatelli, Sara Pasqualetti, Andrea Ruvolo  

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of dehydroepiandrosterone sulfate in human serum and plasmaSara Cheikh Ibrahimon November 29, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 1. doi: 10.1515/cclm-2025-0179. Online ahead of print. ABSTRACT OBJECTIVES: Dehydroepiandrosterone sulfate (DHEAS), the sulfate ester of dehydroepiandrosterone, is one of the most common steroid hormones in the human body and the precursor of several other androgens. It is primarily used as a diagnostic or prognostic indicator in adrenal and … Read more

Altered PCSK9 plasma levels after preeclampsia in the PERLA-Brazil study​on November 28, 2025 at 5:41 pm

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Publication date: 30 January 2026 Source: Clinica Chimica Acta, Volume 580 Author(s): Isabella Macedo Costa, Thaíse Emilia Moreira da Silva, Letícia Gonçalves Silva, Ana Paula Silva Ferreira, Thays Santos da Costa, Cláudia Natália Ferreira, Luci Maria Sant’Ana Dusse, Jussara Mayrink, Patrícia Nessralla Alpoim  

From conventional to personalized reference intervals and decision limits: addressing latent errors in the post-post analytical phaseAbdurrahman Coskunon November 27, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 28. doi: 10.1515/cclm-2025-1338. Online ahead of print. ABSTRACT Laboratory errors are an important component of medical errors and are predominantly associated with the extra-analytical phases of the total testing process, particularly the pre-pre-analytical and post-post-analytical phases, which are largely dependent on clinical activities but also require laboratory support. The … Read more

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