A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready?
Clin Chem. 2025 Sep 10:hvaf101. doi: 10.1093/clinchem/hvaf101. Online ahead of print. NO ABSTRACT PMID:40926664 | DOI:10.1093/clinchem/hvaf101
Clinical Chemistry
The Devil Is in the Details: Clinical Relevance of Serologic Antibody Titers to Predict the Diagnosis of Celiac Disease in Pediatric Type 1 Diabetes
Clin Chem. 2025 Sep 3:hvaf102. doi: 10.1093/clinchem/hvaf102. Online ahead of print. NO ABSTRACT PMID:40899701 | DOI:10.1093/clinchem/hvaf102
Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol
Clin Chem. 2025 Sep 3:hvaf099. doi: 10.1093/clinchem/hvaf099. Online ahead of print. ABSTRACT BACKGROUND: Direct measurement of low-density lipoprotein cholesterol (LDL-C) is widely used and recommended by professional society guidelines despite its potential limitations in patients with hypertriglyceridemia and low LDL-C. This study evaluated the performance of 3 direct LDL-C (LDL-CD) assays, 2 modern LDL-C calculation … Read more
Commentary on Complex Hyponatremia in a Cancer Patient with Hypercholesterolemia
Clin Chem. 2025 Sep 3;71(9):933. doi: 10.1093/clinchem/hvaf050. NO ABSTRACT PMID:40898991 | DOI:10.1093/clinchem/hvaf050
Commentary on Complex Hyponatremia in a Cancer Patient with Hypercholesterolemia
Clin Chem. 2025 Sep 3;71(9):934. doi: 10.1093/clinchem/hvaf051. NO ABSTRACT PMID:40898990 | DOI:10.1093/clinchem/hvaf051
A Defining Moment: A Consensus on the Diagnostic Criteria for Clinical Obesity
Clin Chem. 2025 Sep 3;71(9):1009-1010. doi: 10.1093/clinchem/hvaf058. NO ABSTRACT PMID:40898989 | DOI:10.1093/clinchem/hvaf058
Complex Hyponatremia in a Cancer Patient with Hypercholesterolemia
Clin Chem. 2025 Sep 3;71(9):928-932. doi: 10.1093/clinchem/hvaf038. NO ABSTRACT PMID:40898992 | DOI:10.1093/clinchem/hvaf038
Machine Learning Algorithms for Predicting Urinary Tract Infections: Integration of Demographic Data and Dipstick Reflectance Results
Clin Chem. 2025 Aug 26:hvaf088. doi: 10.1093/clinchem/hvaf088. Online ahead of print. ABSTRACT BACKGROUND: Urinary tract infections (UTIs) are among the most common infections encountered in healthcare settings. Current diagnostic practices often require 24-48 h due to the time needed for culture results. Given that 70%-80% of cultures return negative, there is significant interest in rapidly … Read more
In Vitro Metabolic Profiling of 18 Semi-Synthetic Cannabinoids-Hexahydrocannabinol (HHC) and Its Analogs-with Identification in an Authentic Hexahydrocannabiphorol (HHCP) Urine Sample
Clin Chem. 2025 Aug 25:hvaf087. doi: 10.1093/clinchem/hvaf087. Online ahead of print. ABSTRACT BACKGROUND: Hexahydrocannabinol (HHC) and its analogs are recent additions to semi-synthetic cannabinoids in the recreational drug market. Here, the metabolism of 18 HHC analogs was compared to gain a comprehensive understanding of the structure-metabolism relationship of HHC analogs and to identify urinary biomarkers. … Read more
Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use
Clin Chem. 2025 Aug 25:hvaf094. doi: 10.1093/clinchem/hvaf094. Online ahead of print. ABSTRACT BACKGROUND: Protein biomarkers are routinely measured for disease diagnosis and prognosis in clinical laboratories. Since most assays focus on protein quantity, information about proteoforms is often not acquired. Proteoforms of a protein represent the complex integration of genetic polymorphism, alternative splicing of RNA … Read more