Clinical Chemistry

Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis

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Clin Chem. 2025 Jul 18:hvaf074. doi: 10.1093/clinchem/hvaf074. Online ahead of print. ABSTRACT BACKGROUND: Iron deficiency (ID) is a prevalent global health issue with a major impact on well-being. Early detection of ID is crucial but challenging due to its nonspecific symptoms and the limitations of traditional diagnostic tests, which are impractical for large-scale screening. This … Read more

Exploring the Role of Cardiac Troponin-Specific Autoantibodies: Prolonged Cardiac Troponin Elimination, Reduced Clearance, and Variable Interference across 5 Commercial Assays

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Clin Chem. 2025 Jul 15:hvaf077. doi: 10.1093/clinchem/hvaf077. Online ahead of print. ABSTRACT BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) assays are prone to negative and positive interferences caused by endogenous cardiac troponin-specific autoantibodies (cTnAAbs). Large macrotroponin complexes formed of cardiac troponin (cTn) and cTnAAbs may result in falsely elevated hs-cTn results. This is potentially due to reduced … Read more

A Modified Sampson-NIH Equation with Improved Accuracy for Estimating Low Levels of Low-Density Lipoprotein-Cholesterol

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Clin Chem. 2025 Jul 9:hvaf073. doi: 10.1093/clinchem/hvaf073. Online ahead of print. ABSTRACT BACKGROUND: Cardiovascular guidelines have long recommended low-density lipoprotein-cholesterol (LDL-C) as the primary target for lipid-lowering therapy. Recent guidelines have emphasized the importance of achieving low LDL-C levels; hence, the accurate measurement of low LDL-C is increasingly clinically relevant. METHODS: Using lipid panel test … Read more

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