Clinical Chemistry

A Meta-Analysis and Systematic Review of Cardiac Troponin I vs T in Community Dwelling Adults: Is Specificity at Risk?

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Clin Chem. 2025 Mar 27:hvaf023. doi: 10.1093/clinchem/hvaf023. Online ahead of print. ABSTRACT BACKGROUND: Cardiac troponin I and T measured by high-sensitivity assays (hs-cTn) are detectable in most ambulatory adults. Hs-cTnI and T may perform differently for prediction of cardiovascular (CV) events. In adults with myopathies and advanced age, hs-cTnT can lose CV specificity. We undertook … Read more

Placental Biomarker Testing for Evaluation of Suspected Preeclampsia

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Clin Chem. 2025 Mar 25:hvaf024. doi: 10.1093/clinchem/hvaf024. Online ahead of print. ABSTRACT BACKGROUND: Worldwide, hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and neonatal morbidity and mortality (Semin Perinatol 2009;33:130-7). This is especially true in the United States where preeclampsia is a leading cause of premature births (Hypertens Pregnancy 2016;35:510-9 and Lancet … Read more

Determinants of Cardiac Myosin Binding Protein C in the General Population

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Clin Chem. 2025 Mar 20:hvaf013. doi: 10.1093/clinchem/hvaf013. Online ahead of print. ABSTRACT BACKGROUND: Cardiac myosin binding protein C (cMyC) is a novel, cardiac-specific biomarker with an early release profile after acute ischemic myocardial injury. Whether cMyC reflects chronic myocardial injury and left ventricular remodelling in the general population is unknown. The aims of the study … Read more

Carbamylated Albumin, Heart Failure, and Mortality in Patients Undergoing Coronary Angiography

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Clin Chem. 2025 Mar 19:hvaf021. doi: 10.1093/clinchem/hvaf021. Online ahead of print. ABSTRACT BACKGROUND: Urea is elevated in chronic kidney disease (CKD) and end-stage renal disease (ESRD), and promotes the carbamylation of proteins, including human albumin, on multiple lysine side chains. Higher proportions of carbamylated albumin (C-Alb) have been associated with increased mortality risk in patients … Read more

Pediatric Vaccine-Induced Antibody Thresholds: Rethinking Pre-Immunosuppression Serologic Testing and Revaccination Implications

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Clin Chem. 2025 Mar 19:hvaf020. doi: 10.1093/clinchem/hvaf020. Online ahead of print. ABSTRACT BACKGROUND: Immune response to vaccination is assessed when adequate vaccine protection is in question or immunosuppression is imminent through measurement of antibody levels, which wane as time from vaccination increases. The serologic cutoff value for adequate response is based on thresholds derived from … Read more

Cardiac Troponin I and T Ratio and Risk of Cardiovascular or Non-Cardiovascular Events in a General Population

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Clin Chem. 2025 Feb 19:hvaf016. doi: 10.1093/clinchem/hvaf016. Online ahead of print. ABSTRACT BACKGROUND: Emerging evidence suggests that the ratio between cardiac troponin (cTn) I and T may provide information on the risk of adverse outcomes in individuals with cardiovascular disease. Whether the cTn I/T ratio provides prognostic insights in the general population is unknown. METHODS: … Read more

Direct-to-Consumer Testing: Benefits and Concerns of Commercially Accessed Laboratory Tests

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Clin Chem. 2025 Feb 18:hvaf004. doi: 10.1093/clinchem/hvaf004. Online ahead of print. ABSTRACT BACKGROUND: Promoting self-empowerment of patients and of healthy persons in contemporary health cultures shifts the imperative for initiating laboratory tests from the healthcare professionals (HCP) to the patients themselves. CONTENT: Laboratory testing requested directly by patients without interaction by HCP is called DTCT … Read more

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