Clinical Chemistry and Laboratory Medicine

Targeted proteomics of serum IGF-I, -II, IGFBP-2, -3, -4, -5, -6 and ALSJakob Albrethsenon March 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 24. doi: 10.1515/cclm-2024-1428. Online ahead of print. ABSTRACT OBJECTIVES: The insulin-like growth factors (IGFs) regulate growth in humans. IGF-I and IGF binding protein (IGFBP)-3 are biomarkers in children with growth disorders. We investigate a targeted proteomics method for absolute quantitation of eight IGF protein family members in human serum, … Read more

Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?Claudia Grossion March 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 21. doi: 10.1515/cclm-2025-0032. Online ahead of print. ABSTRACT OBJECTIVES: The Certified Reference Material (CRM) ERM®-DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated CRM’s ability to represent the heterogeneity of APS patient anti-β2GPI antibodies and … Read more

Reliable detection of sex chromosome abnormalities by quantitative fluorescence polymerase chain reactionCamilla Mains Balleon March 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1400. Online ahead of print. ABSTRACT OBJECTIVES: Many patients with sex chromosome abnormalities (SCAs) are diagnosed late in life or remain undiagnosed, leading to delayed or inadequate medical intervention and care. This study aimed to develop a reliable, rapid and cost-effective test for identifying SCAs using a … Read more

Use of the BIOGROUP® French laboratories database to conduct CKD observational studies: a pilot EPI-CKD1 studyClaire Visseauxon March 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1399. Online ahead of print. ABSTRACT OBJECTIVES: Medical biology is essential for diagnosing and monitoring cardio-reno-metabolic diseases. The EPI-CKD1 study utilizes data from Biogroup® French laboratories to examine the burden of chronic kidney disease (CKD) and the effect of heart failure, and diabetes in an outpatient setting … Read more

Novel protocol for metabolomics data normalization and biomarker discovery in human tearsJoan Serrano-Marínon March 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 19. doi: 10.1515/cclm-2024-1360. Online ahead of print. ABSTRACT OBJECTIVES: Human tear analysis holds promise for biomarker discovery, but its clinical utility is hindered by the lack of standardized reference values, limiting interindividual comparisons. This study aimed at developing a protocol for normalizing metabolomic data from human tears, enhancing its … Read more

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