Clinical Chemistry and Laboratory Medicine

Thresholds adjustments and impact on clinical performance of three FIT assays in a colorectal cancer screening programJean Dubéon November 9, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0546. Online ahead of print. ABSTRACT OBJECTIVES: Fecal immunochemical tests (FITs) from various manufacturers yield different results, leading to variable positivity rates and clinical performance. These differences can influence the healthcare costs of a colorectal cancer screening program (CRC-SP), specifically when switching among FIT manufacturers. The analytical … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid glucuronide in human serum and plasmaTobias Schierscheron November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1052. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid glucuronide (MPAG). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was … Read more

Pro-gastrin releasing peptide as a tumor marker of medullary thyroid carcinoma: a comparative bivariate meta-analysisPetra Petranović Ovčaričekon November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0867. Online ahead of print. ABSTRACT OBJECTIVES: Calcitonin (CT) is the established biomarker for medullary thyroid carcinoma (MTC), but its measurement is hampered by analytical limitations. Procalcitonin (PCT) and pro-gastrin-releasing peptide (ProGRP) have been proposed as alternative or complementary markers, yet the diagnostic value of ProGRP remains … Read more

Reimagining External Quality Assessment for precision medicine: a perspective from biochemistry laboratoriesStanford Chigaroon November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1240. Online ahead of print. ABSTRACT External Quality Assessment (EQA) is central to quality assurance in laboratory medicine, providing independent measures of tests trueness, and inter-laboratory comparability. Traditional EQA schemes, designed around stable and well-characterised measurands, have been successful in routine analytes such as electrolytes and liver … Read more

Spot urine is a suitable matrix for measurement of copeptinJulie Sherfanon November 4, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 5. doi: 10.1515/cclm-2025-1055. Online ahead of print. ABSTRACT OBJECTIVES: To validate urine as a suitable matrix for copeptin measurements, derive a urinary copeptin/creatinine ratio in an apparently healthy sample of the population, and assess pre-analytical conditions such as collection type and storage temperatures that affect stability and recovery. METHODS: … Read more

Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish society of laboratory medicine and the Spanish society of hematology and hemotherapy. Part III: clinical and analytical recommendations for the study of monoclonal gammopathies by MALDI-TOF mass spectrometryCristina Agullóon November 3, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 4. doi: 10.1515/cclm-2025-1056. Online ahead of print. ABSTRACT Monoclonal gammopathies (MGs) represent a diverse group of plasma cell disorders that range from asymptomatic premalignant conditions to aggressive malignancies such as multiple myeloma (MM). Mass spectrometry (MS) based serum analysis offers a non-invasive, highly sensitive alternative to conventional techniques for … Read more

An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of total and free valproic acid in human serum and plasmaTobias Schierscheron November 3, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 4. doi: 10.1515/cclm-2025-1053. Online ahead of print. ABSTRACT OBJECTIVES: An isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (cRMP) was developed and validated to measure serum and plasma concentrations of the total and free form of valproic acid. METHODS: Quantitative nuclear magnetic resonance spectroscopic methodology was … Read more

Creatinine measurement from finger stick dried blood spots with a routine chemistry analyzer for estimation of GFRJ Corné van Damon November 3, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 3. doi: 10.1515/cclm-2025-0979. Online ahead of print. ABSTRACT OBJECTIVES: Measuring creatinine levels is essential for assessing kidney function. However, traditional venous sampling poses challenges in terms of sample collection, storage, and transportation. Recently, dried blood spot (DBS) analysis has emerged as a potential alternative for measuring creatinine levels, although … Read more

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