Clinical Chemistry and Laboratory Medicine

Staining and serological characteristics of the AC-30 pattern in HEp-2 IIFA: a comparative study with AC-2 patternChuiwen Dengon September 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 25. doi: 10.1515/cclm-2025-0817. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the staining and serological characteristics of AC-30 pattern. METHODS: A total of 184 participants were recruited from patients who underwent routine antinuclear antibody testing between 2022 and 2023 at Peking Union Medical College Hospital. Cohort 1 (n=47) showed … Read more

Establishing reference intervals for high-sensitivity cardiac troponin T in neonates and infantsYue-Qi Lion September 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 25. doi: 10.1515/cclm-2025-0985. Online ahead of print. ABSTRACT OBJECTIVES: High-sensitivity cardiac troponin T (hs-cTnT) is used in pediatric healthcare to diagnose and assess the prognosis of various cardiac diseases, such as acute myocarditis, congenital heart disease, dilated cardiomyopathy, and heart failure. However, the standardized age-related reference intervals, 99th percentile … Read more

Moving to practice with the application of Milan model 1b-based analytical performance specificationsMauro Panteghinion September 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 25. doi: 10.1515/cclm-2025-1014. Online ahead of print. ABSTRACT The definition of analytical performance specifications (APS) by the Milan model 1b is based on indirect approaches investigating the impact of analytical performance of the laboratory test on clinical classification and thereby on the probability of patient outcomes. As direct diagnostic … Read more

Supporting trend detection in the cumulative display of electronic laboratory reports from multiple laboratories while preserving measurement provenanceAndreas Bietenbeckon September 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 25. doi: 10.1515/cclm-2025-1160. Online ahead of print. ABSTRACT Electronic health records will increasingly aggregate longitudinal laboratory results from multiple providers, but availability alone does not guarantee safe interpretation. We present guidance, developed by laboratory professionals with the DGKL medical informatics division, for cumulative displays that are clinically meaningful. The … Read more

Does patient-based data monitoring allow us to reconsider the relationship between IQC and EQA?Tony Badrickon September 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 24. doi: 10.1515/cclm-2025-1133. Online ahead of print. ABSTRACT Currently, there is no accepted standard practice for determining the frequency of EQA challenge. The challenge frequency has evolved based on history and local requirements. However, EQA frequency should be based on identifying patient risks caused by poorly performing laboratories, methods, … Read more

Comparative analysis of ISO 15189:2022 with earlier versions with reference to ethicsSudip K Dattaon September 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 24. doi: 10.1515/cclm-2025-0884. Online ahead of print. ABSTRACT OBJECTIVES: The International Organisation for Standardisation (ISO) 15189 standard provides the requirements for quality and competence in medical laboratories. It aims to ensure that laboratories deliver accurate and reliable results for patient care. The first version of the same was published … Read more

EQALM recommendations for the analytical performance specifications for blood smear interpretation in haematology: a need for standardizationStéphanie Albarèdeon September 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 24. doi: 10.1515/cclm-2025-1011. Online ahead of print. ABSTRACT OBJECTIVES: The European Organization for External Quality Assurance Providers in Laboratory Medicine (EQALM) Haematology Working Group (WG) has previously provided two guidelines to support the standardization of haematology blood smear external quality assessment (EQA) (Vives CJL, Albarède S, Flandrin G, Heller … Read more

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