Clinical Chemistry and Laboratory Medicine

Direct screening and quantification of monoclonal immunoglobulins in serum using MALDI-TOF mass spectrometry without antibody enrichmentHou-Long Luoon April 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 18. doi: 10.1515/cclm-2025-0203. Online ahead of print. ABSTRACT OBJECTIVES: Monoclonal gammopathies (MGs) are characterized by the presence of monoclonal immunoglobulins (M-proteins). Currently, recommendations for screening of MGs primarily rely on nephelometry, turbidimetry and electrophoresis, which have inherent limitations in sensitivity and throughput. This study aimed to evaluate a novel … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisone in human serum and plasmaMyriam Otton April 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 17. doi: 10.1515/cclm-2024-1478. Online ahead of print. ABSTRACT OBJECTIVES: Cortisone is an inert precursor/metabolite of the potent steroid hormone cortisol. Measurement of serum cortisone levels and the cortisol-cortisone ratio can be useful for the diagnosis of dysfunction in the regulation of cortisol levels (i.e., severe and subtle apparent mineralocorticoid … Read more

Evaluation of sex-specific 0-h high-sensitivity cardiac troponin T thresholds for the risk stratification of non-ST-segment elevation myocardial infarctionAilun Zhangon April 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 17. doi: 10.1515/cclm-2024-1118. Online ahead of print. ABSTRACT OBJECTIVES: We aimed to evaluate sex-specific 0-h high-sensitivity cardiac troponin T (hs-cTnT) thresholds for risk stratification in patients with suspected non-ST-segment elevation myocardial infarction (NSTEMI). METHODS: This retrospective study investigated a derivation cohort of 6,691 (44.4 % female and aged 65 … Read more

Digital metrology in laboratory medicine: a call for bringing order to chaos to facilitate precision diagnosticsMadeleen Bosmaon April 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 16. doi: 10.1515/cclm-2025-0152. Online ahead of print. ABSTRACT Laboratory medicine is faced with rapid developments in data exchange, secondary use of data and artificial intelligence. Safe exchange of laboratory data requires a suitable terminology standard. NPU, LOINC and SNOMED CT are increasingly used for this purpose, but none of … Read more

Assessment of serum free light chain measurements in a large Chinese chronic kidney disease cohort: a multicenter real-world studyXia Luoon April 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2024-1226. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing monoclonal gammopathy in chronic kidney disease (CKD) patients is challenging due to the complex interpretation of serum free light chain (FLC) levels. This study aimed to assess the FLC levels in a large cohort of Chinese CKD patients. METHODS: … Read more

Defining dried blood spot diameter: implications for measurement and specimen rejection ratesNick Flynnon April 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2025-0183. Online ahead of print. ABSTRACT OBJECTIVES: Dried blood spot (DBS) specimen acceptance guidelines recommend rejecting specimens based on DBS size, often expressed as a diameter. Computer vision methods can estimate DBS size from images obtained from standalone equipment, smartphone cameras or existing laboratory instrumentation. However, no … Read more

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