Clin Chem Lab Med. 2025 Oct 15. doi: 10.1515/cclm-2025-0761. Online ahead of print. NO ABSTRACT PMID:41084761 | DOI:10.1515/cclm-2025-0761
Clin Chem Lab Med. 2025 Oct 9. doi: 10.1515/cclm-2025-1129. Online ahead of print. ABSTRACT OBJECTIVES: To compare the diagnostic performances of GFAP and UCH-L1 with S100B in detecting intracranial injury, while investigating the impact of confounding factors. METHODS: In a large prospective cohort of 1,010 patients with mild traumatic brain injury, we first evaluated the … Read more
Clin Chem Lab Med. 2025 Oct 7. doi: 10.1515/cclm-2025-1030. Online ahead of print. ABSTRACT OBJECTIVES: Detection of paraneoplastic anti-neuronal antibodies (PNS autoantibodies) aids in diagnosing the particular syndrome and guides the search for an underlying tumor. To identify opportunities for harmonization that could enhance diagnostic value, we assessed variability in autoimmune serological testing for PNS … Read more
Clin Chem Lab Med. 2025 Oct 7. doi: 10.1515/cclm-2025-1162. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratory operations consume large amounts of electricity and water and generate considerable quantities of solid waste. In this study, we quantified and compared the estimated solid waste produced from performing one million basic metabolic panels (BMPs) across five major … Read more
Clin Chem Lab Med. 2025 Oct 3. doi: 10.1515/cclm-2025-0582. Online ahead of print. ABSTRACT OBJECTIVES: Neuron-specific enolase (NSE) is a clinically relevant biomarker used in the assessment of neuronal damage and in the diagnosis and monitoring of certain cancers. Despite its diagnostic importance, paediatric-specific reference intervals (RIs) for NSE are currently lacking. This study aimed … Read more
Clin Chem Lab Med. 2025 Oct 2. doi: 10.1515/cclm-2025-1136. Online ahead of print. ABSTRACT OBJECTIVES: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is increasingly used in clinical laboratories due to its high analytical specificity and multiplexing capabilities. While the pre-analytical and analytical phases have seen significant advances in automation, the post-analytical phase remains a bottleneck with limited … Read more
Clin Chem Lab Med. 2025 Jun 24;63(11):2330-2340. doi: 10.1515/cclm-2025-0045. Print 2025 Oct 27. ABSTRACT OBJECTIVES: Glycosylation is a tightly controlled co-translational and post-translational enzymatic modification. Total N-glycome profiling in blood serum/plasma provides information on the most common serum/plasma glycosylation. Total plasma N-glycome from various population samples displayed predictive ability for type 2 diabetes incidence in … Read more
Clin Chem Lab Med. 2025 Oct 1. doi: 10.1515/cclm-2025-0941. Online ahead of print. ABSTRACT EU laws are usually evaluated after 10 years; in the case of the IVDR, the targeted evaluation was brought forward and stakeholders in laboratory diagnostics were invited to comment. The Association of the Scientific Medical Societies in Germany (AWMF; Arbeitsgemeinschaft der … Read more
Clin Chem Lab Med. 2025 Sep 29. doi: 10.1515/cclm-2025-0581. Online ahead of print. ABSTRACT OBJECTIVES: Regulatory guidelines recommend non-parametric Passing-Bablok regression for evaluating the agreement between two measurement methods in laboratory settings. However, concluding for the agreement if the 95 % CI of the slope and of the intercept include 1 and 0, respectively is … Read more
Clin Chem Lab Med. 2025 Sep 29. doi: 10.1515/cclm-2025-0461. Online ahead of print. ABSTRACT New technologies and advances in human biology are paving the way for better patient management and outcomes in laboratory medicine. Precision diagnostics, as an essential component of P5 medicine, implies a shift towards selective testing of defined measurands, enabling a higher … Read more
