Advanced Laboratory Medicine

Adv Lab Med. 2026 Mar 16;7(2):90-104. doi: 10.1515/almed-2025-0169. eCollection 2026 Jun. ABSTRACT Carcinocythemia, or carcinoma cell leukemia, is a rare but striking manifestation of advanced malignancy in which circulating tumor cells (CTCs) are visible in peripheral blood (PB) smears using conventional staining. It is typically associated with advanced stage disease and poor prognosis. This review … Read more

Adv Lab Med. 2026 Apr 23;7(2):124-131. doi: 10.1515/almed-2025-0180. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease of immune-mediated origin. Janus kinase inhibitors (JAK inhibitors) have expanded therapeutic options in recent years; however, clinical response varies among patients, and no biomarkers are currently available to predict their efficacy. The aim of … Read more

Adv Lab Med. 2026 Apr 28;7(2):132-139. doi: 10.1515/almed-2026-0007. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Gestational diabetes mellitus (GDM) and thyroid dysfunction are two common endocrine diseases during pregnancy, both of which can adversely affect maternal and fetal health. Numerous studies have shown that abnormalities in thyroid hormones, particularly TSH and FT4, are associated with an increased … Read more

Adv Lab Med. 2026 Apr 15;7(2):140-147. doi: 10.1515/almed-2025-0053. eCollection 2026 Jun. ABSTRACT OBJECTIVES: There is apprehension regarding the agreement between capillary and venous hemoglobin (Hb) concentrations, which may have far-reaching consequences for global anemia prevalence estimates, heavily dependent on capillary Hb data. METHODS: We investigated the discrepancies in Hb concentrations obtained from venous and capillary … Read more

Adv Lab Med. 2026 Apr 7;7(2):105-115. doi: 10.1515/almed-2025-0175. eCollection 2026 Jun. ABSTRACT OBJECTIVES: The objectives of this study included assessing the diagnostic performance of HE4 in malignant pleural effusions (MPEs) and identifying the benign etiologies associated with higher HE4 concentrations. METHODS: The study involved patients with pleural effusion (PE) treated at Part Taulí University Hospital. … Read more

Adv Lab Med. 2025 Sep 1;7(1):10-15. doi: 10.1515/almed-2025-0121. eCollection 2026 Mar. ABSTRACT For centuries, the only ‘semeiological and laboratory’ test that the physician had at his disposal to point towards to a diagnosis was the urine test. It was based on the chemical and physical properties evaluation of the sample. During the last decade of … Read more

Adv Lab Med. 2025 Dec 8;7(1):52-58. doi: 10.1515/almed-2025-0087. eCollection 2026 Mar. ABSTRACT OBJECTIVES: To evaluate the feasibility of urinary DNA as a noninvasive alternative for high-resolution HLA genotyping and validate its concordance with conventional blood-based methods. METHODS: Matched urine and blood samples were collected from 11 healthy volunteers. Urinary DNA was extracted using an optimized … Read more

Adv Lab Med. 2025 Nov 24;7(1):59-63. doi: 10.1515/almed-2025-0133. eCollection 2026 Mar. ABSTRACT OBJECTIVES: To evaluate the analytical performance of platelet counts obtained by impedance- and optical-based methods on the DxH-900 and BC-6800 Plus analyzers, and by digital morphology using the CellaVision DM9600, in comparison with the international reference method (IRM), in samples with thrombocytopenia and … Read more

Adv Lab Med. 2025 Oct 3;7(1):68-73. doi: 10.1515/almed-2025-0107. eCollection 2026 Mar. ABSTRACT OBJECTIVES: Primary cardiac lymphoma represents an extremely rare entity of extranodal non-Hodgkin lymphoma. CASE PRESENTATION: We report the case of a woman who presented with dyspnea, asthenia, chest pain, cough, and odynophagia. Investigations revealed a diffuse large B-cell lymphomas type primary cardiac lymphoma … Read more

Adv Lab Med. 2026 Jan 15;7(1):43-51. doi: 10.1515/almed-2025-0144. eCollection 2026 Mar. ABSTRACT OBJECTIVES: Alpha-fetoprotein L3 (AFP-L3 %) and protein induced by vitamin K absence-II (PIVKA-II) are used in diagnostic scores such as GAAD, GALAD, and ASAP for hepatocellular carcinoma (HCC) detection. Advanced liver fibrosis (ALF) is diagnosable by the liver fibrosis index and could be … Read more