Advanced Laboratory Medicine

Adv Lab Med. 2026 Jan 22;7(2):153-155. doi: 10.1515/almed-2025-0161. eCollection 2026 Jun. ABSTRACT OBJECTIVES: This study evaluates the efficacy of the icteric index as a pre-screening tool for hyperbilirubinemia in adult patients. METHODS: The use of this index would help optimize the use of clinical laboratory resources. RESULTS: A retrospective analysis of 3,194 serum samples revealed … Read more

Adv Lab Med. 2026 Jan 12;7(2):160-162. doi: 10.1515/almed-2025-0099. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Pulmonary-renal syndrome (PRS) is a serious condition characterized by concurrent alveolar hemorrhage and rapidly progressive glomerulonephritis. One of the potential causes of PRS is the presence of anti-glomerular basement membrane (anti-GBM) antibodies, which may induce Goodpasture syndrome, a rare, albeit life-threatening, condition … Read more

Adv Lab Med. 2025 Nov 25;7(2):156-159. doi: 10.1515/almed-2025-0148. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Troponins are a complex of three proteins that play a key role in the contraction of striated muscles. Currently, cardiac troponins T (cTnT) and I (cTnI) are the best biomarkers for acute myocardial infarction (AMI) diagnostic. CASE PRESENTATION: Immune-mediated toxicity due to … Read more

Adv Lab Med. 2026 Jan 28;7(2):81-89. doi: 10.1515/almed-2025-0187. eCollection 2026 Jun. ABSTRACT Prostate-specific antigen (PSA) is a widely available and analytically robust biomarker, but its role in prostate cancer (PCa) screening remains controversial due to concerns regarding limited specificity, overdiagnosis of indolent tumors, and the downstream risk of overtreatment. This review provides a critical analysis … Read more

Adv Lab Med. 2025 Dec 8;7(2):148-152. doi: 10.1515/almed-2025-0098. eCollection 2026 Jun. ABSTRACT OBJECTIVES: We aimed to develop a simple, cost-effective algorithm to predict the presence of oligoclonal IgM bands (OCMB) in patients with multiple sclerosis (MS), using surrogate markers such as the IgM Index (IgMi) and the Free Kappa Light Chains Index (FKLCi), with the … Read more

Adv Lab Med. 2026 Mar 16;7(2):90-104. doi: 10.1515/almed-2025-0169. eCollection 2026 Jun. ABSTRACT Carcinocythemia, or carcinoma cell leukemia, is a rare but striking manifestation of advanced malignancy in which circulating tumor cells (CTCs) are visible in peripheral blood (PB) smears using conventional staining. It is typically associated with advanced stage disease and poor prognosis. This review … Read more

Adv Lab Med. 2026 Apr 23;7(2):124-131. doi: 10.1515/almed-2025-0180. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease of immune-mediated origin. Janus kinase inhibitors (JAK inhibitors) have expanded therapeutic options in recent years; however, clinical response varies among patients, and no biomarkers are currently available to predict their efficacy. The aim of … Read more

Adv Lab Med. 2026 Apr 28;7(2):132-139. doi: 10.1515/almed-2026-0007. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Gestational diabetes mellitus (GDM) and thyroid dysfunction are two common endocrine diseases during pregnancy, both of which can adversely affect maternal and fetal health. Numerous studies have shown that abnormalities in thyroid hormones, particularly TSH and FT4, are associated with an increased … Read more

Adv Lab Med. 2026 Apr 15;7(2):140-147. doi: 10.1515/almed-2025-0053. eCollection 2026 Jun. ABSTRACT OBJECTIVES: There is apprehension regarding the agreement between capillary and venous hemoglobin (Hb) concentrations, which may have far-reaching consequences for global anemia prevalence estimates, heavily dependent on capillary Hb data. METHODS: We investigated the discrepancies in Hb concentrations obtained from venous and capillary … Read more

Adv Lab Med. 2026 Apr 7;7(2):105-115. doi: 10.1515/almed-2025-0175. eCollection 2026 Jun. ABSTRACT OBJECTIVES: The objectives of this study included assessing the diagnostic performance of HE4 in malignant pleural effusions (MPEs) and identifying the benign etiologies associated with higher HE4 concentrations. METHODS: The study involved patients with pleural effusion (PE) treated at Part Taulí University Hospital. … Read more