Advanced Laboratory Medicine

Re-evaluating haemolysis rejection criteria for PT, aPTT, and D-dimer testing: evidence from paired clinical samples on the CN-3000 analyser​Jirapa Kaewkhruawanon September 9, 2026 at 10:00 am

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Adv Lab Med. 2026 May 14;7(3):179-186. doi: 10.1515/almed-2026-0028. eCollection 2026 Sep. ABSTRACT OBJECTIVES: Haemolysis is the leading preanalytical cause of sample rejection in coagulation testing. This study prospectively evaluated the impact of spontaneous haemolysis on routine haemostasis assays by comparing paired haemolysed (H) and non-haemolysed (NH) clinical samples. Additionally, analyser flagging behaviour was characterised using … Read more

When rare diseases do not appear as a single entity​Isabel Solareson September 9, 2026 at 10:00 am

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Adv Lab Med. 2026 Jul 16;7(3):234-237. doi: 10.1515/almed-2025-0193. eCollection 2026 Sep. ABSTRACT OBJECTIVES: The coexistence of multisystemic involvement in a young adult raises the need to consider rare metabolic and mitochondrial disorders. We report a case of late-onset propionic acidemia (PPA) that may have contributed to unmasking Leber hereditary optic neuropathy (LHON), an extremely infrequent … Read more

Appearances can be deceptive: acute myeloid leukaemia simulating chronic lymphocytic leukaemia​Beatriz Gómez Horsefieldon September 9, 2026 at 10:00 am

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Adv Lab Med. 2026 May 20;7(3):229-233. doi: 10.1515/almed-2025-0184. eCollection 2026 Sep. ABSTRACT OBJECTIVES: To report a rare case of acute myeloid leukemia (AML) with abnormal chromatin clumping (ACC) in myeloblasts mimicking chronic lymphocytic leukemia (CLL), highlighting the associated diagnostic challenges. CASE PRESENTATION: An 82-year-old woman presented with fatigue, weight loss, and pancytopenia. Peripheral blood film … Read more

Evaluation of LN34 real-time PCR assay for detection of rabies virus in human and animal specimens​Lonika Lodhaon September 9, 2026 at 10:00 am

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Adv Lab Med. 2026 Jul 7;7(3):222-228. doi: 10.1515/almed-2025-0197. eCollection 2026 Sep. ABSTRACT OBJECTIVES: Rabies, a neglected zoonotic encephalitis caused by lyssaviruses, claims around 59,000 lives annually. PCR-based methods are pivotal for laboratory confirmation of rabies in humans and animals. The LN34 pan-lyssavirus real time PCR assay has demonstrated good diagnostic performance in detecting rabies viral … Read more

Utility of the I-index as a pre-screening tool for total bilirubin testing: a retrospective study in a regional hospital​Amanda Jiménez Garcíaon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Jan 22;7(2):153-155. doi: 10.1515/almed-2025-0161. eCollection 2026 Jun. ABSTRACT OBJECTIVES: This study evaluates the efficacy of the icteric index as a pre-screening tool for hyperbilirubinemia in adult patients. METHODS: The use of this index would help optimize the use of clinical laboratory resources. RESULTS: A retrospective analysis of 3,194 serum samples revealed … Read more

Anti-GBM pulmonary-renal syndrome: when the laboratory makes the difference​Carmen Frías Ruizon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Jan 12;7(2):160-162. doi: 10.1515/almed-2025-0099. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Pulmonary-renal syndrome (PRS) is a serious condition characterized by concurrent alveolar hemorrhage and rapidly progressive glomerulonephritis. One of the potential causes of PRS is the presence of anti-glomerular basement membrane (anti-GBM) antibodies, which may induce Goodpasture syndrome, a rare, albeit life-threatening, condition … Read more

High sensitive troponin T elevation in an oncology patient on treatment with Pembrolizumab​Alberto Alcalde Moraleson May 15, 2026 at 10:00 am

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Adv Lab Med. 2025 Nov 25;7(2):156-159. doi: 10.1515/almed-2025-0148. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Troponins are a complex of three proteins that play a key role in the contraction of striated muscles. Currently, cardiac troponins T (cTnT) and I (cTnI) are the best biomarkers for acute myocardial infarction (AMI) diagnostic. CASE PRESENTATION: Immune-mediated toxicity due to … Read more

The evolving role of PSA in prostate cancer screening: revisiting the evidence in the era of personalized medicine​Xavier Filellaon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Jan 28;7(2):81-89. doi: 10.1515/almed-2025-0187. eCollection 2026 Jun. ABSTRACT Prostate-specific antigen (PSA) is a widely available and analytically robust biomarker, but its role in prostate cancer (PCa) screening remains controversial due to concerns regarding limited specificity, overdiagnosis of indolent tumors, and the downstream risk of overtreatment. This review provides a critical analysis … Read more

An algorithm to predict intrathecal IgM synthesis in multiple sclerosis patients: optimizing the use of oligoclonal band testing​Jordi Tortosa-Carrereson May 15, 2026 at 10:00 am

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Adv Lab Med. 2025 Dec 8;7(2):148-152. doi: 10.1515/almed-2025-0098. eCollection 2026 Jun. ABSTRACT OBJECTIVES: We aimed to develop a simple, cost-effective algorithm to predict the presence of oligoclonal IgM bands (OCMB) in patients with multiple sclerosis (MS), using surrogate markers such as the IgM Index (IgMi) and the Free Kappa Light Chains Index (FKLCi), with the … Read more

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