ccinfoadmin

A cost-effective assessment for the combination of indirect immunofluorescence and solid-phase assay in ANA-screeningNicoletta Galloon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0170. Online ahead of print. ABSTRACT OBJECTIVES: Anti-nuclear antibodies (ANA) testing on indirect immunofluorescence (IIF) has been for a long time the gold standard assay in the diagnosis of rheumatic diseases; more recently different solid phase assays (SPA) have been recommended to increase specificity of positive results. … Read more

Vitamin D metabolome in preterm infants: insights into postnatal metabolismTomas Matejekon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0311. Online ahead of print. ABSTRACT OBJECTIVES: To describe the structure of vitamin D metabolome and investigate the possible cause of high serum levels of C3 epimers of 25-(OH)D in preterm infants, we compared the vitamin D metabolites in umbilical cord blood with serum samples taken at … Read more

Recommendations for the integration of standardized quality indicators for glucose point-of-care testingJulie L V Shawon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0448. Online ahead of print. ABSTRACT OBJECTIVES: Quality indicator (QI) monitoring is essential to quality assurance for point of care testing (POCT). QI standardization is needed in the POCT field to provide clear guidance to hospitals and produce National and International benchmarks. A central aim was to … Read more

Improving Transfusion Practices for Pediatric Patients​on May 9, 2025 at 4:00 am

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Yale Laboratory Medicine faculty, including Drs. Jeanne Hendrickson, George Hauser, Thomas Binns and Nalan Yurtsever, attended the Domestic Steering Committee meeting for REDS-IV-P held April 29th-May 1st in Bethesda, MD. Yale is one of four hubs involved in REDS, a multisite project aiming to improve transfusion practices in the pediatric population. REDS-IV-P stands for Recipient … Read more

The Departments of Laboratory Medicine and Pathology now rank sixth in total NIH funding in the nation for our discipline.​on May 2, 2025 at 4:00 am

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The Departments of Laboratory Medicine and Pathology now rank sixth in total NIH funding in the nation for our discipline. The work of our faculty and trainees covers the full spectrum of research with particular strength in immunology, cancer biology, infectious diseases, computational health care, genomics, stem cell biology, neurosciences, diagnostics, and translational research. Yale … Read more

Full-Length Clonal Immunoglobulin Rearrangements in cfDNA: Improved Recovery and Sequencing

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Clin Chem. 2025 May 26:hvaf064. doi: 10.1093/clinchem/hvaf064. Online ahead of print. ABSTRACT BACKGROUND: Circulating tumor DNA present in cell-free DNA (cfDNA) serves as diagnostic, predictive, and prognostic markers in cancer patients. In lymphoma patients, clonal immunoglobulin (cIg) sequences enable accurate identification of disease states. Despite its importance, there is sparse literature surrounding the preanalytical and … Read more

Challenges in Hb A1c Point-of-Care Testing: Only 6 of 19 Hb A1c Point-of-Care Devices Meet IFCC and NGSP Certification Criteria on Independent Evaluation

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Clin Chem. 2025 May 26:hvaf059. doi: 10.1093/clinchem/hvaf059. Online ahead of print. ABSTRACT BACKGROUND: Access to Hb A1c testing in low- and middle-income countries (LMICs) can be limited, especially in rural areas. This has led to an increased interest in the potential role of point-of-care testing (POCT) for Hb A1c. The analytical performance of many of … Read more

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