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An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 17β-estradiol in human serum and plasmaMyriam Otton May 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 26. doi: 10.1515/cclm-2024-1255. Online ahead of print. ABSTRACT OBJECTIVES: A new candidate isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based reference measurement procedure (RMP) has been developed for the accurate and precise quantification of 17β-estradiol (E2) in human serum and plasma covering a measurement range from 0.400 to 5,000 pg/mL (1.47-18,357 … Read more

Diagnosis of Drug-Resistant Tuberculosis: Rapid Evaluation of Drug Susceptibility with Nanopore Targeted Sequencing

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Clin Chem. 2025 May 27:hvaf061. doi: 10.1093/clinchem/hvaf061. Online ahead of print. ABSTRACT BACKGROUND: Whole-genome sequencing (WGS) has limitations in clinical diagnostics due to host DNA interference and lower pathogen load in clinical samples compared to cultured isolates, which reduce the effective sequencing depth and compromise the detection of resistance-associated mutations. As our understanding of the … Read more

Candidate reference measurement procedure based on isotope dilution-two dimensional-liquid chromatography-tandem mass spectrometry for the quantification of androstenedione in human serum and plasmaMyriam Otton May 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 23. doi: 10.1515/cclm-2024-1135. Online ahead of print. ABSTRACT OBJECTIVES: Androstenedione (ASD) is a biomarker used in the diagnosis of hyperandrogenism and adrenal hyperplasia. Therefore, accurate measurement of serum ASD is pivotal in clinical settings. We aimed to develop a novel highly selective reference measurement procedure (RMP) based on isotope … Read more

Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approachAbdulrazzaq Alherakyon May 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0189. Online ahead of print. ABSTRACT OBJECTIVES: Histamine, mainly produced in mast cells (MC), plays a key role in allergy and inflammation. Measuring its urinary metabolites, N-methylhistamine (NMH) and 1-methyl-4-imidazoleacetic acid (MIMA), is essential in assessing histamine-related pathologies. Patients with concurrent systemic mastocytosis (SM) and hereditary alpha … Read more

High myoglobin plasma samples risk being reported as falsely low due to antigen excess – follow up after a 2-year period of using a mitigating procedureAnders O Olssonon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0409. Online ahead of print. ABSTRACT OBJECTIVES: Antigen excess (AE) or high dose hook-effect can seriously affect the reported concentration of an analyte, which may impact clinical decisions. This study analyze to what extent the Roche Elecsys® Myoglobin assay is affected by antigen excess and how this … Read more

Practical handling of hemolytic, icteric and lipemic samples for coagulation testing in European laboratories. A collaborative survey from the European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM)Ann Helen Kristoffersenon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0319. Online ahead of print. ABSTRACT OBJECTIVES: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for HIL-management are missing, both for manual and automatic HIL-checks. The aim of this survey was to provide an overview of the practical procedures for the … Read more

Diagnostic performance of morphological analysis and red blood cell parameter-based algorithms in the routine laboratory screening of heterozygous haemoglobinopathiesGermain Simonon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0210. Online ahead of print. ABSTRACT OBJECTIVES: The aim of this study was to carry out a cross-analysis of the morphological abnormalities (MA) and the electrophoretic profile (EP) of blood samples suspect for heterozygous haemoglobinopathies (HTZ HGP). Screening for HTZ HGP was based on erythrocyte parameters provided … Read more

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