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Utilization analysis of laboratory tests using health insurance claims data: advancing nationwide diagnostic stewardship monitoring systemsSe-Eun Kooon July 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 15. doi: 10.1515/cclm-2025-0641. Online ahead of print. ABSTRACT OBJECTIVES: Diagnostic stewardship aims to optimize laboratory testing practices by ensuring appropriate test utilization while minimizing unnecessary testing. However, the nationwide monitoring systems for laboratory test utilization remain underdeveloped. In this study, we analyzed nationwide health insurance claims data to identify … Read more

What matters most: an age-friendly approach to pathology and laboratory medicineMelody Boudreaux Nelsonon July 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 14. doi: 10.1515/cclm-2025-0616. Online ahead of print. ABSTRACT Under the Age-Friendly Health System initiative, “What Matters” is defined as knowing the older adult’s specific health outcome goals and care preferences. This involves multiple settings of care (e.g., hospital, skilled nursing facility, outpatient visits) and can include end-of-life care. However, … Read more

Assessment of 2023 ACR/EULAR antiphospholipid syndrome classification criteria in a Spanish cohortRodrigo Cantera Estefaníaon July 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 14. doi: 10.1515/cclm-2025-0508. Online ahead of print. ABSTRACT OBJECTIVES: The 2023 ACR/EULAR criteria aim to improve the classification of antiphospholipid syndrome (APS). This study aims to validate these criteria and compare clinical and laboratory domains between classified and non-classified patients. METHODS: A retrospective cohort study was conducted at the … Read more

Performance of afternoon (16:00 h) serum cortisol for the diagnosis of Cushing’s syndromeHippolyte Dupuison July 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 11. doi: 10.1515/cclm-2025-0133. Online ahead of print. ABSTRACT INTRODUCTION: Late-night salivary cortisol (LNSC), which assesses the loss of the circadian rhythm of cortisol, is one of the first-line tests performed to diagnose Cushing’s syndrome (CS). Unfortunately, access to LNSC is still limited in some institutions. Alternatively, midnight serum cortisol … Read more

A novel immunoprecipitation-based targeted liquid chromatography-tandem mass spectrometry analysis for accurate determination for copeptin in human serumDanni Muon July 9, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 10. doi: 10.1515/cclm-2025-0022. Online ahead of print. ABSTRACT OBJECTIVES: Copeptin, a stable and simple-to-measure surrogate marker for arginine vasopressin (AVP), demonstrates excellent clinical values, particularly in diagnosing polyuria-polydipsia syndromes. However, conventional immunoassay methods are limited and lack comparability. Our aim was to establish a targeted liquid chromatography-tandem mass spectrometry … Read more

A Modified Sampson-NIH Equation with Improved Accuracy for Estimating Low Levels of Low-Density Lipoprotein-Cholesterol

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Clin Chem. 2025 Jul 9:hvaf073. doi: 10.1093/clinchem/hvaf073. Online ahead of print. ABSTRACT BACKGROUND: Cardiovascular guidelines have long recommended low-density lipoprotein-cholesterol (LDL-C) as the primary target for lipid-lowering therapy. Recent guidelines have emphasized the importance of achieving low LDL-C levels; hence, the accurate measurement of low LDL-C is increasingly clinically relevant. METHODS: Using lipid panel test … Read more

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