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Continuous Glucose Monitors Have Acceptable Accuracy but High Discordance at High and Low Glucose Concentrations in Pediatric Hospitalized Patients

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Clin Chem. 2025 Jul 25:hvaf080. doi: 10.1093/clinchem/hvaf080. Online ahead of print. ABSTRACT BACKGROUND: Continuous glucose monitors (CGMs) assess interstitial glucose concentrations and improve diabetes management in outpatient settings. However, limited studies have assessed CGM performance in hospitalized pediatric patients, especially at high and low glucose thresholds near clinical decision limits. METHODS: This retrospective study included … Read more

A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163Victor Bruunon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0653. Online ahead of print. ABSTRACT OBJECTIVES: Hemophagocytic lymphohistiocytosis (HLH) is a severe condition requiring timely diagnosis to initiate immunomodulatory therapy. Soluble interleukin-2 receptor (sIL-2R) and soluble CD163 (sCD163) are biomarkers crucial for making this diagnosis. This study aims to establish pediatric reference intervals (RIs) for serum … Read more

Robustness of steroidomics-based machine learning for diagnosis of primary aldosteronism: a laboratory medicine perspectiveGraeme Eisenhoferon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0200. Online ahead of print. ABSTRACT OBJECTIVES: Use of machine learning (ML) in diagnostics offers promise to optimise interpretation of laboratory data and guide clinical decision-making. For this, ML-based outputs should provide robustly reproducible results at least as good as the underlying laboratory data. The objective of … Read more

Diagnostic Value of Digital Estimates of Trophoblastic Mosaicism in Genome-Wide Cell-Free Fetal DNA Screening

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Clin Chem. 2025 Jul 21:hvaf081. doi: 10.1093/clinchem/hvaf081. Online ahead of print. ABSTRACT BACKGROUND: Cell-free fetal DNA (cffDNA) screening exhibits higher sensitivity and lower false-positive rates (FPRs) compared to combined first-trimester screening for common trisomies. However, additional anomalies on other autosomes detected by genome-wide assays cause anxiety and trigger increased rates of amniocentesis. Here, we evaluated … Read more

Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis

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Clin Chem. 2025 Jul 18:hvaf074. doi: 10.1093/clinchem/hvaf074. Online ahead of print. ABSTRACT BACKGROUND: Iron deficiency (ID) is a prevalent global health issue with a major impact on well-being. Early detection of ID is crucial but challenging due to its nonspecific symptoms and the limitations of traditional diagnostic tests, which are impractical for large-scale screening. This … Read more

Can Theranos resurrect from its ashes?Miyo K Chatanakaon July 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 18. doi: 10.1515/cclm-2025-0651. Online ahead of print. ABSTRACT Theranos was a biotechnology company which, in the 2010s, promised to revolutionize traditional clinical chemistry testing by using novel technology, microvolumes of blood obtained by finger pricks, and performance of tests outside traditional clinical chemistry laboratories, such as in pharmacies. Theranos … Read more

Exploring the Role of Cardiac Troponin-Specific Autoantibodies: Prolonged Cardiac Troponin Elimination, Reduced Clearance, and Variable Interference across 5 Commercial Assays

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Clin Chem. 2025 Jul 15:hvaf077. doi: 10.1093/clinchem/hvaf077. Online ahead of print. ABSTRACT BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) assays are prone to negative and positive interferences caused by endogenous cardiac troponin-specific autoantibodies (cTnAAbs). Large macrotroponin complexes formed of cardiac troponin (cTn) and cTnAAbs may result in falsely elevated hs-cTn results. This is potentially due to reduced … Read more

MAGLUMI® Tacrolimus (CLIA) assay: analytical performances and comparison with LC-MS/MS and ARCHITECT Tacrolimus (CMIA) assayMingpeng Fuon July 15, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 16. doi: 10.1515/cclm-2025-0181. Online ahead of print. ABSTRACT OBJECTIVES: Tacrolimus has been a cornerstone of immunosuppressive therapy over the past two decades. Due to its narrow therapeutic window and pharmacokinetic variability, drug monitoring is vital for enhancing the efficacy and safety during therapy. In the present study, we evaluated … Read more

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