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A novel corrective model based on red blood cells indices and haemolysis index enables accurate unhaemolysed potassium determination in haemolysed samples – Hemokalc projectCharles R Lefèvreon August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0330. Online ahead of print. ABSTRACT OBJECTIVES: Haemolysis is a major preanalytical issue that affects potassium measurements, often leading to sample rejection and delayed clinical management. This study proposes a novel corrective model for accurate unhaemolysed potassium prediction. METHODS: Blood samples from 14 healthy volunteers were used … Read more

Total laboratory automation: fit for its intended purposes?Mario Plebanion August 7, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0855. Online ahead of print. ABSTRACT Since the 1980s, automation has profoundly transformed clinical laboratory operations, enhancing efficiency, standardization, and throughput. This technological evolution has enabled laboratories to meet rising testing demands, address persistent workforce shortages, and control operational costs. Beyond analytical consolidation, significant progress has been … Read more

Establishment of region-, age- and sex-specific reference intervals for aldosterone and renin with sandwich chemiluminescence immunoassaysLin-Lin Caoon August 7, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0587. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of plasma aldosterone (ALD) and renin is important in primary aldosteronism screening and diagnosis. The high variability of ALD and renin due to salt intake, age, and sex, as well as the lack of immunoassay standardization necessitates the … Read more

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