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Low vacuum (3 mL) rapid serum tubes offer better protection from hemolysis than plasma separator tubes collected in the emergency department​​on August 14, 2025 at 9:45 am

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Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Emily Shang, Taylor Takasugi, Pedro Prellwitz, Cristina Figueroa Villalba, Rohit B. Sangal, Arjun K. Venkatesh, Lisa Maciejak, Erica Oberle, Joe M. El-Khoury

Comparative analysis of population-based and personalized reference intervals for biochemical markers in peri-menopausal women: population from the PALM cohort studyJiaming Wuon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0658. Online ahead of print. ABSTRACT OBJECTIVES: Significant changes in clinical biochemical markers occur during the peri-menopausal period. Traditional population-based reference intervals (popRIs) may not reflect individual physiological variability, limiting clinical interpretation. This study aimed to establish personalized reference intervals (prRIs) for menopausal women and compare them … Read more

Evaluating large language models as clinical laboratory test recommenders in primary and emergency care: a crucial step in clinical decision makingAhmed Medhat Zayedon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0647. Online ahead of print. ABSTRACT OBJECTIVES: Large language models (LLMs), such as OpenAI’s GPT-4o, have demonstrated considerable promise in transforming clinical decision support systems. In this study, we focused on a single but crucial task of clinical decision-making: laboratory test ordering. METHODS: We evaluated the self-consistency … Read more

The current status of serum insulin measurements and the need for standardizationCurt Rohlfingon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0552. Online ahead of print. ABSTRACT OBJECTIVES: Insulin assays are used to assess insulin resistance and to aid in the diagnosis of conditions such as insulinoma and various forms of hypoglycemia. However, discrepancies among commercial assays limit their clinical and research utility. This study evaluates the current … Read more

Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications

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Clin Chem. 2025 Aug 12:hvaf082. doi: 10.1093/clinchem/hvaf082. Online ahead of print. ABSTRACT BACKGROUND: There is increasing interest in the use of circulating cell-free RNA (cfRNA) in plasma as an analyte for diagnosing and monitoring disease. While it is known that cfRNA can also be isolated from urine, the diagnostic potential of urine cfRNA, particularly relative … Read more

Allelic Cataloging of RHD-RHCE Reference Sequences Using Targeted Long-Read Sequencing

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Clin Chem. 2025 Aug 8:hvaf090. doi: 10.1093/clinchem/hvaf090. Online ahead of print. ABSTRACT BACKGROUND: Implementation of blood group genotyping has offered substantial benefits in transfusion medicine. However, the complex molecular basis of Rh antigen expression and a high degree of sequence homology between RHD and RHCE have long limited the accuracy of blood group genotyping, highlighting … Read more

Gene Therapy for Hemophilias: Opportunities and Challenges for the Clinical Laboratory

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Clin Chem. 2025 Aug 7:hvaf085. doi: 10.1093/clinchem/hvaf085. Online ahead of print. ABSTRACT BACKGROUND: Hemophilia A and B are X-linked coagulation disorders characterized by low or dysfunctional Factor VIII (FVIII) or IX (FIX), respectively. Currently, hemophilia A and B are treated by FVIII/FIX replacement therapy with plasma-derived or recombinant products or by FVIII-mimetic agents (e.g., emicizumab). … Read more

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