ccinfoadmin Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Simmi Patel, Octavia M. Peck Palmer, Chanda B. Lay, Kathleen Mulvey, Michael R. Shurin, Sarah E. Wheeler
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Bünyamin Kanat, Gokce Atikeler, Elif Azarsiz
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Alan Carvalho Dias, Derliane de Oliveira, Fernando de Almeida Berlitz, José Antônio Tesser Poloni, Wilson Shcolnik, Claudia Maria Meira Dias, Daniane Grando Remor Canalli, Luisane Maria Falci Vieira, Bruna Dolci Andreguetto, Felipe Magalhães Furtado, Rafael Monsores Lopes, Adriano Basques Fernandes, Leonardo de Souza … Read more
Clin Chem. 2025 Aug 22:hvaf092. doi: 10.1093/clinchem/hvaf092. Online ahead of print. ABSTRACT BACKGROUND: Population-wide reference intervals (RIpop) are commonly used in laboratory medicine but may not reflect an individual’s tightly regulated homeostatic interval. Personalized reference intervals (RIper) could enhance diagnostic precision by accounting for individual variability. A parametric empirical Bayes (PEB) framework stabilizes individual estimates … Read more
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Lisa V. Kalman, Yang Xia, Ya-Lin A. Huang, Kate Buchacz, Rex Astles, Jesse O’Shea
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0378. Online ahead of print. ABSTRACT OBJECTIVES: Insulin-like growth factor binding protein-4 (IGFBP-4) fragments are reported as emerging biomarkers for cardiovascular disease (CVD) risk assessment. To ensure data reliability and improve clinical application, the first automatic chemiluminescent immunoassay (CLIA) for NT-IGFBP-4 was developed and its distribution across … Read more
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0743. Online ahead of print. ABSTRACT OBJECTIVES: Accurate quantification of aldosterone is critical for screening and diagnosing primary aldosteronism (PA). Current competitive chemiluminescence immunoassays (cCLIA) overestimate plasma aldosterone concentration (PAC) compared to liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, LC-MS/MS is technically demanding and time-consuming, limiting its widespread … Read more
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0870. Online ahead of print. ABSTRACT OBJECTIVES: Glial fibrillary acidic protein (GFAP) is a well-established biomarker of astrocytic activation associated with neurodegenerative diseases, neuroinflammatory disorders, and traumatic brain injury. With increasing interest in blood-based biomarkers, the need for analytically validated assays and reliable reference intervals is critical … Read more
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0137. Online ahead of print. ABSTRACT OBJECTIVES: Autoantibodies against structure elements of the pancreas are an essential part of laboratory diagnosis of diabetes mellitus. The heterogeneity of current methods and difficult inter-assay comparability of results poses challenges to both clinical interpretation as well as research integrity. METHODS: … Read more
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Shiang-Fen Huang, Fu-Der Wang, Chia-Chang Huang, Kun-Ta Chou, Yu-Chi Huang, Ping-Feng Wu, Chen-Te Lee, Ying-Ying Yang
