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In Vitro Metabolic Profiling of 18 Semi-Synthetic Cannabinoids-Hexahydrocannabinol (HHC) and Its Analogs-with Identification in an Authentic Hexahydrocannabiphorol (HHCP) Urine Sample

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Clin Chem. 2025 Aug 25:hvaf087. doi: 10.1093/clinchem/hvaf087. Online ahead of print. ABSTRACT BACKGROUND: Hexahydrocannabinol (HHC) and its analogs are recent additions to semi-synthetic cannabinoids in the recreational drug market. Here, the metabolism of 18 HHC analogs was compared to gain a comprehensive understanding of the structure-metabolism relationship of HHC analogs and to identify urinary biomarkers. … Read more

False-positive cardiac troponin I values due to macrotroponin in healthy athletes after COVID-19Angelika Hammerer-Lercheron August 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 17. doi: 10.1515/cclm-2025-0427. Online ahead of print. ABSTRACT OBJECTIVES: Cardiac troponins (cTn) are used to detect and quantify acute cardiomyocyte injury. In patients presenting with symptoms that could indicate myocarditis, elevated cTn concentrations typically mandate cardiac catheterization and heart muscle biopsy or cardiac magnetic resonance imaging (CMR). Accordingly, increased … Read more

Age distorts the interpretation of FIB-4Arne Åsbergon August 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 26. doi: 10.1515/cclm-2025-0615. Online ahead of print. ABSTRACT OBJECTIVES: To determine whether the diagnostic accuracy of the liver fibrosis marker FIB-4 and the likelihood ratios (LRs) of specific FIB-4 values vary with age. METHODS: We used a published dataset of 540 patients diagnosed with non-alcoholic fatty liver disease (NAFLD) … Read more

Quality assurance using patient split samples: recommendations for primary healthcare laboratoriesAnne Stavelinon August 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 26. doi: 10.1515/cclm-2025-0818. Online ahead of print. ABSTRACT OBJECTIVES: The increasing adoption of point-of-care testing (POCT) in primary healthcare highlights the need for robust quality assurance (QA) procedures to ensure result reliability. The patient split sample approach, i.e. comparing POCT and central laboratory results from the same patient, can … Read more

Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use

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Clin Chem. 2025 Aug 25:hvaf094. doi: 10.1093/clinchem/hvaf094. Online ahead of print. ABSTRACT BACKGROUND: Protein biomarkers are routinely measured for disease diagnosis and prognosis in clinical laboratories. Since most assays focus on protein quantity, information about proteoforms is often not acquired. Proteoforms of a protein represent the complex integration of genetic polymorphism, alternative splicing of RNA … Read more

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