ccinfoadmin

Optimizing diagnostic thresholds of total vitamin B12 (B12) for identifying cobalamin deficiency in adults with macrocytic anemiaMichela Pellosoon February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 13. doi: 10.1515/cclm-2025-1722. Online ahead of print. ABSTRACT OBJECTIVES: Identifying individuals with vitamin B12 (B12) deficiency is challenging due to poor harmonization across total B12 assays. To establish clinically meaningful thresholds for the Roche assay, we characterized B12 concentrations associated with deficiency by comparing individuals with macrocytic anemia and … Read more

Analytical performance of the Roche Elecsys TnT hs Gen 6 immunoassayMarco Tosion February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2026-0115. Online ahead of print. ABSTRACT OBJECTIVES: The acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide, with timely diagnosis being critical for improving outcomes. Since high-sensitivity cardiac troponin (hs-cTn) assays have become the gold standard for detecting myocardial injury, this study aimed … Read more

On the cusp of global lipoprotein(a) standardizationChrista M Cobbaerton February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 16. doi: 10.1515/cclm-2026-0149. Online ahead of print. ABSTRACT Lipoprotein(a) (Lp(a)) has the reputation of being the most misunderstood metric in laboratory medicine. The unique apolipoprotein(a) (apo(a)) in Lp(a) is very heterogenous, the kringle IV domain of apo(a) being formed by 12-50 kringles due to 3 to ∼40 KIV2 repeats. … Read more

Age- and sex-specific reference intervals for 11-oxygenated androgens from infancy throughout childhood and adulthoodRobert Zeidleron February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1440. Online ahead of print. ABSTRACT OBJECTIVES: The adrenal glands are the main source of 11-oxygenated androgens (11-OAs), including the potent 11-ketotestosterone (11-KT) and the weaker metabolites 11β-hydroxyandrostenedione (11-OHA4), 11β-hydroxytestosterone (11-OHT) and 11-ketoandrostenedione (11-KA4). Due to their adrenal origin, 11-OAs allow the differentiation of adrenal and extra-adrenal-produced … Read more

From ordering to interpretation: a comprehensive framework for laboratory test indicationsJasmin Weningeron February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 6. doi: 10.1515/cclm-2025-1531. Online ahead of print. ABSTRACT OBJECTIVES: Clinical intent for laboratory testing (“indication”) is rarely recorded in structured form, limiting contextual interpretation, auditability, and utilization stewardship. We developed a comprehensive, and clinically applicable framework that standardizes laboratory test indications and links them to indication-dependent utilization and interpretation. … Read more

Kidney damage biomarkers in predicting renal complications of allogeneic hematopoietic cell transplantation: a pilot prospective observational study​Dorota Szcześ Marcin Żórawski Ewa Koc-Żórawska Monika Paskudzka Longin Niemczyk Agnieszka Tomaszewska Magdalena Tormanowska Ewa Karakulska-Prystupiuk Piotr Kacprzyk Kazimierz Hałaburda Olga Ciepiela Marlena Kwiatkowska-Stawiarczyk Anna Rodziewicz-Lurzyńska Jarosław Biliński Grzegorz Władysław Basak Jolanta Małyszko a Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Polandb Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Polandc Department of Cardiology, Lipidology and Internal Medicine with Cardiac Intensive Care Unit, Medical University of Bialystok, Bialystok, Polandd The Academy of Applied Medical and Social Sciences, Elbląg, Polande Second Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Białystok, Polandf Central Laboratory, Central Teaching Hospital of University Clinical Center, Medical University of Warsaw, Warsaw, Polandg Institute of Hematology and Transfusion Medicine, Warsaw, Polandon February 4, 2026 at 12:04 pm

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Volume 86, Issue 1, February 2026, Page 53-65.

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