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Comparison of the cardiac troponin I-cardiac troponin T-troponin C complex and cardiac troponin I and T in distinguishing myocardial infarction using a single sample at presentationLing Lion November 10, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 11. doi: 10.1515/cclm-2025-0385. Online ahead of print. ABSTRACT OBJECTIVES: The potential relationship between cardiac troponin (cTn) composition and etiologies of myocardial injury may provide diagnostic insights for myocardial infarction (MI). We compared the performance of novel ternary cTnI-cTnT-TnC complex (ITC) assays with high-sensitivity (hs)-cTnI and hs-cTnT in differentiating MI … Read more

Thresholds adjustments and impact on clinical performance of three FIT assays in a colorectal cancer screening programJean Dubéon November 9, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0546. Online ahead of print. ABSTRACT OBJECTIVES: Fecal immunochemical tests (FITs) from various manufacturers yield different results, leading to variable positivity rates and clinical performance. These differences can influence the healthcare costs of a colorectal cancer screening program (CRC-SP), specifically when switching among FIT manufacturers. The analytical … Read more

Integrated Genotyping Strategies for Uncovering Detailed Haplotype Structures and Characterization of DMD Duplications

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Clin Chem. 2025 Nov 7:hvaf136. doi: 10.1093/clinchem/hvaf136. Online ahead of print. ABSTRACT BACKGROUND: Duchenne and Becker muscular dystrophies are X-linked neuromuscular disorders caused by mutations in the dystrophin gene (DMD). Duplications account for approximately 10% of pathogenic variants, but their structural complexity and variable clinical impact present significant challenges in pathogenicity interpretation. METHODS: We retrospectively … Read more

Validation of a Multiplex mRNA- and gDNA-Based Droplet Digital PCR Assay in Acute Myeloid Leukemia Patients with an NPM1 Mutation

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Clin Chem. 2025 Nov 6:hvaf142. doi: 10.1093/clinchem/hvaf142. Online ahead of print. ABSTRACT BACKGROUND: NPM1 is a disease-defining gene in the diagnosis of acute myeloid leukemia (AML) and is important for measurable residual disease (MRD) assessment. Over 50 different NPM1 mutations have been described, but only the 3 most common are routinely monitored during follow-up. METHODS: … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid glucuronide in human serum and plasmaTobias Schierscheron November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1052. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid glucuronide (MPAG). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was … Read more

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