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Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?

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Clin Chem. 2025 Nov 13:hvaf162. doi: 10.1093/clinchem/hvaf162. Online ahead of print. ABSTRACT BACKGROUND: Phosphorylated tau 217 (p-tau217) has emerged as a leading blood-based biomarker for Alzheimer disease (AD). While typically measured in plasma, serum is a widely used matrix in clinical laboratories, yet few p-tau217 assays have been validated for serum. Evaluating serum p-tau217 performance … Read more

Capillary blood in core laboratories: current and future challengesÁlvaro Gonzálezon November 13, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 14. doi: 10.1515/cclm-2025-0888. Online ahead of print. ABSTRACT Capillary blood sampling is gaining recognition as a patient-centered alternative to traditional venipuncture. Its main advantages are that it is less invasive, reduces patient discomfort, and potentially can be performed without the direct supervision of a healthcare professional. These features could … Read more

Per Se Driving Under the Influence of Cannabis Statutes and Blood Delta-9-Tetrahydrocannabinol Concentrations following Short-Term Cannabis Abstinence

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Clin Chem. 2025 Nov 12:hvaf121. doi: 10.1093/clinchem/hvaf121. Online ahead of print. ABSTRACT BACKGROUND: Several US states have per se laws using 2 or 5 ng/mL of delta-9-tetrahydrocannabinol (THC) as cutpoints for driving under the influence of cannabis, while some have zero-tolerance statutes. These cutpoints are considered prima facia evidence of driving impairment. METHODS: In a … Read more

Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home samplingLiesl Heughebaerton November 12, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 13. doi: 10.1515/cclm-2025-1002. Online ahead of print. ABSTRACT OBJECTIVES: As (a lack of) vitamin D has been linked to a wide variety of chronic diseases, there is growing interest in generating robust epidemiological data. Consequently, the need for large-scale biological sample collection has increased. In this context, dried blood … Read more

Emerging Threat of Xylazine

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Clin Chem. 2025 Nov 11:hvaf147. doi: 10.1093/clinchem/hvaf147. Online ahead of print. ABSTRACT BACKGROUND: The increasing reports of xylazine in clinical and postmortem toxicology necessitate a survey of its clinical impact. This review examines reports of xylazine across the peer-reviewed literature and grey literature (government and public health reports). CONTENT: Before 2005, reports of xylazine abuse … Read more

Prognostic utility of serial procalcitonin measurements in ICU sepsis: a laboratory-led modelling approach in a resource-limited setting procalcitonin modelling for sepsis mortality in a low-resource ICUAaqilah Fataaron November 11, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 12. doi: 10.1515/cclm-2025-0778. Online ahead of print. ABSTRACT OBJECTIVES: Procalcitonin (PCT) is increasingly used to support sepsis diagnosis, but its role in predicting outcomes remains uncertain, particularly in low-resource settings. We evaluated whether single and serial PCT measurements were associated with 28-day mortality in critically ill adults with suspected … Read more

VeRUS: verification of reference intervals based on the uncertainty of samplingMatthias Beckon November 10, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 11. doi: 10.1515/cclm-2025-0728. Online ahead of print. ABSTRACT OBJECTIVES: Laboratories are required to routinely verify reported reference intervals (RIs), but common verification methods like the CLSI-EP28-A3c binomial test are often impractical due to sample collection requirements. Indirect verification methods like equivalence limits (ELs) use routine data from patient care … Read more

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