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Association of Serum Uromodulin and Carbamylated Albumin with All-Cause and Cardiovascular Mortality in Patients with No or Mild Chronic Kidney Disease

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Clin Chem. 2025 Dec 16:hvaf166. doi: 10.1093/clinchem/hvaf166. Online ahead of print. ABSTRACT BACKGROUND: Serum uromodulin (SUmod) and carbamylated albumin (C-Alb) are emerging biomarkers for chronic kidney disease (CKD) progression and mortality. SUmod reflects tubular health, while C-Alb is associated with excretory kidney function, CKD progression, and cardiovascular (CV) mortality. We hypothesized that the combined use … Read more

Serial measurements of neuron specific enolase, glial fibrillary acidic protein and neurofilament light for mortality prediction in patients with severe acute brain injury in the ICUWolmet E Haksteenon December 16, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 17. doi: 10.1515/cclm-2025-1315. Online ahead of print. ABSTRACT OBJECTIVES: Prognostication in patients with severe acute brain injury (SABI) in the Intensive Care Unit (ICU) is complex, often requiring early decisions on life-sustaining therapy. Serum biomarkers such as neurofilament light (NFL), glial fibrillary acidic protein (GFAP) and neuron specific enolase … Read more

Artificial intelligence and machine learning in thrombosis and hemostasis: a scoping review of clinical and laboratory applications, challenges, and future directionsMohammad A Altememion December 16, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 17. doi: 10.1515/cclm-2025-1450. Online ahead of print. ABSTRACT This scoping review followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines to systematically map the current landscape of artificial intelligence (AI) and machine learning (ML) applications in the field of thrombosis and hemostasis … Read more

Quantitative analysis of phylloquinone (vitamin K1) and menaquinone (vitamin K2) in serum of Russians by liquid chromatography-tandem mass spectrometryMikhail Vokuevon December 15, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 16. doi: 10.1515/cclm-2025-0719. Online ahead of print. ABSTRACT OBJECTIVES: Vitamin K homologues are essential to human health, and their concentrations in biological samples serve as valuable diagnostic biomarkers. This study was aimed to develop a method for determining vitamins K1 (phylloquinone, VK1) and K2 (menaquinone, MK-4) in human serum. … Read more

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