ccinfoadmin – Page 14 – Clinical Chemistry INFO

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of voriconazole in human serum and plasmaMarie Kubicovaon January 23, 2026 at 11:00 am

January 23, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-1371. Online ahead of print. ABSTRACT OBJECTIVES: Voriconazole is an antifungal agent measured in serum and plasma for therapeutic drug monitoring. This study aimed to develop a robust isotope-dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) reference measurement procedure (RMP) to ensure accurate and reliable quantification in compliance with … Read more

Acquired bisalbuminemia: A case reporton January 23, 2026 at 12:30 pm

January 23, 2026 by ccinfoadmin

Publication date: Available online 22 January 2026 Source: Clinical Biochemistry Author(s): R. Addesso, S. Sarpa, M. Ferrandino, C. Giorgione, A. Marrone, M. Savoia, G. Castaldo

Comparison of six serum analyte workflows using routine liquid chromatography-tandem mass spectrometry methods at multiple laboratories with the Cobas i 601 analyzer, an automated mass spectrometry systemPieter Vermeerschon January 23, 2026 at 11:00 am

January 23, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-0994. Online ahead of print. ABSTRACT OBJECTIVES: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers substantial analytical advantages over traditional immunoassay methods, including greater specificity and robustness. Conventional LC-MS/MS methods are labor-intensive, requiring highly trained, dedicated laboratory staff. The Cobas® i 601 analyzer (Roche Diagnostics International Ltd., Rotkreuz, Switzerland) … Read more

ALT-triggered reflex AST testing in health check-ups: A decision curve analysison January 22, 2026 at 9:35 am

January 22, 2026 by ccinfoadmin

Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Shu-Mei Bai, Xu-Xiao Guo, Guo-Ming Zhang

Exosome biosensors for detection of Lung canceron January 22, 2026 at 9:35 am

January 22, 2026 by ccinfoadmin

Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Obaid Afzal, Pavan Goud, Kavita Goyal, Ali Altharawi, Mubarak A. Alamri, Manal A. Alossaimi, Abdulmalik S.A. Altamimi, Surya Nath Pandey

An isotope dilution-liquid chromatography tandem mass spectrometry-based candidate reference measurement procedure for the quantification of dehydroepiandrosterone in human serum and plasmaLea Lewinon January 21, 2026 at 11:00 am

January 22, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 22. doi: 10.1515/cclm-2025-1156. Online ahead of print. ABSTRACT OBJECTIVES: Dehydroepiandrosterone (DHEA) is a steroid prohormone and important precursor for estrogen and testosterone biosynthesis. For differential diagnosis of sexual development disorders (e.g., polycystic ovary syndrome, congenital adrenal hyperplasia), accurate measurement of DHEA in clinical testing is essential. To address that … Read more

Science, Quality and Value of Laboratory MedicineMario Plebanion January 21, 2026 at 11:00 am

January 22, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 22. doi: 10.1515/cclm-2026-0041. Online ahead of print. ABSTRACT The Meeting on Science, Quality and Value of Laboratory Medicine was held on 11 December 2025 in Padua, immediately preceding the 7th European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Conference on the Preanalytical Phase. For organizational reasons, the meeting … Read more

Establishing Reference Values in Healthy Participants for the Cardiac Troponin T High-Sensitivity Gen 6 Assay: REF-TSIX Global Reference Study

January 22, 2026 by ccinfoadmin

Clin Chem. 2026 Jan 21:hvag011. doi: 10.1093/clinchem/hvag011. Online ahead of print. ABSTRACT BACKGROUND: Measurement of cardiac troponin (cTn) using high-sensitivity assays is recommended for the diagnosis of myocardial infarction. We determined sex-specific and uniform 99th percentile upper reference limits (URLs) using the new Elecsys® Troponin T high-sensitivity Gen 6 assay in a global, healthy reference … Read more

Why the Same Cold Can Be a Sniffle for Some and a Crisis for Otherson January 20, 2026 at 1:00 pm

January 21, 2026 by ccinfoadmin

It’s not the rhinovirus itself but the body’s early immune response that determines whether the common cold stays mild or flares into something more dangerous, a new study finds.

Comparative Evaluation of Free Light Chain Assays in AL Amyloidosis: Performance of Sebia Versus Freelite and N-Latexon January 21, 2026 at 3:02 pm

January 21, 2026 by ccinfoadmin

Publication date: Available online 21 January 2026 Source: Practical Laboratory Medicine Author(s): Frances Zhao, Carel Pretorius, Peter Mollee