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Underreporting of synthetic cathinone poisoning with clinical immunoassays: An experimental and observational study​Théo Willeman, Mathis Laudet, Bruno Revol, Coralie Boudin, Hélène Eysseric-Guerin, Virginie Scolan, Françoise Stanke-Labesque1Laboratoire de Pharmacologie, Pharmacogénétique et Toxicologie, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France2Clinique de Médecine Légale, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France3CEIP-Addictovigilance, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France4Laboratoire HP2 Inserm U1300, 27015University Grenoble Alpes, Grenoble, France5Laboratoire de Médecine Légale, 27015University Grenoble Alpes, Grenoble, Franceon March 22, 2025 at 3:44 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThere is an increasing global concern about the use of synthetic cathinones (SCs). Detecting these drugs in human urine samples can be difficult, particularly in emergency settings. Cross-reactivity has been described for several immunoassays. …

Sigma metrics for assessing the analytical performance of 14 biochemical analytes in Mansoura university children’s hospital laboratories (MUCHLs) using CLIA LIMITS 1988 & 2024​Nada Karam, Reham M El-Farahaty, Abdel- Hady El-Gilany, Nessma A Nosser1Clinical Pathology Department, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypt2Public Health & Preventive Medicine, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypton March 14, 2025 at 4:51 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionAnalytical quality is a crucial prerequisite for best practice in medical laboratory. Six-Sigma Methodology (SM) is a quality measurement tool used to evaluate laboratory performance. This study aims to assess the analytical phase baseline …

Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma

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Clin Chem. 2025 Apr 2:hvaf030. doi: 10.1093/clinchem/hvaf030. Online ahead of print. ABSTRACT INTRODUCTION: The number of assays on proteomic platforms has grown rapidly. The leading platforms, SomaScan and Olink, have strengths and limitations. Comparisons of precision on the latest platforms-SomaScan 11k and Olink Explore HT-have not yet been established. METHODS: Among 102 participants in the … Read more

Self-sampling of capillary blood for safety monitoring of DMARD therapy in patients with rheumatic disease: a feasibility and method-comparison study​Josefine Bak H. Adelhelm Trine Rennebod Larsen Ulla Jakobsen Pernille J. Vinholt Maria Boysen Sandberg Inger Marie Jensen Hansen Søren Andreas Just a Department of Clinical Biochemistry, Odense University Hospital, Odense C, Denmarkb Department of Clinical Biochemistry, Odense University Hospital, Svendborg, Denmarkc Department of Medicine, Section of Rheumatology, Svendborg Hospital – Odense University Hospital, Svendborg, Denmarkon February 7, 2025 at 5:34 am

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Volume 85, Issue 2, April 2025, Page 108-115.

Comparison of two automated immunoassays for quantifying ProGRP, SCC and HE4 in serum: impact on diagnostic accuracy​Jaime I. Sainz de Medrano Javier Laguna Judit Julian Xavier Filella Aleix Fabregat María Luquin Harol H. Hurtado Alba García Humanes Manuel Morales-Ruiz Esther Fernández-Galán a Biochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spainb Servicio de Análisis Clínicos, Hospital Universitario de Navarra, Pamplona, Spainc Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spaind Commission for the Biochemical Evaluation of the Hepatic Disease-SEQCML, Barcelona, Spaine Biomedicine Department, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spainon February 15, 2025 at 5:28 am

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Volume 85, Issue 2, April 2025, Page 116-124.

Assessment of large language models in medical quizzes for clinical chemistry and laboratory management: implications and applications for healthcare artificial intelligence​Won Young Heo Hyung-Doo Park a Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Koreab Department of Laboratory Medicine, Gimpo Woori Hospital, Gimpo, Koreac Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University School of Medicine, Seoul, Koreaon February 19, 2025 at 6:06 am

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Volume 85, Issue 2, April 2025, Page 125-132.

The HUNT study: long-term within-subject variation of thyroid stimulating hormone (TSH)​Arne Åsberg Marius Berg Gunhild Garmo Hov Ingrid Alsos Lian Lena Løfblad Gustav Mikkelsen a Department of Clinical Chemistry, St. Olav’s Hospital, Trondheim, Norwayb Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norwayon March 8, 2025 at 12:52 pm

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Volume 85, Issue 2, April 2025, Page 143-147.

A deep dive into four thyroglobulin immunoassays from analytical perspective​Tuba Saadet Deveci Bulut Muhittin Abdulkadir Serdar Mehmet Muhittin Yalçın Meriç Coşkun Aylar Poyraz Seda Gökgöz Acar Gizem Yaz Aydın Özlem Gülbahar a Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkeyb Department of Medical Biochemistry, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkeyc Department of Endocrinology and Metabolism, Gazi University School of Medicine, Ankara, Turkeyd Department of Pathology, Gazi University School of Medicine, Ankara, Turkeyon March 17, 2025 at 12:42 pm

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Volume 85, Issue 2, April 2025, Page 148-159.

Performance of enzymatic creatinine methods in the pediatric concentration range​Hilda Hallander Magnus Lindén Catarina Lindqvist Anders Olsson Sara Marie Larsson a Department of Clinical Chemistry, Halland Hospital, Varberg and Halmstad, Swedenb Department of Pediatrics, Halland Hospital, Halmstad, Swedenc Department of Pediatrics, Institute of Medical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Swedend Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Swedene Department of Clinical Sciences Lund, Pediatrics, Lund University, Lund, Swedenon February 17, 2025 at 1:35 am

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Volume 85, Issue 2, April 2025, Page 93-100.

CgA100 – eGFR-adjusted serum chromogranin A​Arne Åsberg Gustav Mikkelsen Lena Løfblad a Department of Clinical Chemistry, St. Olav hospital, Trondheim University Hospital, Trondheim, Norwayb Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norwayon February 24, 2025 at 10:12 am

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Volume 85, Issue 2, April 2025, Page 133-137.

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