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Methylglyoxal-Induced Glycation of Plasma Albumin: From Biomarker Discovery to Clinical Use for Prediction of New-Onset Diabetes in Individuals with Prediabetes

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Clin Chem. 2025 Apr 7:hvaf035. doi: 10.1093/clinchem/hvaf035. Online ahead of print. ABSTRACT BACKGROUND: Methylglyoxal (MGO) is a potent glycating agent that contributes to the pathogenesis of diabetes. However, MGO is unstable in plasma without demanding sample preparation at blood collection, limiting its clinical utility as a biomarker. We aimed to discover reliable MGO-glycated albumin (ALB)-derived … Read more

Prevalence and re-evaluation of macroprolactinemia in hyperprolactinemic patients: a retrospective study in the Turkish populationOsman Oğuzon April 4, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 7. doi: 10.1515/cclm-2025-0177. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to investigate the prevalence of macroprolactinemia and the changes in hyperprolactinemia status over time among hyperprolactinemic patients in the Turkish population. METHODS: A retrospective study was conducted on 3,013 patient records from a central university hospital between … Read more

Screening primary aldosteronism by plasma aldosterone-to-angiotensin II ratioClara Wai-Shan Loon April 4, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 7. doi: 10.1515/cclm-2024-1312. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is a common cause of secondary hypertension. The aldosterone-to-renin ratio (ARR) is the current recommended biomarker for PA screening, but it has limitations. This study evaluates another ratio, the aldosterone-to-angiotensin II ratio (AAIIR), as an alternative screening … Read more

Improving the efficiency of quality control in clinical laboratory with an integrated PBRTQC system based on patient riskXincen Duanon April 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 4. doi: 10.1515/cclm-2025-0163. Online ahead of print. ABSTRACT OBJECTIVES: Recent advances in information technology have renewed interest in patient-based real-time quality control (PBRTQC) as an alternative to internal quality control (IQC). However, since regulations mandate IQC, PBRTQC can only be implemented as a separate system. The additional labor required … Read more

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