High-throughput quantification of tacrolimus in whole blood by acoustic ejection mass spectrometry: analytical validation and comparative assessment against conventional LC-MS/MS for therapeutic drug monitoring​on March 31, 2026 at 6:16 am

Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Xin-Yu Wu, Xiao-Kang Fu, Ao Li, Wei Zhang, Han-Peng Jiang, Na An, Quan-Fei Zhu, Shao-Ting Wang, Yu-Qi Feng  

Thyroid hormone profile and biological variation in a population of athletes during an entire sport season​on March 31, 2026 at 6:16 am

Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Isabel Moreno-Parro, Jorge Díaz-Garzón, Berta Sufrate-Vergara, Aasne K. Aarsand, Sverre Sandberg, Anna Carobene, Outi Itkonen, William Bartlett, Abdurrahman Coskun, Niels Jonker, Pilar Fernández-Calle, on behalf of theEuropean Federation of Clinical Chemistry and Biological Variation Committee  

Current and Future Indication for Testing and Use of Cardiac Troponin in Children

Clin Chem. 2026 Mar 27:hvag021. doi: 10.1093/clinchem/hvag021. Online ahead of print. ABSTRACT BACKGROUND: The clinical use and interpretation of cardiac troponins (cTn) in pediatric patients is heterogeneous. CONTENT: This review is based on an appraisal and synthesis of the available literature and discussions between International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical … Read more

Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers

Clin Chem. 2026 Mar 27:hvag018. doi: 10.1093/clinchem/hvag018. Online ahead of print. ABSTRACT BACKGROUND: Bisulfite conversion remains the gold standard method for DNA methylation analysis but has known limitations. Enzymatic conversion has recently been developed and overcomes some of these pitfalls. This study compared both methods by measuring known colorectal cancer (CRC) methylated biomarkers in colorectal … Read more

Exploring the stability of whole blood samples for remote health care applications towards reliable home-based blood testing​M. H. Elise van Driel, Alan Han, Dirk J. Grünhagen, Christian Ramakers1Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands,2Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlandson February 3, 2026 at 1:41 am

Annals of Clinical Biochemistry, Ahead of Print. ObjectivesTo evaluate the stability of commonly used biomarkers in whole blood under various storage conditions, in order to assess their suitability for home-based blood collection in remote care settings.MethodsWhole blood samples were stored at 4–8°C, …

Predicting the outcome of short Synacthen test based on baseline cortisol levels: A single-centered retrospective cohort study at a tertiary care hospital in Sri Lanka​Premadasa T, Samarathunga EPA, Sujith EM, Shameela NMF, Basnayaka BMKS, Antonypillai CN, Jayawardana RDP1Department of Chemical Pathology, National Hospital, Kandy, Sri Lanka2Department of Quality Control, National Hospital, Kandy, Sri Lanka3Department of Diabetic and Endocrinology, National Hospital, Kandy, Sri Lankaon September 16, 2025 at 2:39 am

Annals of Clinical Biochemistry, Ahead of Print. IntroductionShort Synacthen Test (SST), a standard diagnostic test to confirm Adrenal insufficiency (AI), involves substantial expenses.ObjectivesThis study aimed to assess the predictive value of baseline Cortisol levels for SST outcomes and establish …

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