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Cerebrospinal fluid leptin in Alzheimer’s disease: relationship to plasma levels and to cerebrospinal amyloidElodie Bouaziz-Amaron August 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 1. doi: 10.1515/cclm-2025-0304. Online ahead of print. ABSTRACT OBJECTIVES: Dysregulation of brain leptin signaling contributes to Alzheimer’s disease (AD) pathophysiology, but plasma leptin may not accurately reflect central nervous system activity. This study examined the correlation between plasma and cerebrospinal fluid (CSF) leptin levels and their relationship with beta-amyloid … Read more

Fecal leukocyte esterase levels predict endoscopic severity as an alternative biomarker in inflammatory bowel diseaseFeng-Pai Tsaion August 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 1. doi: 10.1515/cclm-2025-0747. Online ahead of print. ABSTRACT OBJECTIVES: Our previous study revealed a correlation between fecal leukocyte esterase and fecal calprotectin levels. This study assessed the predictive value of fecal leukocyte esterase compared with fecal calprotectin and C-reactive protein of inflammatory bowel disease. METHODS: Patients with inflammatory bowel … Read more

Failure Mode and Effects Analysis (FMEA) integrating quality indicators for risk assessment of the total testing process in human papillomavirus genotyping testing: a proactive risk analysis model for molecular diagnosticsTingting Lion August 29, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 29. doi: 10.1515/cclm-2025-0598. Online ahead of print. ABSTRACT OBJECTIVES: To develop a proactive risk assessment model for human papillomavirus (HPV) genotyping testing by integrating Failure Mode and Effects Analysis (FMEA) with quality indicators (QIs), ensuring compliance with ISO 15189:2022 and improving diagnostic accuracy. METHODS: A multidisciplinary team designed and … Read more

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