Ramifications of Biological Variability on Tests for Primary Aldosteronism Screening
Clin Chem. 2026 Aug 24:hvag104. doi: 10.1093/clinchem/hvag104. Online ahead of print. NO ABSTRACT PMID:42634885 | DOI:10.1093/clinchem/hvag104
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Genetic Investigation of X-Linked Defects with Optimized Targeted Long-Read Sequencing
Clin Chem. 2026 Aug 24:hvag088. doi: 10.1093/clinchem/hvag088. Online ahead of print. ABSTRACT BACKGROUND: X-linked genetic diseases affect males and females through different inheritance patterns influenced by sex, where differential methylation caused by X-chromosome inactivation can present with a range of asymptomatic, mild, and severe symptoms in females. Targeted long-read sequencing (LRS) through adaptive sampling (AS) … Read more
A roadmap for standardization of serum albumin measurementsMauro Panteghinion August 22, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1215. Online ahead of print. ABSTRACT Albumin measurements in serum have important diagnostic and prognostic roles. However, non-standardized measurement procedures are still used in medical laboratories. An agreed approach for the implementation of metrological traceability to the International System of Units (SI) of serum albumin measurements is … Read more
The (mis)use of artificial intelligence in laboratory medicine; the good, the bad and the uglyMarc H M Thelenon August 22, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1335. Online ahead of print. NO ABSTRACT PMID:42631445 | DOI:10.1515/cclm-2026-1335
Sample volume management: the role of the clinical laboratory in minimizing diagnostic blood lossAna-Maria Šimundićon August 22, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1125. Online ahead of print. ABSTRACT Hospital-acquired anemia is highly prevalent and largely preventable complication of hospitalization, affecting up to 40-74 % of patients and up to 90 % of intensive care units patients. Excessive diagnostic blood loss from routine phlebotomy represents a significant and modifiable contributor, … Read more
Quantification of Proinsulin in Human Plasma by Proteolysis-Aided Peptide Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry
Clin Chem. 2026 Aug 21:hvag105. doi: 10.1093/clinchem/hvag105. Online ahead of print. ABSTRACT BACKGROUND: Plasma proinsulin concentrations are used to investigate hypoglycemia. They have also been proposed as a marker of β-cell function, particularly as a ratio with C-peptide. Immunoassays remain the primary method for measuring proinsulin despite potential limitations. Mass spectrometry-based assays have been described, … Read more
Extending Quality Control Procedures for Multiplexed Clinical Assays
Clin Chem. 2026 Aug 21:hvag100. doi: 10.1093/clinchem/hvag100. Online ahead of print. ABSTRACT BACKGROUND: Multiplexed assays, which simultaneously measure many analytes from a single sample, have become increasingly significant for laboratory diagnosis. Many multiplexed assays with application to clinical diagnosis consist of analyte measurements that can fail individually. In these cases, traditional statistical quantitative quality control … Read more
Serum neurofilament light chain as a biomarker of inflammatory activity in relapsing-remitting multiple sclerosis: a real-world longitudinal cohort studySilvia de Las Heras Flórezon August 21, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0944. Online ahead of print. ABSTRACT OBJECTIVES: Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudinal monitoring. The reference … Read more
Diagnostic performance of nanopore sequencing technology for detecting thalassemia and hemoglobinopathyMoe Theingion August 20, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0783. Online ahead of print. ABSTRACT OBJECTIVES: Thalassemia and hemoglobinopathies are significant genetic disorders in Thailand. Routine diagnostic methods including complete blood count (CBC), hemoglobin (Hb) analysis, and targeted PCR, are effective for detecting common mutations but limited sensitivity for rare and unstable variants, and complex genotypes. … Read more
Interpretive Challenges in Electrophoretic and Mass Spectrometric Methods for Monoclonal Gammopathy Detection in Patients with Cold Agglutinin Disease
Clin Chem. 2026 Aug 20:hvag106. doi: 10.1093/clinchem/hvag106. Online ahead of print. NO ABSTRACT PMID:42621683 | DOI:10.1093/clinchem/hvag106