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Fish-shaped erythrocytes and pincer cells co-occur in distinct hematological disorders and are associated with anemia severityAnna Lena Lembeckon July 6, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 7. doi: 10.1515/cclm-2026-0957. Online ahead of print. ABSTRACT OBJECTIVES: Red blood cell (RBC) morphology in peripheral blood smears (PBS) remains essential for the differential diagnosis of anemia and other hematologic disorders. As yet unclassified poikilocytes, fish-shaped RBCs and pincer (mushroom-shaped) cells are rarely observed but have been described as … Read more

Artificial general intelligence and the clinical laboratory: a paradigm shift toward Lab 2.0Koichiro Yujion July 5, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0789. Online ahead of print. ABSTRACT Clinical laboratory medicine faces converging structural pressures: workforce shortages, growing data complexity, and rapid advances in artificial intelligence (AI). Some prominent developers, including Demis Hassabis of Google DeepMind, have projected the arrival of artificial general intelligence (AGI) around 2030; such timelines … Read more

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research

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Clin Chem. 2026 Jul 4:hvag078. doi: 10.1093/clinchem/hvag078. Online ahead of print. ABSTRACT BACKGROUND: The quantification of plasma glucagon and oxyntomodulin is important in the assessment of α-cell function, which is impaired in patients with diabetes. We aimed to transfer between laboratories a novel assay that uses liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the sensitive and … Read more

Addressing property and unit discordance in laboratory interoperability: the role of NPU as a governance layerKuenyoul Parkon July 4, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0743. Online ahead of print. ABSTRACT OBJECTIVES: Unified Code for Units of Measure (UCUM) encodes syntax without prescribing which unit should be used. The Nomenclature for Properties and Units (NPU) terminology, developed by IFCC and IUPAC, specifies both the kind-of-quantity (e.g., mass concentration or substance concentration) and … Read more

Ethical evaluation of reflex and reflective testing in conformity with ISO 15189:2022 at the value-based laboratory medicine eraGulsen Yilmazon July 3, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0661. Online ahead of print. ABSTRACT OBJECTIVES: The objective of this study is to evaluate the ethical dimensions of reflex and reflective testing (RRT) within the framework of value-based laboratory medicine and in alignment with ISO 15189:2022. The study aims to highlight the challenges in guiding and … Read more

Glucose-enhanced BISAP score for early prediction of severe acute pancreatitis​Kadir Nıgız Salim Satar Selen Acehan Muge Gulen Sarper Sevdımbas Mehmet Gorur a Ministry of Health Sebinkarahisar State Hospital, Emergency Medicine Clinic, Giresun, Turkeyb Health Sciences University, Adana City Training and Research Hospital, Emergency Medicine Clinic, Adana, Turkeyc Ministry of Health 5 Ocak State Hospital, Emergency Medicine Clinic, Adana, Turkeyon May 11, 2026 at 1:52 am

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Volume 86, Issue 4, JULY 2026, Page 334-343.

Likelihood ratios of quantitative diagnostic test results​Arne Åsberg Gustav Mikkelsen Ann Elisabeth Åsberg Øyvind Skadberg a Department of Medical Biochemistry, Stavanger University Hospital, Stavanger, Norwayb Department of Medical Biochemistry, Trondheim University Hospital, Trondheim, Norwayc Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norwayd Department of pediatrics, Trondheim University Hospital, Trondheim, Norwayon May 14, 2026 at 9:55 am

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Volume 86, Issue 4, JULY 2026, Page 369-373.

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