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Biological Variation of Adrenal-Related Endocrine Biomarkers Used for Investigation of Secondary Hypertension

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Clin Chem. 2026 Aug 17:hvag076. doi: 10.1093/clinchem/hvag076. Online ahead of print. ABSTRACT BACKGROUND: Adrenal-related biomarkers are central in evaluating endocrine causes of secondary hypertension, but their interpretation is influenced by biological variation (BV). In this study, we aimed to estimate the within-subject (CVI) and between-subject (CVG) BV and derive the reference change values (RCVs), the … Read more

Model 1b analytical performance specifications – report on the Prague 2025 workshopAndrea R Horvathon August 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 18. doi: 10.1515/cclm-2026-1024. Online ahead of print. ABSTRACT The main purpose of establishing APS is to ensure that test performance aligns with their specific clinical goals. Analytical performance specifications serve multiple functions: as acceptance criteria to verify that in vitro diagnostic medical devices (IVD MD) meet regulatory and quality … Read more

Evaluating variability in 24-hour urine free cortisol measurements: impact of sample collection errorsÖmer Özcanon August 16, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0410. Online ahead of print. ABSTRACT OBJECTIVES: 24 hour urine free cortisol measurement is widely used for screening Cushing’s syndrome, but its reliability is limited by variability due to inherent biological variation and variation introduced by collection errors. This study aimed to determine the proportion of inaccurately … Read more

Lipoprotein X as a source of analytical and interpretative interference in routine laboratory testingShanshan Liangon August 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0950. Online ahead of print. ABSTRACT Lipoprotein X (LpX) is an abnormal lipoprotein-like particle occurring mainly in cholestasis, lecithin-cholesterol acyltransferase deficiency, post-transplant cholestatic liver dysfunction, hepatic graft-versus-host disease, and selected intravenous lipid emulsion or parenteral nutrition settings. Enrichment in phospholipids and unesterified cholesterol, paucity of cholesteryl esters … Read more

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