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Quantification of Proinsulin in Human Plasma by Proteolysis-Aided Peptide Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry

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Clin Chem. 2026 Aug 21:hvag105. doi: 10.1093/clinchem/hvag105. Online ahead of print. ABSTRACT BACKGROUND: Plasma proinsulin concentrations are used to investigate hypoglycemia. They have also been proposed as a marker of β-cell function, particularly as a ratio with C-peptide. Immunoassays remain the primary method for measuring proinsulin despite potential limitations. Mass spectrometry-based assays have been described, … Read more

Extending Quality Control Procedures for Multiplexed Clinical Assays

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Clin Chem. 2026 Aug 21:hvag100. doi: 10.1093/clinchem/hvag100. Online ahead of print. ABSTRACT BACKGROUND: Multiplexed assays, which simultaneously measure many analytes from a single sample, have become increasingly significant for laboratory diagnosis. Many multiplexed assays with application to clinical diagnosis consist of analyte measurements that can fail individually. In these cases, traditional statistical quantitative quality control … Read more

Serum neurofilament light chain as a biomarker of inflammatory activity in relapsing-remitting multiple sclerosis: a real-world longitudinal cohort studySilvia de Las Heras Flórezon August 21, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0944. Online ahead of print. ABSTRACT OBJECTIVES: Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudinal monitoring. The reference … Read more

Diagnostic performance of nanopore sequencing technology for detecting thalassemia and hemoglobinopathyMoe Theingion August 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0783. Online ahead of print. ABSTRACT OBJECTIVES: Thalassemia and hemoglobinopathies are significant genetic disorders in Thailand. Routine diagnostic methods including complete blood count (CBC), hemoglobin (Hb) analysis, and targeted PCR, are effective for detecting common mutations but limited sensitivity for rare and unstable variants, and complex genotypes. … Read more

Distinguishing Acute Myocardial Infarction from Other Forms of Cardiac Injury with the Cardiac Troponin Long-T ITC Complex and High-Sensitivity Troponin I and T in Patients with Suspected Acute Coronary Syndrome: MERITnI Substudy

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Clin Chem. 2026 Aug 20:hvag098. doi: 10.1093/clinchem/hvag098. Online ahead of print. ABSTRACT BACKGROUND: We determined whether circulating cardiac troponin I-cardiac troponin T-troponin C (ITC) complex containing long-form cardiac troponin T (long-T ITC) complex and ratios of high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) could differentiate myocardial infarction (MI) from chronic and … Read more

Interval-specific likelihood ratios improve interpretation of antiphospholipid antibody testing across different analytical platformsJuan Irure-Venturaon August 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0870. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPL) are essential biomarkers for classification, diagnosis, and risk stratification of antiphospholipid syndrome (APS). Although automated analytical platforms, such as chemiluminescent immunoassay (CLIA), and particle-based multi-analyte technology (PMAT), are increasingly implemented in routine laboratories, uncertainty remains regarding their … Read more

How do pre-barcoded tubes improve preanalytical workflow? A survey studySnežana Jovičićon August 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0836. Online ahead of print. ABSTRACT OBJECTIVES: Preanalytical errors account for approximately 60-70 % of all laboratory errors, with sample misidentification among the most frequent causes of inaccurate and unreliable test results. Pre-barcoded tubes (PBTs) are collection tubes uniquely identified during manufacturing with machine-readable labels, eliminating the … Read more

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