Highly Accurate Sequencing Methods for Low-Frequency Variant Detection

Clin Chem. 2026 Jul 29:hvag074. doi: 10.1093/clinchem/hvag074. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing (NGS), also known as massively parallel sequencing, has become an essential tool across many areas of the life sciences, yet its application to low-frequency variant detection remains constrained by intrinsic error rates and the high cost of ultra-deep sequencing. To … Read more

Automated detection of intravenous fluid contamination using longitudinal routine laboratory data: development and external validation of a multitask learning framework​on July 29, 2026 at 2:06 pm

Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Jordi Tortosa-Carreres, Nahúm Martí-Montoro, Jonnathan Andrés Acevedo-Galvis, Cristel Pascual-Escrivà, Ricardo Alonso-Díaz, Óscar Fuster-Lluch, Laura Sahuquillo-Frias, Begoña Laiz-Marro  

Proposed laboratory diagnostic workflow in the Italian national screening program for type 1 diabetesLucia Babinion July 29, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Jul 30. doi: 10.1515/cclm-2026-0536. Online ahead of print. ABSTRACT Population screening for type 1 diabetes (T1D) using pancreatic islet autoantibodies is increasingly recognized as a promising strategy to reduce diabetic ketoacidosis and identify individuals during the presymptomatic stages of the disease. In Italy, Law 130/2023 and the implementing decree of … Read more

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