ccinfoadmin – Clinical Chemistry INFO

A liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of vancomycin in human serum and plasmaSandra Fleischeron August 11, 2026 at 10:00 am

August 11, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Aug 12. doi: 10.1515/cclm-2026-0509. Online ahead of print. ABSTRACT OBJECTIVES: Vancomycin is a glycopeptide antibiotic used to treat severe Gram-positive infections; its narrow therapeutic window makes therapeutic drug monitoring (TDM) critical. We report the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) candidate reference measurement procedure (RMP) to quantify vancomycin … Read more

Clinical chemistry reference intervals in clinically validated healthy individuals: A large single-center studyon August 11, 2026 at 2:02 pm

August 11, 2026 by ccinfoadmin

Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Rob F.M. Oude Elferink, Shirly A.M. Wübbels, Geert Sloots, Anja Koster, Jan Leendert P. Brouwer

Integrated DIA proteomics of tissue and exudate reveals screening markers for early detection of ulcerative colitis and colorectal canceron August 11, 2026 at 2:02 pm

August 11, 2026 by ccinfoadmin

Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Qian Gong, Jin Wang, Qing Ke, Shuangshuang Du, Sinian Huang, Ting Zhu, Hao Qu, Ran Xu, Jiandong Zhang, Bin Yan, Jinjin Wang

Harmonizing M-protein analysis: an international, multi-center reproducibility study of mass spectrometry and evaluation of concordance to electrophoretic methodsKatie Thorenon August 10, 2026 at 10:00 am

August 10, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0844. Online ahead of print. ABSTRACT OBJECTIVES: Serum M-protein analysis is central to the assessment of monoclonal gammopathies. Quantitation and isotyping are commonly performed by SPE or CZE and IFE or IT, respectively. While these assays are widely used, they are characterized by limited sensitivity and subjective … Read more

Reply to Sorigue and Petriz: TRBC1 flow cytometry retains high sensitivity and a low negative likelihood ratio, whereas rule-in interpretation remains context-dependentPablo Adrian Biaggionion August 10, 2026 at 10:00 am

August 10, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-1221. Online ahead of print. NO ABSTRACT PMID:42573469 | DOI:10.1515/cclm-2026-1221

Internal fluidic system contamination associated with falsely increased magnesium results on a Roche Cobas c303 analyzerRaffick A R Bowenon August 10, 2026 at 10:00 am

August 10, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0946. Online ahead of print. NO ABSTRACT PMID:42573468 | DOI:10.1515/cclm-2026-0946

Therapeutic monoclonal antibodies mimicking paraproteins in immunofixation electrophoresis: migration profiles of 21 commonly used agentsMarie-Léa Kabouon August 10, 2026 at 10:00 am

August 10, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0777. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic monoclonal antibodies (t-mAbs) are increasingly used in oncology, hematology, autoimmune diseases, and inflammatory disorders. Because most of these agents are monoclonal immunoglobulins, they may be detected by serum immunofixation electrophoresis (IFE) and mimic pathological monoclonal proteins. METHODS: We analyzed … Read more

P-homocysteine adjusted for estimated glomerular filtration rateArne Åsbergon August 7, 2026 at 10:00 am

August 7, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Aug 10. doi: 10.1515/cclm-2026-1172. Online ahead of print. NO ABSTRACT PMID:42565393 | DOI:10.1515/cclm-2026-1172

An accessible digital single-molecule sensing platform for plasma P-tau217 quantification in Alzheimer’s disease screeningon August 7, 2026 at 9:57 am

August 7, 2026 by ccinfoadmin

Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Meng Xue, Hongchao Pan, Yana He, Haiyan Li, Hailan Zhou, Keding Cheng, ChuangChuang Xiao, Jie Zhao, Xiaodong Jia, Yan Li, Dequan Liu, Keqiang Yan

Sustainability comparison of three clinical laboratory analytical systems in SpainAntonio Fernández Suárezon August 6, 2026 at 10:00 am

August 6, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0817. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratories face growing demands to balance healthcare needs with cost and resource efficiency. Solutions that optimise space, cut costs, and minimise water use and waste offer a competitive edge. This study compares water consumption, waste generation, and reagent efficiency … Read more