Thiopurine S-methyltransferase (TPMT) activity cutoffs in the Thai population​Pimonpan Jinda, Pimpun Kitpoka, Wimol Thienphopirak, Suwat Chiawchan, Santirhat Prommas, Rattanaporn Sukprasong, Jiratha Rachanakul, Supaporn Wiwattanakul, Orapa Suteerojntrakool, Chansuda Bongsebandhu-phubhakdi, Therdpong Tempark, Sittiphong Hunthai, Apichaya Puangpetch1Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, 26687Mahidol University, Bangkok, Thailand2Division of Blood bank, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, 26687Mahidol University, Bangkok, Thailand3Department of Pathology, Faculty of Medicine, 37693Srinakharinwirot University, Nakornnayok, Thailand4Division of Ambulatory Pediatrics, Department of Pediatrics, Faculty of Medicine, 65103Chulalongkorn University, Bangkok, Thailand5Center of Excellence in Pediatric Nutrition, Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand6Department of Biotechnology, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, Thailandon September 8, 2025 at 12:50 pm

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThiopurine S-methyltransferase (TPMT) is crucial for metabolizing thiopurine drugs. This study aimed to establish the cutoff values for TPMT activity in a cohort of healthy individuals. We defined normal TPMT activity ranges and identified …

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