Journal

Anti-GBM pulmonary-renal syndrome: when the laboratory makes the difference​Carmen Frías Ruizon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Jan 12;7(2):160-162. doi: 10.1515/almed-2025-0099. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Pulmonary-renal syndrome (PRS) is a serious condition characterized by concurrent alveolar hemorrhage and rapidly progressive glomerulonephritis. One of the potential causes of PRS is the presence of anti-glomerular basement membrane (anti-GBM) antibodies, which may induce Goodpasture syndrome, a rare, albeit life-threatening, condition … Read more

High sensitive troponin T elevation in an oncology patient on treatment with Pembrolizumab​Alberto Alcalde Moraleson May 15, 2026 at 10:00 am

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Adv Lab Med. 2025 Nov 25;7(2):156-159. doi: 10.1515/almed-2025-0148. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Troponins are a complex of three proteins that play a key role in the contraction of striated muscles. Currently, cardiac troponins T (cTnT) and I (cTnI) are the best biomarkers for acute myocardial infarction (AMI) diagnostic. CASE PRESENTATION: Immune-mediated toxicity due to … Read more

The evolving role of PSA in prostate cancer screening: revisiting the evidence in the era of personalized medicine​Xavier Filellaon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Jan 28;7(2):81-89. doi: 10.1515/almed-2025-0187. eCollection 2026 Jun. ABSTRACT Prostate-specific antigen (PSA) is a widely available and analytically robust biomarker, but its role in prostate cancer (PCa) screening remains controversial due to concerns regarding limited specificity, overdiagnosis of indolent tumors, and the downstream risk of overtreatment. This review provides a critical analysis … Read more

An algorithm to predict intrathecal IgM synthesis in multiple sclerosis patients: optimizing the use of oligoclonal band testing​Jordi Tortosa-Carrereson May 15, 2026 at 10:00 am

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Adv Lab Med. 2025 Dec 8;7(2):148-152. doi: 10.1515/almed-2025-0098. eCollection 2026 Jun. ABSTRACT OBJECTIVES: We aimed to develop a simple, cost-effective algorithm to predict the presence of oligoclonal IgM bands (OCMB) in patients with multiple sclerosis (MS), using surrogate markers such as the IgM Index (IgMi) and the Free Kappa Light Chains Index (FKLCi), with the … Read more

Carcinocythemia detection in peripheral blood smears: a literature review​Javier Lagunaon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Mar 16;7(2):90-104. doi: 10.1515/almed-2025-0169. eCollection 2026 Jun. ABSTRACT Carcinocythemia, or carcinoma cell leukemia, is a rare but striking manifestation of advanced malignancy in which circulating tumor cells (CTCs) are visible in peripheral blood (PB) smears using conventional staining. It is typically associated with advanced stage disease and poor prognosis. This review … Read more

Pharmacogenetic biomarkers for predicting therapeutic response to JAK inhibitors in rheumatoid arthritis​Chamaida Plasencia-Rodríguezon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Apr 23;7(2):124-131. doi: 10.1515/almed-2025-0180. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease of immune-mediated origin. Janus kinase inhibitors (JAK inhibitors) have expanded therapeutic options in recent years; however, clinical response varies among patients, and no biomarkers are currently available to predict their efficacy. The aim of … Read more

Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction

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Clin Chem. 2026 May 15:hvag030. doi: 10.1093/clinchem/hvag030. Online ahead of print. ABSTRACT BACKGROUND: Sex-specific diagnostic thresholds for high-sensitivity cardiac troponin (hs-cTn) assays are recommended by international guidelines for the diagnosis of myocardial infarction (MI). We assessed the performance of sex-specific single-sample rule-out thresholds for identifying low-risk patients in the emergency department. METHODS: The derivation cohort … Read more

First-trimester free thyroxine as an independent predictor of gestational diabetes mellitus: a retrospective cohort study​Thu T T Doon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Apr 28;7(2):132-139. doi: 10.1515/almed-2026-0007. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Gestational diabetes mellitus (GDM) and thyroid dysfunction are two common endocrine diseases during pregnancy, both of which can adversely affect maternal and fetal health. Numerous studies have shown that abnormalities in thyroid hormones, particularly TSH and FT4, are associated with an increased … Read more

Comparison of capillary and venous hemoglobin determination among school-age children: insights from Zanzibar, Tanzania​Kaunara Azizion May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Apr 15;7(2):140-147. doi: 10.1515/almed-2025-0053. eCollection 2026 Jun. ABSTRACT OBJECTIVES: There is apprehension regarding the agreement between capillary and venous hemoglobin (Hb) concentrations, which may have far-reaching consequences for global anemia prevalence estimates, heavily dependent on capillary Hb data. METHODS: We investigated the discrepancies in Hb concentrations obtained from venous and capillary … Read more

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