A Digital PCR Assay for Fetal Fraction Quantification Using Multiplex SNP and Y Chromosome Detection

Clin Chem. 2026 Feb 26:hvag017. doi: 10.1093/clinchem/hvag017. Online ahead of print. ABSTRACT BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome (chrY), differential methylation, or single-nucleotide polymorphisms (SNPs) face limitations including sex dependency, complex workflows, or the need for parental genotyping. An FF quantification method that … Read more

Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine

Clin Chem. 2026 Feb 26:hvag014. doi: 10.1093/clinchem/hvag014. Online ahead of print. ABSTRACT BACKGROUND: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To ensure patient safety, laboratory professionals must define appropriate analytical requirements for each measurand, including measurement uncertainty, selectivity, traceability, and robustness. Performance specifications should ensure that … Read more

Detection of thyroid hormones T3 and T4 in urine and serum after levothyroxine administration: A pilot study relevant to doping analysis​on February 26, 2026 at 12:46 pm

Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): T. Colpaert, K. Van Uytfanghe, G. T’Sjoen, N. Van Haecke, W. Van Gansbeke, P. Van Renterghem, M. Olijhoek, O. de Hon, G. Coppieters, P. Van Eenoo, K. Deventer  

Establishment of trimester-specific reference intervals for hemostatic and hematologic indices and their associations with adverse pregnancy outcomes​on February 25, 2026 at 11:32 am

Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Huimin Shi, Jiayi Chen, Junwei Liu, Qingxiu Li, Bin Sun, Danwei Zhang, Zhengqin Wu, Haiyan Gao, Wei Li, Wenjuan Liu, Qian Zhang, Yibing Zhu, Haibo Li  

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