Journal

Investigating the effect of icterus interference on a creatinine Roche enzymatic methodology​Kelsey S Spencer, Louise E Duvall6698Portsmouth Hospitals University NHS Trust, Portsmouth, UKon April 12, 2025 at 2:50 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundIt is well established that high bilirubin concentrations can lead to erroneous creatinine results when measured by a Jaffe-based method. However, the effects of bilirubin on enzymatic methods appear less well-defined. The Roche Cobas 8000 …

The effect of inadequate drying of blood spots on newborn screening analyte concentrations​Stuart J Moat, Melissa Levi, Margaret Birch, Nadia Worlock, Chandra Sundas, Lucy Woodcock, Jude Kay, Sikha de Souza, Annabel Rodham1Wales Newborn Screening Laboratory, Department of Medical Biochemistry, Immunology and Toxicology, University Hospital of Wales, Cardiff, UK2Screening Division, 9476Public Health Wales, Cardiff, UKon April 12, 2025 at 2:51 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundA critical pre-analytical phase of newborn screening (NBS) testing involves the drying of blood applied to the blood collection devices to form the dried blood spots (DBS). Guidance states that blood applied should be air-dried for a minimum of …

Pseudohyperphosphatemia induced by endogenous lipoproteins: New elements supporting an interference with ammonium phosphomolybdate-based methods​Charles R. Lefèvre, Felipe Le Divenah, Bastien Paterek, Kubra Cankaya, Martine Ropert-Bouchet, Emmanuelle Letourneux, Maxime Pawlowski, Nicolas Collet, Claude Bendavid1Clinical Biochemistry and Toxicology Laboratory, Rennes University Hospital Centre, Rennes, France2INSERM, INRAE, Univ Rennes, Institut NUMECAN, Rennes, Franceon April 30, 2025 at 3:39 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundInorganic phosphate (Pi) is a crucial electrolyte for maintaining homeostasis. Most methods measure Pi using ammonium phosphomolybdate under highly acidic conditions. Phospholipid-rich substances, such as liposomal amphotericin B, have been …

Effect of pH on stability and solid phase extraction of urinary free metadrenaline measurement by liquid chromatography tandem mass spectrometry​Lindsay McDonald, Craig Livie, Karen Smith, Susan JohnstonDepartment of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow, UKon April 30, 2025 at 3:36 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundMeasurement of urine free metadrenalines offers potential diagnostic and practical advantages over urinary fractionated metadrenalines in detection of phaeochromocytoma and paraganglioma, including sample collection without acid preservative. …

The early diagnostic value of C-reactive protein (CRP) in deep sternal wound infection after cardiac surgery​Shanshan Jia, Jie Zhao, Jixun Zhang, Duyin Jiang1The Second Clinical College of Shandong University, Jinan, China2Department of Plastic and Burns Surgery, 531675The Second Hospital of Shandong University, Jinan, China3Department of Emergency Medicine Center, 531675The Second Hospital of Shandong University, Jinan, Chinaon June 11, 2025 at 9:32 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThis study aimed to evaluate the early diagnostic value of C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), neutrophil ratio (NEUT%), and neutrophil-to-lymphocyte ratio (NLR) in patients with deep sternal wound …

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