Journal

Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1100. Online ahead of print. ABSTRACT OBJECTIVES: Clinical interpretation of ferritin is hindered by between-assay differences, persisting despite the introduction of different generations of WHO standard. To aid harmonisation efforts, this study investigates the commutability of External Quality Assessment (EQA) materials, proof-of-concept reference materials (cRMs), and the … Read more

Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-0893. Online ahead of print. ABSTRACT OBJECTIVES: Accurate quantification of M-proteins is important for clinical management of monoclonal gammopathies. Reliable assessment of trueness on M-protein quantification in External Quality Assessment (EQA) schemes is difficult due to the lack of reference methods and materials for target value assignment. … Read more

Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1099. Online ahead of print. ABSTRACT OBJECTIVES: Using HbA1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA1c concentrations and components of analytical uncertainty into clinically interpretable … Read more

Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-0910. Online ahead of print. ABSTRACT INTRODUCTION: Laboratory medicine relies on multiple metrological, analytical, interpretative, and clinical frameworks. Although each addresses a specific question, the relationships linking measurement, interpretation, clinical translation, and action remain incompletely articulated. This fragmentation may encourage inferential overreach, whereby evidence is used to … Read more

Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1113. Online ahead of print. ABSTRACT Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, therapeutic decision-making, and longitudinal disease monitoring. To effectively support clinical decision-making, … Read more

Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1262. Online ahead of print. ABSTRACT Lipoprotein(a) [Lp(a)] is a causal, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. New guidelines recommend testing everyone at least once in a lifetime, and with new drugs specifically targeting Lp(a) on the horizon, accurate measurement remains … Read more