Journal

Performance validation and clinical utility of a smartphone-based colorimetric system for differentiating exudative and transudative pleural effusions and ascites via total protein quantification​Dandan Liang, Yonghua Zhao, Yufei Guo, Ziqi Li, Zehua Yang174648Academy of Medical Sciences, Shanxi Medical University, Jinzhong, Shanxi, China2The First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China3Department of Laboratory, 74648The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, Chinaon May 13, 2026 at 2:24 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundTotal protein (TP) is a key indicator to differentiate between pleural effusion (PE) and ascites as exudate or transudate. Rapid quantification of TP can provide more accurate clinical treatment.ObjectiveThis study developed a smartphone-based …

Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma

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Clin Chem. 2026 May 21:hvag036. doi: 10.1093/clinchem/hvag036. Online ahead of print. ABSTRACT BACKGROUND: The early diagnosis of primary CNS lymphoma (PCNSL) is challenging due to its rapid progression and the lack of reliable noninvasive biomarkers. We aimed to identify robust fluid-based biomarkers for PCNSL, with a focus on primary vitreoretinal lymphoma (PVRL), which is a … Read more

Long-read Oxford Nanopore sequencing enables rapid, cost-effective, and comprehensive TTR genetic testing for hereditary transthyretin amyloidosisGilles Millaton May 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 20. doi: 10.1515/cclm-2026-0553. Online ahead of print. ABSTRACT OBJECTIVES: Hereditary transthyretin amyloidosis (ATTRv) is a rare autosomal dominant disorder caused by pathogenic variants in the TTR gene, with marked clinical heterogeneity and frequent underdiagnosis. Genetic confirmation is essential for patient management but is traditionally based on Sanger sequencing or … Read more

Quantitative analysis and clinical evaluation of 20- and 22-kDa growth hormone isoforms in somatotroph adenoma using immunocapture coupled with LC-MS/MSYao Huon May 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 19. doi: 10.1515/cclm-2026-0382. Online ahead of print. ABSTRACT OBJECTIVES: The 20- and 22-kDa isoforms of growth hormone 1 (GH1) play potentially distinct physiological and pathological roles, but their structural similarity makes quantification challenging. Conventional immunoassays lack sufficient specificity, highlighting the need for more precise analytical methods. METHODS: We developed … Read more

EurA1c: a review of 9 years performance of up to 5120 laboratories in 29 country and 26 manufacturer groups according to current and proposed criteria of the IFCC Model for Quality Targets in relation to the use of HbA1c for monitoring and diagnosis of diabetesEurA1c Trial Groupon May 18, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 19. doi: 10.1515/cclm-2026-0276. Online ahead of print. ABSTRACT OBJECTIVES: A major objective of the IFCC Committee for Education in the Use of Biomarkers in Diabetes is to monitor the success of global standardization of HbA1c through benchmark evaluation of the performance by country and manufacturer. METHODS: From 2016 to … Read more

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