Journal

Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions

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Clin Chem. 2026 Mar 7:hvag010. doi: 10.1093/clinchem/hvag010. Online ahead of print. ABSTRACT BACKGROUND: Accurate descriptions of human genomic variants are crucial for gene-disease association, discovery, and clinical diagnosis. Although standardized genomic nomenclature, expertly curated and promulgated by the Human Genome Variation Society and the International Standing Committee on Human Cytogenomic Nomenclature, is strongly encouraged in … Read more

A Culture-Free Lipidomics-Based Screening Test for Uropathogens

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Clin Chem. 2026 Mar 5;72(3):381-389. doi: 10.1093/clinchem/hvaf164. ABSTRACT BACKGROUND: A rapid culture-free method is needed to improve diagnostic efficiency and guide timely antimicrobial therapy for urinary tract infections (UTIs). Previously, we utilized the lipidomics-based fast lipid analysis technique (FLAT) to screen for uropathogens by identifying distinctive microbial membrane lipid profiles, specifically lipid A in gram-negative … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasmaMarie Kubicovaon March 9, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 10. doi: 10.1515/cclm-2025-1366. Online ahead of print. ABSTRACT OBJECTIVES: The quantification of linezolid in serum and plasma matrices is crucial for therapeutic drug monitoring and pharmacokinetic studies. A reference measurement procedure (RMP) was developed and validated to provide accurate, precise, and reliable measurements, fit for its intended use while … Read more

Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care settingPaul Collinsonon March 5, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2026-0210. Online ahead of print. ABSTRACT A challenge in the implementation of rapid risk-stratification algorithms for patients with suspected acute coronary syndrome is the turnaround time for cardiac troponin (cTn) from blood sampling to reporting of results. Measurement of cTn in whole blood using point of care … Read more

Rare ANA patterns and their clinical correlates: a retrospective large-cohort studyRenren Ouyangon March 5, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2025-1493. Online ahead of print. ABSTRACT OBJECTIVES: To determine the prevalence and clinical associations of rare HEp 2 indirect immunofluorescence ANA patterns and to evaluate their relationships with disease categories, ANA titers, and expression form. METHODS: We retrospectively analyzed 366,524 ANA tests performed between 2018 and 2024 … Read more

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