In-vitro verification of tolerance limits for biotin interference of routine biochemistry and immunology assays​Kirsty Swallow, Graeme Wild, Ravishankar SargurImmunology Department and Protein Reference Unit, Northern General Hospital, Sheffield, UKon March 25, 2026 at 1:17 am

Annals of Clinical Biochemistry, Ahead of Print. BackgroundBiotin is commonly used in many commercial assays. It is known that exogenous biotin can interfere with these tests, however, not all manufacturers have issued warnings or reassurances. Interference can lead to increased or decreased …

High-throughput quantification of tacrolimus in whole blood by acoustic ejection mass spectrometry: analytical validation and comparative assessment against conventional LC-MS/MS for therapeutic drug monitoring​on March 31, 2026 at 6:16 am

Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Xin-Yu Wu, Xiao-Kang Fu, Ao Li, Wei Zhang, Han-Peng Jiang, Na An, Quan-Fei Zhu, Shao-Ting Wang, Yu-Qi Feng  

Thyroid hormone profile and biological variation in a population of athletes during an entire sport season​on March 31, 2026 at 6:16 am

Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Isabel Moreno-Parro, Jorge Díaz-Garzón, Berta Sufrate-Vergara, Aasne K. Aarsand, Sverre Sandberg, Anna Carobene, Outi Itkonen, William Bartlett, Abdurrahman Coskun, Niels Jonker, Pilar Fernández-Calle, on behalf of theEuropean Federation of Clinical Chemistry and Biological Variation Committee  

Current and Future Indication for Testing and Use of Cardiac Troponin in Children

Clin Chem. 2026 Mar 27:hvag021. doi: 10.1093/clinchem/hvag021. Online ahead of print. ABSTRACT BACKGROUND: The clinical use and interpretation of cardiac troponins (cTn) in pediatric patients is heterogeneous. CONTENT: This review is based on an appraisal and synthesis of the available literature and discussions between International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical … Read more

Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers

Clin Chem. 2026 Mar 27:hvag018. doi: 10.1093/clinchem/hvag018. Online ahead of print. ABSTRACT BACKGROUND: Bisulfite conversion remains the gold standard method for DNA methylation analysis but has known limitations. Enzymatic conversion has recently been developed and overcomes some of these pitfalls. This study compared both methods by measuring known colorectal cancer (CRC) methylated biomarkers in colorectal … Read more

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