Highly Accurate Sequencing Methods for Low-Frequency Variant Detection

Clin Chem. 2026 Jul 29:hvag074. doi: 10.1093/clinchem/hvag074. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing (NGS), also known as massively parallel sequencing, has become an essential tool across many areas of the life sciences, yet its application to low-frequency variant detection remains constrained by intrinsic error rates and the high cost of ultra-deep sequencing. To … Read more

Automated detection of intravenous fluid contamination using longitudinal routine laboratory data: development and external validation of a multitask learning framework​on July 29, 2026 at 2:06 pm

Publication date: 15 February 2027 Source: Clinica Chimica Acta, Volume 593 Author(s): Jordi Tortosa-Carreres, Nahúm Martí-Montoro, Jonnathan Andrés Acevedo-Galvis, Cristel Pascual-Escrivà, Ricardo Alonso-Díaz, Óscar Fuster-Lluch, Laura Sahuquillo-Frias, Begoña Laiz-Marro  

Proposed laboratory diagnostic workflow in the Italian national screening program for type 1 diabetesLucia Babinion July 29, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Jul 30. doi: 10.1515/cclm-2026-0536. Online ahead of print. ABSTRACT Population screening for type 1 diabetes (T1D) using pancreatic islet autoantibodies is increasingly recognized as a promising strategy to reduce diabetic ketoacidosis and identify individuals during the presymptomatic stages of the disease. In Italy, Law 130/2023 and the implementing decree of … Read more

The severity of harm score database: an evidence-based foundation for laboratory test risk analysisHikmet Can Çubukçuon July 28, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0875. Online ahead of print. ABSTRACT BACKGROUND: Patient risk management has become central to clinical laboratory quality standards, including the Clinical and Laboratory Standards Institute (CLSI) EP23 2nd edition (CLSI EP23-ED2), International Organization for Standardization (ISO) 15189:2022, ISO 22367:2026, and ISO 14971:2019. A key component of risk … Read more

Performance validation of mass spectrometry for detecting urinary Bence Jones protein and evaluation of its clinical application in multiple myeloma and amyloidosisYu Chenon July 28, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0469. Online ahead of print. ABSTRACT OBJECTIVES: Traditional urine immunofixation electrophoresis (uIFE) is cumbersome, has limited sensitivity, and is subjectively interpreted. This is especially problematic in renal impairment where accumulation of polyclonal free light chains may pseudonormalize the serum free light chain (sFLC) ratio, compromising its reliability … Read more

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