Journal

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0408. Online ahead of print. ABSTRACT OBJECTIVES: Point-of-care (POC) International Normalised Ratio (INR) testing provides rapid anticoagulation monitoring. Still, it is susceptible to systematic bias, particularly at supratherapeutic levels, which can lead to inappropriate warfarin dose adjustments and increased thrombotic risk. This study evaluated bias trends between … Read more

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2025-0872. Online ahead of print. ABSTRACT OBJECTIVES: Calibration is a cornerstone of clinical chemistry test results and maintaining an in-house LDT requires periodic renewal of calibrators. Here we present the introduction of a new set of native human serum calibrators, using different curve fitting approaches for long-term … Read more

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0489. Online ahead of print. ABSTRACT OBJECTIVES: In polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, when monoclonal plasma cell proliferation is absent, it is considered ‘non-secretory POEMS syndrome’. We aimed to study whether M-protein was detectable by mass spectrometry (MS) in previously non-secretory POEMS syndrome. … Read more

Clin Chem Lab Med. 2026 Jul 9. doi: 10.1515/cclm-2026-0444. Online ahead of print. ABSTRACT A widely accepted approach to setting Analytical Performance Specifications (APS) in laboratory medicine is the Milan models. The Milan Model 1b is an approach in which APS are developed based on patient classification or clinical decision-making, noting that these factors are … Read more