Clinical Chemistry

Laboratory Monitoring in Transgender and Gender-Diverse Individuals

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Clin Chem. 2025 Mar 3;71(3):358-377. doi: 10.1093/clinchem/hvaf001. ABSTRACT BACKGROUND: Increasing numbers of transgender and gender-diverse individuals are seeking initiation of gender-affirming hormone therapy. This aligns an individual’s physical characteristics with their gender identity and improves psychological outcomes. Physical changes, including changes to muscle mass and body fat redistribution, can alter sex-specific laboratory reference ranges. CONTENT: … Read more

Enrichment of Microbial DNA in Plasma to Improve Pathogen Detection in Sepsis: A Pilot Study

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Clin Chem. 2025 Mar 11:hvaf011. doi: 10.1093/clinchem/hvaf011. Online ahead of print. ABSTRACT BACKGROUND: Diagnosis of sepsis and timely identification of pathogens in critically ill patients remains challenging. Plasma metagenomic sequencing to detect microbial cell-free DNA (mDNA) has shown promise, but low abundance of mDNA in plasma limits sensitivity and necessitates high sequencing depth. mDNA is … Read more

Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants by an Improved Full-Length ABO Haplotype Sequencing

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Clin Chem. 2025 Mar 6:hvaf015. doi: 10.1093/clinchem/hvaf015. Online ahead of print. ABSTRACT BACKGROUND: Full-length ABO haplotype sequencing is crucial for accurate genotyping, reference gene annotation, and molecular mechanism analysis of its variants. However, there is currently a deficiency of comprehensive annotation for full-length ABO haplotypes, spanning from the 5′ untranslated region (UTR) to the 3′ … Read more

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