Clinical Chemistry and Laboratory Medicine

Targeted proteomics of serum IGF-I, -II, IGFBP-2, -3, -4, -5, -6 and ALSJakob Albrethsenon March 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 24. doi: 10.1515/cclm-2024-1428. Online ahead of print. ABSTRACT OBJECTIVES: The insulin-like growth factors (IGFs) regulate growth in humans. IGF-I and IGF binding protein (IGFBP)-3 are biomarkers in children with growth disorders. We investigate a targeted proteomics method for absolute quantitation of eight IGF protein family members in human serum, … Read more

Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?Claudia Grossion March 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 21. doi: 10.1515/cclm-2025-0032. Online ahead of print. ABSTRACT OBJECTIVES: The Certified Reference Material (CRM) ERM®-DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated CRM’s ability to represent the heterogeneity of APS patient anti-β2GPI antibodies and … Read more

Reliable detection of sex chromosome abnormalities by quantitative fluorescence polymerase chain reactionCamilla Mains Balleon March 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1400. Online ahead of print. ABSTRACT OBJECTIVES: Many patients with sex chromosome abnormalities (SCAs) are diagnosed late in life or remain undiagnosed, leading to delayed or inadequate medical intervention and care. This study aimed to develop a reliable, rapid and cost-effective test for identifying SCAs using a … Read more

Use of the BIOGROUP® French laboratories database to conduct CKD observational studies: a pilot EPI-CKD1 studyClaire Visseauxon March 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 20. doi: 10.1515/cclm-2024-1399. Online ahead of print. ABSTRACT OBJECTIVES: Medical biology is essential for diagnosing and monitoring cardio-reno-metabolic diseases. The EPI-CKD1 study utilizes data from Biogroup® French laboratories to examine the burden of chronic kidney disease (CKD) and the effect of heart failure, and diabetes in an outpatient setting … Read more

Novel protocol for metabolomics data normalization and biomarker discovery in human tearsJoan Serrano-Marínon March 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 19. doi: 10.1515/cclm-2024-1360. Online ahead of print. ABSTRACT OBJECTIVES: Human tear analysis holds promise for biomarker discovery, but its clinical utility is hindered by the lack of standardized reference values, limiting interindividual comparisons. This study aimed at developing a protocol for normalizing metabolomic data from human tears, enhancing its … Read more

Artificial base mismatches-mediated PCR (ABM-PCR) for detecting clinically relevant single-base mutationsCia-Hin Lauon March 15, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Mar 17. doi: 10.1515/cclm-2024-0962. Online ahead of print. ABSTRACT OBJECTIVES: Detecting point mutations with high sensitivity and specificity can be technically very challenging, but it is crucial for early diagnosis and effective drug treatment of cancers. To enable ultrasensitive and ultraspecific detection of single-base mutations in simple and economical ways, … Read more

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