Clinical Chemistry and Laboratory Medicine

Pre-analytical phase errors constitute the vast majority of errors in clinical laboratory testingYanchun Linon May 1, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0190. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratory errors pose a threat to patient safety and previous studies have demonstrated that pre-analytical error is the most common error type. Our study aimed to determine the types and frequency of errors occurring in clinical laboratory testing in … Read more

Promising protein biomarkers for early gastric cancer: clinical performance of combined detectionWeifeng Shenon April 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2024-1510. Online ahead of print. ABSTRACT OBJECTIVES: In the early stage of gastric cancer (GC), identifying cancer-specific biomarkers is a key step in the disease screening process. This study aims to explore the clinical value of five novel protein biomarkers and their combination (5 MP) for GC … Read more

Beyond the Hydrashift assay: the utility of isoelectric focusing for therapeutic antibody and paraprotein detectionRieke Reiteron April 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0352. Online ahead of print. ABSTRACT OBJECTIVES: In serum immunofixation electrophoresis, therapeutic monoclonal antibodies (tmAbs) can be misinterpreted as paraproteins. Strategies to circumvent these interferences include the use of anti-tmAb antibodies, which led to the development of the Hydrashift assay. However, this assay is exclusively available for … Read more

Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practicesWeiyan Zhouon April 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0186. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) is critical for optimizing antipsychotic therapy, yet inter-laboratory comparability in China remains poor. Unstandardized practices risk suboptimal dosing and adverse effects, highlighting the need for standardization. This study evaluated TDM practices for six antipsychotics (olanzapine, clozapine, … Read more

IFCC recommendations for internal quality control practice: a missed opportunityHikmet Can Çubukçuon April 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 28. doi: 10.1515/cclm-2025-0486. Online ahead of print. ABSTRACT The IFCC Task Force on Global Lab Quality (TF-GLQ) has recently released a new guidance for internal quality control (IQC) practice through an approach translating the general principles as stated in the ISO 15189:2022 standard to a series of practical recommendations. … Read more

A physio-chemical mathematical model of the effects of blood analysis delay on acid-base, metabolite and electrolyte status: evaluation in blood from critical care patientsBahareh Nevirianon April 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2024 Dec 31;63(6):1139-1152. doi: 10.1515/cclm-2024-1350. Print 2025 May 26. ABSTRACT OBJECTIVES: Measurements of acid-base status are performed quickly after blood sampling avoiding errors. This necessitates rapid sample transport which can be problematic. This study measures blood sampled in critically ill patients over 180 min and proposes a mathematical physio-chemical model to … Read more

Potential coeliac disease in children: a single-center experienceLuisa Lonoceon April 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 25. doi: 10.1515/cclm-2025-0098. Online ahead of print. ABSTRACT OBJECTIVES: Potential coeliac disease (PCD) is defined by the presence of positive CD-specific autoantibodies with a normal/extremely mildly damaged intestinal mucosa. This study sought to examine the progression of PCD in children maintaining a gluten-containing diet and to identify risk factors … Read more

Development of commutable candidate certified reference materials from protein solutions: concept and application to human insulinShiwen Luoon April 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0329. Online ahead of print. ABSTRACT OBJECTIVES: To explore the reasons behind the lack of commutability in protein solution reference materials (RMs) and seeks to eliminate these factors in order to develop commutable reference materials, using human insulin (hINS) as example, to meet the growing demand for … Read more

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