Clinical Chemistry and Laboratory Medicine

Understanding the circulating forms of cardiac troponin: insights for clinical practicePanpan Lvon May 29, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2024-1236. Online ahead of print. ABSTRACT Ischemic heart disease remains the leading cause of death globally, with acute coronary syndrome (ACS) being the main reason for emergency hospital admissions and thus representing a significant health care issue worldwide. Cardiac troponin I (cTnI) and cardiac troponin T (cTnT) … Read more

Effect of long-term frozen storage on stability of kappa free light chain indexMartin Schmidaueron May 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 8. doi: 10.1515/cclm-2025-0125. Online ahead of print. ABSTRACT OBJECTIVES: To investigate whether frozen storage duration influences κ-FLC index. METHODS: CSF and serum samples of patients with multiple sclerosis collected for routine diagnostic purposes had been stored at -20 °C. κ-FLC and albumin concentrations were measured at two different timepoints, … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 17β-estradiol in human serum and plasmaMyriam Otton May 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 26. doi: 10.1515/cclm-2024-1255. Online ahead of print. ABSTRACT OBJECTIVES: A new candidate isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based reference measurement procedure (RMP) has been developed for the accurate and precise quantification of 17β-estradiol (E2) in human serum and plasma covering a measurement range from 0.400 to 5,000 pg/mL (1.47-18,357 … Read more

Candidate reference measurement procedure based on isotope dilution-two dimensional-liquid chromatography-tandem mass spectrometry for the quantification of androstenedione in human serum and plasmaMyriam Otton May 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 23. doi: 10.1515/cclm-2024-1135. Online ahead of print. ABSTRACT OBJECTIVES: Androstenedione (ASD) is a biomarker used in the diagnosis of hyperandrogenism and adrenal hyperplasia. Therefore, accurate measurement of serum ASD is pivotal in clinical settings. We aimed to develop a novel highly selective reference measurement procedure (RMP) based on isotope … Read more

Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approachAbdulrazzaq Alherakyon May 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0189. Online ahead of print. ABSTRACT OBJECTIVES: Histamine, mainly produced in mast cells (MC), plays a key role in allergy and inflammation. Measuring its urinary metabolites, N-methylhistamine (NMH) and 1-methyl-4-imidazoleacetic acid (MIMA), is essential in assessing histamine-related pathologies. Patients with concurrent systemic mastocytosis (SM) and hereditary alpha … Read more

A cost-effective assessment for the combination of indirect immunofluorescence and solid-phase assay in ANA-screeningNicoletta Galloon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0170. Online ahead of print. ABSTRACT OBJECTIVES: Anti-nuclear antibodies (ANA) testing on indirect immunofluorescence (IIF) has been for a long time the gold standard assay in the diagnosis of rheumatic diseases; more recently different solid phase assays (SPA) have been recommended to increase specificity of positive results. … Read more

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