Clinical Chemistry and Laboratory Medicine

Mitochondrial DNA copy number in leukocytes predicts long-term survival in prostate cancerTanja Langsenlehneron April 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 16. doi: 10.1515/cclm-2025-1464. Online ahead of print. ABSTRACT OBJECTIVES: Low mitochondrial DNA copy number (mtCN) in leukocytes is a predictor of all-cause mortality, independent of age and sex. For malignant diseases, results about the prognostic value of leukocyte mtCN have been conflicting. Aim of the present study was to … Read more

Improving clinical interpretation of serum alpha-fetoprotein in children: using continuous and discrete reference intervalsDien Minh Tranon April 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0262. Online ahead of print. ABSTRACT OBJECTIVES: To establish discrete and continuous age-specific reference intervals for serum alpha-fetoprotein in children and to evaluate whether continuous modeling improves interpretation during early infancy, when concentrations decline rapidly. METHODS: In this prospective, cross-sectional study, serum alpha-fetoprotein was measured in 3,680 … Read more

Salivary testosterone reference intervals for adult women and menMirjam Kruijton April 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0144. Online ahead of print. ABSTRACT OBJECTIVES: Testosterone is increasingly being measured in saliva due to the ease of collection, which puts a lower burden on patients and facilitates measurement in clinical and behavioral studies. Although the robustness of measuring testosterone in saliva using immunoassays has been … Read more

Feasibility of improving sLe(a)/CA 19-9 harmonization by recalibration: a simulation study using three EQA programsHuub H van Rossumon April 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0155. Online ahead of print. ABSTRACT OBJECTIVES: The CA 19-9 tumor marker measures the sialylated Lewis a blood group antigen (sLe(a)) expressed on circulating proteins. CA 19-9 is primarily used to monitor pancreatic and gastrointestinal cancers. Studies have demonstrated the lack of comparability of CA 19-9 assays. … Read more

A simplified multitarget stool test for colorectal cancer and advanced precancerous lesion detectionShuizhi Xuon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0236. Online ahead of print. ABSTRACT OBJECTIVES: Multitarget stool tests are approved for colorectal cancer (CRC) screening. Here we developed a multitarget stool test based on the fecal immunochemical test (FIT) and two (NDRG4 and SDC2) DNA methylation markers with a simple calling algorithm. METHODS: FIT, quantitative … Read more

Analytical and clinical performance of the Flash10 molecular point-of-care system for detection of influenza A and B virusesSheng Zengon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0093. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the analytical performance and clinical workflow efficiency of the Flash10 molecular point-of-care testing (POCT) system for the detection of influenza A (FluA) and influenza B (FluB) viruses. METHODS: Throat swab specimens from 178 individuals presenting with influenza-like symptoms … Read more

The prevalence and etiology of macro-growth hormone (GH)Hiroshi Ohnoon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0043. Online ahead of print. ABSTRACT OBJECTIVES: Several macro-hormones have been reported to date. Among them, macroprolactinemia is a common cause of hyperprolactinemia. Growth hormone (GH) and prolactin (PRL) are anterior pituitary hormones related by structure and function. The aim of this study was to clarify the … Read more

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