Clinical Chemistry and Laboratory Medicine

Ethical evaluation of reflex and reflective testing in conformity with ISO 15189:2022 at the value-based laboratory medicine eraGulsen Yilmazon July 3, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0661. Online ahead of print. ABSTRACT OBJECTIVES: The objective of this study is to evaluate the ethical dimensions of reflex and reflective testing (RRT) within the framework of value-based laboratory medicine and in alignment with ISO 15189:2022. The study aims to highlight the challenges in guiding and … Read more

Emerging blood-based diagnostic strategies for tuberculosisChunlin Yueon July 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 2. doi: 10.1515/cclm-2026-0123. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global public health challenge. Rapid and accurate diagnostic methods are critical for effective TB control. In recent years, serological diagnosis has attracted growing attention with the continuous identification of novel biomarkers, owing … Read more

Homocitrulline and 3-year mortality in older hospitalised adults: an exploratory studyPeter Noujaimon July 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 2. doi: 10.1515/cclm-2026-0173. Online ahead of print. ABSTRACT OBJECTIVES: Reliable biomarkers may allow early risk stratification for mortality in older adults. Post-translational modification-derived products (PTMDPs), such as homocitrulline, and the tissue accumulation of advanced glycation end products (AGEs), measured by skin autofluorescence, have been suggested as potential biomarkers of … Read more

Impact of age partitioning on classification discordance in pediatric ferritin reference intervalsDien Minh Tranon June 30, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0785. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate how alternative age-partitioning strategies affect result classification using discrete pediatric ferritin reference intervals (RIs). METHODS: In a prospective cohort of 3,322 apparently healthy individuals aged birth to <19 years, serum ferritin was measured on the Cobas Pro platform. … Read more

National implementation of LOINC: translation methodology and experience from the Polish laboratory terminology standardization projectRafał Świechowskion June 30, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0504. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to present the results of translating the LOINC standard into Polish, summarize key methodological lessons, and outline the current stage of LOINC implementation in Poland. METHODS: Three editions of the LOINC dictionary translation process were conducted using … Read more

Harmonization of measurement units: mission impossible or ethical imperative?Mario Plebanion June 30, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0934. Online ahead of print. ABSTRACT Harmonization initiatives in laboratory medicine have a long history. Nevertheless, despite substantial efforts by international federations, scientific societies, and expert working groups, their implementation and widespread adoption remain incomplete, with many initiatives still at a relatively early stage of development. More … Read more

Analysis of albumin-to-creatinine ratio on automated analysers using a microsampling card (Capitainer DIP70 card) for the collection of urineJohan Olaussonon June 29, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 30. doi: 10.1515/cclm-2026-0034. Online ahead of print. ABSTRACT OBJECTIVES: Albuminuria is a key biomarker of kidney damage, yet preanalytical challenges with conventional liquid urine testing, limiting its utility for decentralized and large-scale screening. This study evaluated the analytical performance of a novel dried urine spot (DUS) device, for measuring … Read more

The effect of Sebia’s CZE IFCC-converted results on carbohydrate-deficient transferrin (CDT) interpretation in driver’s license assessmentsNathan Debunneon June 25, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 26. doi: 10.1515/cclm-2026-0346. Online ahead of print. ABSTRACT OBJECTIVES: Carbohydrate-deficient transferrin (CDT) is a specific biomarker for chronic excessive alcohol consumption. The IFCC Working Group on CDT Standardization recommends 2-sialo-transferrin (2-sialo-Tf) as the sole measurand, with a decision threshold of 2.0 % CDTIFCC using HPLC. This study evaluates the … Read more

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