Clinical Chemistry and Laboratory Medicine

Digital and computational morphology in hematology: current platforms, clinical evidence, and future requirementsGina Zinion September 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1265. Online ahead of print. ABSTRACT INTRODUCTION: Morphologic examination of peripheral blood and bone marrow remains central to the diagnosis and classification of hematologic disorders. Conventional optical microscopy, however, is labor-intensive, dependent on operator expertise, and affected by interobserver variability. Digital morphology has developed from automated image … Read more

Alternative futures for laboratory medicine in 2050: scenarios and signposts for diagnostic capability contractionKoichiro Yujion September 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1377. Online ahead of print. ABSTRACT INTRODUCTION: Laboratory medicine has begun to describe its own future, and the images it produces are almost uniformly expansionary. What they rarely contain is a collapse scenario: a future in which the field delivers less than today. A profession planning for … Read more

Stoichiometric calibration of ceruloplasmin activity with copper enables molar quantification and has implications for the estimation of non-ceruloplasmin-bound copperAlexandra M Kaneon September 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0510. Online ahead of print. ABSTRACT OBJECTIVES: Ceruloplasmin (Cp) and non-ceruloplasmin-bound copper (NCC) are measured when evaluating liver disease and disorders of copper (Cu) metabolism. Cp mass concentration is typically determined by immunoassays that detect both apo- and holoceruloplasmin. In contrast, enzymatic assays measure Cp ferroxidase activity … Read more

The Dutch colon cancer screening programme as an example of adopting indirect-outcome-based analytical performance specifications using a virtual analyser conceptMarith Van Schrojenstein Lantmanon September 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0319. Online ahead of print. ABSTRACT To ensure reported laboratory results are of adequate quality, it is paramount that the set analytical performance specifications (APS) are tailored to the intended uses of the measurand. For measurands with a pivotal position in the clinical pathway, APS should be … Read more

Formula-dependent LDL-C threshold classification and reporting uncertainty in the UK BiobankBohao Xueon September 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0687. Online ahead of print. ABSTRACT OBJECTIVES: Calculated low-density lipoprotein cholesterol (LDL-C) is widely reported, but formula-dependent estimation differences may alter classification near decision thresholds. We assessed formula-dependent LDL-C classification relative to direct LDL-C in UK Biobank and examined cardiovascular outcomes descriptively. METHODS: We analyzed 397,490 participants … Read more

Bacteriuria screening with the new automated platform AutionMax-AutionEye: when to cultureRosanna Falboon September 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0885. Online ahead of print. ABSTRACT OBJECTIVES: Urinary tract infections (UTIs) are very common in clinical practice. Urine culture remains the cornerstone of UTI diagnosis, but urinalysis screening for bacteriuria can improve workflow. The aim of the study was to screen for significant bacteriuria using Aution Eye … Read more

Pre-analytical and analytical validation of calcitonin measurement in fine needle aspiration cytology washoutAmber Materon September 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-1057. Online ahead of print. ABSTRACT OBJECTIVES: Current guidelines advise calcitonin measurements in washout from fine needle aspiration cytology (FNAC) upon inconclusive cytological examination of medullary thyroid cancer (MTC). (Pre-)analytical validation studies of calcitonin measurements in FNAC washout are however missing. In this study, we examined (pre-)analytical … Read more

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