Clinical Chemistry and Laboratory Medicine

Prospective real-time implementation and verification of patient-based real-time quality control using average of normals in a tertiary hospital laboratorySe-Eun Kooon July 16, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 17. doi: 10.1515/cclm-2026-0201. Online ahead of print. ABSTRACT OBJECTIVES: Practical implementation of patient-based real-time quality control (PBRTQC) requires analyte- and institution-specific optimization. This study evaluated the operational feasibility of average-of-normals (AoN)-based PBRTQC through a structured selection process and prospective event-based validation. METHODS: PBRTQC monitoring was performed using the Average … Read more

Establishment of DBS-based reference intervals for vitamins, essential elements, and potentially toxic elements in Chinese adults from Hubei ProvinceMengtong Yangon July 15, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0511. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to establish a comprehensive panel of dried blood spot (DBS)-specific reference intervals (RIs) for vitamins, essential elements, and potentially toxic elements (PTEs) in Chinese adults, and to introduce a hierarchical decision framework for selecting between healthy- and … Read more

Venous-capillary blood agreement for routine chemistry analytes: effects of collection site and sample matrixSara Dezaon July 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 15. doi: 10.1515/cclm-2026-0671. Online ahead of print. ABSTRACT OBJECTIVES: Capillary blood sampling enables minimally invasive testing and decentralized workflows, but interchangeability with venous specimens may depend on collection site, device, and matrix. METHODS: We conducted a single-center, paired clinical study of 480 adults yielding 960 capillary specimens (fingertip lancet … Read more

Flow cytometric analysis of peritoneal dialysis fluid in suspected peritonitis: diagnostic performance and limitationsLea Tybirkon July 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 14. doi: 10.1515/cclm-2026-0684. Online ahead of print. ABSTRACT OBJECTIVES: Peritonitis is a feared complication to peritoneal dialysis (PD), requiring empirical broad-spectrum antibiotics. A rapid method to predict culture positivity and bacterial Gram classification could enable earlier targeted therapy and reduce unnecessary antibiotic exposure. This study evaluated the diagnostic performance … Read more

Performance of the CellaVision advanced RBC application for schistocyte counting in the emergency clinical laboratoryElisa Pivaon July 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 14. doi: 10.1515/cclm-2026-0463. Online ahead of print. ABSTRACT OBJECTIVES: Schistocyte quantification is essential for diagnosing microangiopathic hemolytic anemia (MAHA) and thrombotic microangiopathies (TMA). Early exclusion is critical for guiding appropriate management. However, the reference standard remains time-consuming manual microscopy, highly operator-dependent. In this study, the CellaVision Advanced RBC Application … Read more

Automation of sample preparation workflow for trace elements testing by ICP-MS/MSDifei Sunon July 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 13. doi: 10.1515/cclm-2026-0647. Online ahead of print. ABSTRACT OBJECTIVES: Inductively coupled plasma-mass spectrometry (ICP-MS) is a gold standard for testing trace elements. Despite its wide adoption in clinical laboratories, sample preparation workflows are typically manual and prone to environmental contamination. The objective of this study was to develop an … Read more

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