Clinical Chemistry and Laboratory Medicine

Impact of point of care testing in time to treatment decision-making in emergency departments: a systematic reviewValentina Pecoraroon September 8, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 9. doi: 10.1515/cclm-2026-0604. Online ahead of print. ABSTRACT The main characteristic of point-of-care testing (PoCT) is to provide rapid test results. It remains uncertain whether faster PoCT results truly improve patient management in the emergency department (ED), and how robust the supporting evidence is. This systematic review aimed to … Read more

Vibe coding and the illusion of competence: why laboratory medicine specialists shouldn’t trust their AI-generated code for clinical deploymentSander De Bruyneon September 4, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 7. doi: 10.1515/cclm-2026-0887. Online ahead of print. ABSTRACT The boom of generative artificial intelligence (AI) is empowering laboratory medicine specialists to create clinical software through conversational prompts without formal programming training, a practice referred to as “vibe coding”. Although vibe coding provides unprecedented potential to address workflow inefficiencies, it … Read more

Evaluating feasibility of ferritin assay harmonisation with commutable proof-of-concept reference materials and EQA-based monitoringMoniek M Biochon September 3, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1100. Online ahead of print. ABSTRACT OBJECTIVES: Clinical interpretation of ferritin is hindered by between-assay differences, persisting despite the introduction of different generations of WHO standard. To aid harmonisation efforts, this study investigates the commutability of External Quality Assessment (EQA) materials, proof-of-concept reference materials (cRMs), and the … Read more

Validation of synthetic M-protein materials for external quality assessment: homogeneity, commutability, and stabilityMoniek M Biochon September 3, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-0893. Online ahead of print. ABSTRACT OBJECTIVES: Accurate quantification of M-proteins is important for clinical management of monoclonal gammopathies. Reliable assessment of trueness on M-protein quantification in External Quality Assessment (EQA) schemes is difficult due to the lack of reference methods and materials for target value assignment. … Read more

Translating analytical performance into clinical misclassification risk: a probabilistic framework for HbA1c interpretationLorenza Fagnanion September 2, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1099. Online ahead of print. ABSTRACT OBJECTIVES: Using HbA1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA1c concentrations and components of analytical uncertainty into clinically interpretable … Read more

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