Clinical Chemistry and Laboratory Medicine

Impact of sample size and data origin on the simulation-based analytical performance specification derivationHikmet Can Çubukçuon March 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 20. doi: 10.1515/cclm-2026-0112. Online ahead of print. ABSTRACT OBJECTIVES: Indirect clinical outcome-based analytical performance specifications (APS) may offer a feasible alternative to direct studies but raise questions regarding data requirements and transferability. This study aimed to determine the minimum sample size for simulation-driven APS and to investigate the impact … Read more

Assessing the performance of EWMA and CUSUM algorithms in patient-based real-time quality control of electrolytesÖzlem Doğanon March 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 20. doi: 10.1515/cclm-2026-0049. Online ahead of print. ABSTRACT OBJECTIVES: Patient-based real-time quality control (PBRTQC) represents a useful complement to traditional internal quality control methods, particularly in the continuous monitoring of routine analyses. Sodium, potassium, chloride, calcium, phosphorus, and magnesium are critical for patient safety. This study aimed to evaluate … Read more

Diagnostic accuracy of TIMP-2 and IGFBP7 for detecting acute kidney injury in adult intensive care unit patients: a systematic review and meta-analysisThais F Comizon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0234. Online ahead of print. ABSTRACT Acute kidney injury (AKI) is a frequent complication in hospitalized patients, particularly those admitted to the intensive care unit (ICU), which leads to high rates of morbidity and mortality. Under these conditions, tissue inhibitor metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein … Read more

Unity among the units – a position paper by the DGKLRalf Junkeron March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 18. doi: 10.1515/cclm-2026-0075. Online ahead of print. ABSTRACT More than 30 years after German reunification, the units of measurement used for laboratory medical parameters still differ between eastern and western Germany. While the eastern German states predominantly use “SI” units, “conventional” units are common in medical facilities in the … Read more

S100B urine levels are gestational age, birthweight, delivery mode and gender-dependent in healthy newbornsEbe D’Adamoon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2025-1526. Online ahead of print. ABSTRACT OBJECTIVES: The inclusion of neurobiomarkers (NB) into routine clinical practice remains an unresolved challenge. Among the actions recommended by leading international institutions, a key priority is the establishment of reference curves during the perinatal period. The aim of the study was … Read more

Establishing the laboratory error database: rationale, methodology, and a practical exampleHikmet Can Çubukçuon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0174. Online ahead of print. ABSTRACT Laboratory errors represent a critical yet underestimated threat to patient safety, with 26-30 % of reported errors adversely affecting patient care. Despite extensive scientific literature, no sustainable, open-access platform exists that allows laboratory professionals to rapidly access comprehensive information on error … Read more

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