Clinical Chemistry and Laboratory Medicine

Ultra-trace urinary clostebol findings: should delayed transfer from contaminated objects be considered?Alberto Salomoneon August 27, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 28. doi: 10.1515/cclm-2026-1235. Online ahead of print. ABSTRACT Clostebol is an anabolic androgenic steroid prohibited at all times (class S1.1) by the World Anti-Doping Agency. In several countries, however, clostebol acetate is available without prescription in topical medicinal products, particularly Trofodermin®, creating a substantial risk of inadvertent exposure. Experimental … Read more

From metrological comparability to clinical continuity: authorising laboratory result reporting when changing measurement proceduresRaúl Rigo-Bonninon August 27, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 27. doi: 10.1515/cclm-2026-1271. Online ahead of print. ABSTRACT OBJECTIVES: To develop and apply an operational framework integrating metrological, analytical, clinical and risk evidence to authorise an output-specific reporting rule after a change in measurement procedure. METHODS: Four measurement procedure changes were evaluated: alanine aminotransferase (ALT) procedures with and without … Read more

Diagnostic accuracy of dried blood spot samples for hepatitis B diagnosis: a systematic review and meta-analysisSonghe Wangon August 26, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 26. doi: 10.1515/cclm-2026-1075. Online ahead of print. ABSTRACT INTRODUCTION: Hepatitis B virus (HBV) infection remains a major global public health problem. Dried blood spot (DBS) sampling is simple to collect, stable during transport, and easy to store, and may therefore provide an alternative sampling strategy for decentralized HBV testing. … Read more

A roadmap for standardization of serum albumin measurementsMauro Panteghinion August 22, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1215. Online ahead of print. ABSTRACT Albumin measurements in serum have important diagnostic and prognostic roles. However, non-standardized measurement procedures are still used in medical laboratories. An agreed approach for the implementation of metrological traceability to the International System of Units (SI) of serum albumin measurements is … Read more

Sample volume management: the role of the clinical laboratory in minimizing diagnostic blood lossAna-Maria Šimundićon August 22, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1125. Online ahead of print. ABSTRACT Hospital-acquired anemia is highly prevalent and largely preventable complication of hospitalization, affecting up to 40-74 % of patients and up to 90 % of intensive care units patients. Excessive diagnostic blood loss from routine phlebotomy represents a significant and modifiable contributor, … Read more

Serum neurofilament light chain as a biomarker of inflammatory activity in relapsing-remitting multiple sclerosis: a real-world longitudinal cohort studySilvia de Las Heras Flórezon August 21, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0944. Online ahead of print. ABSTRACT OBJECTIVES: Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudinal monitoring. The reference … Read more

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