Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0936. Online ahead of print. NO ABSTRACT PMID:42453044 | DOI:10.1515/cclm-2026-0936
Clin Chem Lab Med. 2026 Jul 15. doi: 10.1515/cclm-2026-0671. Online ahead of print. ABSTRACT OBJECTIVES: Capillary blood sampling enables minimally invasive testing and decentralized workflows, but interchangeability with venous specimens may depend on collection site, device, and matrix. METHODS: We conducted a single-center, paired clinical study of 480 adults yielding 960 capillary specimens (fingertip lancet … Read more
Clin Chem Lab Med. 2026 Jul 14. doi: 10.1515/cclm-2026-0684. Online ahead of print. ABSTRACT OBJECTIVES: Peritonitis is a feared complication to peritoneal dialysis (PD), requiring empirical broad-spectrum antibiotics. A rapid method to predict culture positivity and bacterial Gram classification could enable earlier targeted therapy and reduce unnecessary antibiotic exposure. This study evaluated the diagnostic performance … Read more
Clin Chem Lab Med. 2026 Jul 14. doi: 10.1515/cclm-2026-0463. Online ahead of print. ABSTRACT OBJECTIVES: Schistocyte quantification is essential for diagnosing microangiopathic hemolytic anemia (MAHA) and thrombotic microangiopathies (TMA). Early exclusion is critical for guiding appropriate management. However, the reference standard remains time-consuming manual microscopy, highly operator-dependent. In this study, the CellaVision Advanced RBC Application … Read more
Clin Chem Lab Med. 2026 Jul 14. doi: 10.1515/cclm-2026-1049. Online ahead of print. NO ABSTRACT PMID:42441760 | DOI:10.1515/cclm-2026-1049
Clin Chem Lab Med. 2026 Jul 13. doi: 10.1515/cclm-2026-0647. Online ahead of print. ABSTRACT OBJECTIVES: Inductively coupled plasma-mass spectrometry (ICP-MS) is a gold standard for testing trace elements. Despite its wide adoption in clinical laboratories, sample preparation workflows are typically manual and prone to environmental contamination. The objective of this study was to develop an … Read more
Clin Chem Lab Med. 2026 Jul 13. doi: 10.1515/cclm-2026-0932. Online ahead of print. NO ABSTRACT PMID:42429132 | DOI:10.1515/cclm-2026-0932
Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0108. Online ahead of print. ABSTRACT OBJECTIVES: Quantitation of plasma vitamins A and E is essential for assessing nutritional status. Traditional methods typically involve liquid-liquid extraction followed by high-performance liquid chromatography with UV detection (HPLC-UV). In this study, we evaluated an automated sample extraction-method paired with liquid … Read more
Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0938. Online ahead of print. ABSTRACT OBJECTIVES: Approximately 30 % of laboratory tests are ordered inappropriately, substantially impacting patient care, costs, and carbon footprint of laboratories. Predefined laboratory test panels are a pragmatic and routinely used tool in laboratories, where tests are bundled for efficiency to diagnose … Read more
Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0643. Online ahead of print. ABSTRACT The 2015 Milan consensus proposed three models for analytical performance (APS) specifications for laboratory tests. Model 1 recommends defining analytical performance specifications based on impact on clinical outcomes. We undertook a targeted literature review to identify and evaluate studies using indirect … Read more
