Clinical Chemistry and Laboratory Medicine

Serum neurofilament light chain as a biomarker of inflammatory activity in relapsing-remitting multiple sclerosis: a real-world longitudinal cohort studySilvia de Las Heras Flórezon August 21, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0944. Online ahead of print. ABSTRACT OBJECTIVES: Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudinal monitoring. The reference … Read more

Diagnostic performance of nanopore sequencing technology for detecting thalassemia and hemoglobinopathyMoe Theingion August 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0783. Online ahead of print. ABSTRACT OBJECTIVES: Thalassemia and hemoglobinopathies are significant genetic disorders in Thailand. Routine diagnostic methods including complete blood count (CBC), hemoglobin (Hb) analysis, and targeted PCR, are effective for detecting common mutations but limited sensitivity for rare and unstable variants, and complex genotypes. … Read more

Interval-specific likelihood ratios improve interpretation of antiphospholipid antibody testing across different analytical platformsJuan Irure-Venturaon August 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0870. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPL) are essential biomarkers for classification, diagnosis, and risk stratification of antiphospholipid syndrome (APS). Although automated analytical platforms, such as chemiluminescent immunoassay (CLIA), and particle-based multi-analyte technology (PMAT), are increasingly implemented in routine laboratories, uncertainty remains regarding their … Read more

How do pre-barcoded tubes improve preanalytical workflow? A survey studySnežana Jovičićon August 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0836. Online ahead of print. ABSTRACT OBJECTIVES: Preanalytical errors account for approximately 60-70 % of all laboratory errors, with sample misidentification among the most frequent causes of inaccurate and unreliable test results. Pre-barcoded tubes (PBTs) are collection tubes uniquely identified during manufacturing with machine-readable labels, eliminating the … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of gentamicin in human serumJo Anne Wrighton August 18, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 19. doi: 10.1515/cclm-2026-0593. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of gentamicin is critical to ensure efficacy and minimize toxicity. We report a candidate reference measurement procedure (RMP) to quantify gentamicin in biological matrices, establishing an unbroken traceability chain to the International System of Units (SI). … Read more

Model 1b analytical performance specifications – report on the Prague 2025 workshopAndrea R Horvathon August 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 18. doi: 10.1515/cclm-2026-1024. Online ahead of print. ABSTRACT The main purpose of establishing APS is to ensure that test performance aligns with their specific clinical goals. Analytical performance specifications serve multiple functions: as acceptance criteria to verify that in vitro diagnostic medical devices (IVD MD) meet regulatory and quality … Read more

Evaluating variability in 24-hour urine free cortisol measurements: impact of sample collection errorsÖmer Özcanon August 16, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0410. Online ahead of print. ABSTRACT OBJECTIVES: 24 hour urine free cortisol measurement is widely used for screening Cushing’s syndrome, but its reliability is limited by variability due to inherent biological variation and variation introduced by collection errors. This study aimed to determine the proportion of inaccurately … Read more

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