Clinical Chemistry and Laboratory Medicine

The Laboratory Medicine Inference Framework: evidentiary boundaries from measurement to clinical actionRaúl Rigo-Bonninon September 2, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-0910. Online ahead of print. ABSTRACT INTRODUCTION: Laboratory medicine relies on multiple metrological, analytical, interpretative, and clinical frameworks. Although each addresses a specific question, the relationships linking measurement, interpretation, clinical translation, and action remain incompletely articulated. This fragmentation may encourage inferential overreach, whereby evidence is used to … Read more

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practiceLuisa Agnelloon September 2, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1113. Online ahead of print. ABSTRACT Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, therapeutic decision-making, and longitudinal disease monitoring. To effectively support clinical decision-making, … Read more

Lipoprotein(a) measurement: challenges and opportunitiesJohn H Contoison September 2, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1262. Online ahead of print. ABSTRACT Lipoprotein(a) [Lp(a)] is a causal, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. New guidelines recommend testing everyone at least once in a lifetime, and with new drugs specifically targeting Lp(a) on the horizon, accurate measurement remains … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of piperacillin in human serum and plasmaSandra Fleischeron September 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0427. Online ahead of print. ABSTRACT OBJECTIVES: Piperacillin is a broad-spectrum antibiotic used to treat critically ill patients with severe infections, requiring therapeutic drug monitoring (TDM). We report the development of an isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure (RMP) to quantify piperacillin in human … Read more

Correlated seasonal dyskalaemia in a primary care population: winter hyperkalaemia and summer hypokalaemiaAmro Maaroufon August 31, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0333. Online ahead of print. ABSTRACT OBJECTIVES: In vitro serum potassium is affected by ambient temperature with peaks in the winter and troughs in the summer. We investigated whether primary care phlebotomy locations with higher winter hyperkalaemia rates exhibited higher summer hypokalaemia and evaluated a simple screening … Read more

A diagnostic strategy for primary aldosteronism diagnosis based on urinary aldosterone assayZhangwei Gaoon August 31, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0865. Online ahead of print. ABSTRACT OBJECTIVES: To compare 24-h urinary excretion of aldosterone (24-h UEA) measured by competitive chemiluminescent immunoassay (cCLIA) and sandwich chemiluminescent immunoassay (sCLIA) with liquid chromatography-tandem mass spectrometry (LC-MS/MS), and to evaluate a direct renin concentration (DRC)-stratified interpretive strategy for primary aldosteronism (PA). … Read more

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