Clinical Chemistry and Laboratory Medicine

The BV calculator: a free, open-source web app for estimation of within-subject and between-subject biological variationHikmet Can Çubukçuon July 24, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0863. Online ahead of print. ABSTRACT OBJECTIVES: Biological variation (BV) data are essential for many purposes in laboratory medicine, however, the complex statistical analysis remains a barrier for delivery of BV data. This study describes the development of a web-based BV Calculator based on the Biological Variation … Read more

Pediatric reference intervals for 27 routine chemistry analytes in healthy children and adolescents on the Roche cobas pro platformBenjamin Jungon July 24, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0627. Online ahead of print. ABSTRACT OBJECTIVES: Accurate interpretation of pediatric laboratory test results requires robust age- and sex-specific reference intervals (RIs). Undertaking studies to establish RIs across the pediatric age range is particularly challenging due to rapid physiological changes during growth and development. While the Roche … Read more

Laboratory medicine 2050: from testing to health intelligence network, a vision from the IFCC Emerging Technologies DivisionDamien Grusonon July 23, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0903. Online ahead of print. ABSTRACT Laboratory medicine is undergoing a profound transformation driven by advances in artificial intelligence (AI), automation, and data interoperability. By 2050, laboratories may evolve from analytical testing facilities into an interconnected health intelligence capable of translating biological, digital, and environmental data into … Read more

Serum hCG reference values in menopausal women across four immunoassay platforms: implications of renal function for clinical interpretationDiane Bavouxon July 22, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0704. Online ahead of print. ABSTRACT OBJECTIVES: Most available data on human chorionic gonadotropin (hCG) elevations in menopausal women are derived from studies using Roche assays, with limited evidence across other immunoassay platforms. This study aimed to establish assay-specific reference values for hCG and evaluate the impact … Read more

Evaluation of the Sysmex UC-1000 test strip reader: fit for purpose in a point-of-care setting?Jana Neirinckon July 22, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0866. Online ahead of print. ABSTRACT OBJECTIVES: Urinalysis is essential for detecting kidney disease, urinary tract infections, and diabetes mellitus. Point-of-care testing enables rapid screening in decentralized settings and supports low-throughput laboratories. This study evaluated the Sysmex UC-1000 according to the 2023 EFLM urinalysis guidelines in a … Read more

Choosing Wisely – avoiding medical overuse: evidence assessment of recommendations on laboratory parametersCihan Berion July 21, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0358. Online ahead of print. ABSTRACT OBJECTIVES: Launched in 2012, the Choosing Wisely initiative promotes evidence-based recommendations to reduce unnecessary tests and treatments. This study reviewed laboratory-related recommendations from five countries (USA, UK, Germany, Switzerland, and Austria) to assess their scientific validity. METHODS: Choosing Wisely websites were … Read more

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