Clinical Chemistry and Laboratory Medicine

Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1215. Online ahead of print. ABSTRACT Albumin measurements in serum have important diagnostic and prognostic roles. However, non-standardized measurement procedures are still used in medical laboratories. An agreed approach for the implementation of metrological traceability to the International System of Units (SI) of serum albumin measurements is … Read more

Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1335. Online ahead of print. NO ABSTRACT PMID:42631445 | DOI:10.1515/cclm-2026-1335

Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1125. Online ahead of print. ABSTRACT Hospital-acquired anemia is highly prevalent and largely preventable complication of hospitalization, affecting up to 40-74 % of patients and up to 90 % of intensive care units patients. Excessive diagnostic blood loss from routine phlebotomy represents a significant and modifiable contributor, … Read more

Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0944. Online ahead of print. ABSTRACT OBJECTIVES: Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudinal monitoring. The reference … Read more

Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0783. Online ahead of print. ABSTRACT OBJECTIVES: Thalassemia and hemoglobinopathies are significant genetic disorders in Thailand. Routine diagnostic methods including complete blood count (CBC), hemoglobin (Hb) analysis, and targeted PCR, are effective for detecting common mutations but limited sensitivity for rare and unstable variants, and complex genotypes. … Read more

Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0870. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPL) are essential biomarkers for classification, diagnosis, and risk stratification of antiphospholipid syndrome (APS). Although automated analytical platforms, such as chemiluminescent immunoassay (CLIA), and particle-based multi-analyte technology (PMAT), are increasingly implemented in routine laboratories, uncertainty remains regarding their … Read more

Clin Chem Lab Med. 2026 Aug 20. doi: 10.1515/cclm-2026-0877. Online ahead of print. NO ABSTRACT PMID:42618552 | DOI:10.1515/cclm-2026-0877

Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0836. Online ahead of print. ABSTRACT OBJECTIVES: Preanalytical errors account for approximately 60-70 % of all laboratory errors, with sample misidentification among the most frequent causes of inaccurate and unreliable test results. Pre-barcoded tubes (PBTs) are collection tubes uniquely identified during manufacturing with machine-readable labels, eliminating the … Read more

Clin Chem Lab Med. 2026 Aug 19. doi: 10.1515/cclm-2026-0593. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of gentamicin is critical to ensure efficacy and minimize toxicity. We report a candidate reference measurement procedure (RMP) to quantify gentamicin in biological matrices, establishing an unbroken traceability chain to the International System of Units (SI). … Read more

Clin Chem Lab Med. 2026 Aug 14. doi: 10.1515/cclm-2026-1231. Online ahead of print. NO ABSTRACT PMID:42609098 | DOI:10.1515/cclm-2026-1231