Clinical Chemistry and Laboratory Medicine

Delivering the EU Safe Hearts Plan: the essential role of laboratory medicine in cardiovascular healthDamien Grusonon September 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1439. Online ahead of print. ABSTRACT The European Union Safe Hearts Plan provides an opportunity to strengthen cardiovascular prevention, early detection, treatment, and monitoring across Europe. This EFLM position paper argues that laboratory medicine must be recognized as a central component of its implementation. Reliable and harmonized … Read more

Filling the gaps in high-priority reference materials for implementing metrological traceability in laboratory medicineMauro Panteghinion September 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1332. Online ahead of print. ABSTRACT The global harmonization of measurements in laboratory medicine is facilitated by the development and implementation of reference measurement systems, including suitable certified reference materials (CRMs). There are, however, a relatively small number of CRM producers worldwide. In the context of limited … Read more

Availability and characteristics of external quality assessment (EQA) schemes for measurement of hemolysis, icterus and lipemia (HIL) in routine coagulation testing, a collaborative study from the European Organisation for External Quality Assurance in Laboratory Medicine (EQALM)Ann Helen Kristoffersenon September 18, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1130. Online ahead of print. NO ABSTRACT PMID:42758902 | DOI:10.1515/cclm-2026-1130

Digital and computational morphology in hematology: current platforms, clinical evidence, and future requirementsGina Zinion September 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1265. Online ahead of print. ABSTRACT INTRODUCTION: Morphologic examination of peripheral blood and bone marrow remains central to the diagnosis and classification of hematologic disorders. Conventional optical microscopy, however, is labor-intensive, dependent on operator expertise, and affected by interobserver variability. Digital morphology has developed from automated image … Read more

Alternative futures for laboratory medicine in 2050: scenarios and signposts for diagnostic capability contractionKoichiro Yujion September 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1377. Online ahead of print. ABSTRACT INTRODUCTION: Laboratory medicine has begun to describe its own future, and the images it produces are almost uniformly expansionary. What they rarely contain is a collapse scenario: a future in which the field delivers less than today. A profession planning for … Read more

Stoichiometric calibration of ceruloplasmin activity with copper enables molar quantification and has implications for the estimation of non-ceruloplasmin-bound copperAlexandra M Kaneon September 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0510. Online ahead of print. ABSTRACT OBJECTIVES: Ceruloplasmin (Cp) and non-ceruloplasmin-bound copper (NCC) are measured when evaluating liver disease and disorders of copper (Cu) metabolism. Cp mass concentration is typically determined by immunoassays that detect both apo- and holoceruloplasmin. In contrast, enzymatic assays measure Cp ferroxidase activity … Read more

The Dutch colon cancer screening programme as an example of adopting indirect-outcome-based analytical performance specifications using a virtual analyser conceptMarith Van Schrojenstein Lantmanon September 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0319. Online ahead of print. ABSTRACT To ensure reported laboratory results are of adequate quality, it is paramount that the set analytical performance specifications (APS) are tailored to the intended uses of the measurand. For measurands with a pivotal position in the clinical pathway, APS should be … Read more

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